Low vitamin D levels are associated with high viral loads in patients with chronic hepatitis B: a systematic review and meta-analysis
vYe-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao Xun Email author
Items in both categories Liver and Virus are listed here:
- Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
- Chronic Hepatitis D viral infection 3.6 X more likely if low vitamin D – July 2021
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Hepatitis B virus and Vitamin D - many studies
- Hepatitis B virus might be treated by Vitamin D – April 2015
- Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014
- Hepatitis B clinical event was 2X more likely if low vitamin D – Oct 2014
- Vitamin D prevents Hepatitis-C and helps treat it (many studies)
- Hepatitis C drug is extremely expensive, why not try Calcidiol (semi-processed vitamin D) - May 2014
- Vitamin D Deficiency May Help Spread of Hepatitis B Throughout Liver – May 2013
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Background
Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present meta-analysis was carried out to compare the vitamin D levels between patients with chronic hepatitis B (CHB) and healthy controls, and to determine whether vitamin D levels were correlated with HBV viral loads significantly.
Methods
A systematic search was conducted via PubMed, Web of Science, EMBASE and the Cochrane Library to identify eligible studies until September 28, 2017. We calculated pooled mean difference (MD) and 95% confidence intervals (CI) to quantitatively estimate the difference of vitamin D levels between CHB patients and controls. In addition, correlation between serum vitamin D levels and HBV viral loads was defined by summary correlation coefficient (r value) and the corresponding 95% CI.
Results
A total of 7 studies involving 814 CHB patients and 696 healthy controls were included. A significantly decreased vitamin D levels was found in CHB patients compared with healthy controls: pooled MD (95% CI) was − 2.03 ng/mL (− 2.60, − 1.46). Latitude-stratified subgroup analysis indicated this difference was more obvious in low latitude areas, with a bigger pooled MD (95% CI) of − 2.72 ng/mL (− 4.57, − 0.87). In addition, we observed an inverse correlation between serum vitamin D levels and HBV viral loads: pooled r (95% CI) was − 0.41(− 0.54, − 0.27).
Conclusions
Our results showed that vitamin D levels were lower in CHB patients than that of healthy controls and inversely correlated with HBV viral loads, although future comprehensive studies are needed to clarify the underlying mechanisms.