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High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022

Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis

AMA Netw Open. 2022 Apr 1;5(4):e227410 doi: 10.1001/jamanetworkopen.2022.7410.
Nicklas Brustad 1, Sina Yousef 1, Jakob Stokholm 1 2, Klaus Bønnelykke 1, Hans Bisgaard 1, Bo Lund Chawes 1

High- Dose Daily (<10,000 IU)

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Bolus dose (<600,000 IU) note: Bolus taken over 1 - 60 days = Loading

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Importance: Several health benefits of vitamin D have been suggested; however, the safety of high-dose supplementation in early childhood is not well described.

Objective: To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.

Data sources: PubMed and ClinicalTrials.gov were searched through August 24, 2021.
Study selection: Randomized clinical trials of high-dose vitamin D supplementation in children aged 0 to 6 years, defined as greater than 1000 IU/d for infants (aged 0-1 year) and greater than 2000 IU/d for children aged 1 to 6 years.

Data extraction and synthesis: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, 2 reviewers independently extracted the data from the eligible studies. Summary risk ratio (RR), 95% CI, and P values were derived from random-effects meta-analysis.
Main outcomes and measures: Adverse events, serious adverse events (SAEs), and/or levels of 25-hydroxyvitamin D, calcium, alkaline phosphatase, phosphate, parathyroid hormone, and/or the ratio of urine calcium to creatinine levels.

Results: A total of 32 randomized clinical trials with 8400 unique participants were included. Different clinical outcomes of children receiving high-dose vitamin D supplements ranging from 1200 to 10 000 IU/d and bolus doses from 30 000 IU/week to a single dose of 600 000 IU were evaluated. Eight studies with 4612 participants were eligible for meta-analysis using a control group receiving either low-dose vitamin D supplementation (≤400 IU/d) or placebo when investigating the risk of SAEs such as hospitalization or death.
No overall increased risk of SAEs in the high-dose vitamin D vs control groups was found (RR, 1.01 [95% CI, 0.73-1.39]; P = .89, I2 = 0%).
In addition, risk of hypercalcemia (n = 726) was not increased (RR, 1.18 [95% CI, 0.72-1.93]; P = .51).
Clinical adverse events potentially related to the vitamin D supplementation reported in the studies were rare.

Conclusions and relevance: This meta-analysis and systematic review found that high-dose vitamin D supplementation was not associated with an increased risk of SAEs in children aged 0 to 6 years, and that clinical adverse events potentially related to the supplementation were rare. These findings suggest that vitamin D supplementation in the dose ranges of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to young children may be well tolerated.

Summary clipped from PDF

"Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases."
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VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022 - all ages)

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Items found: 489
Title Modified
Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis Feb 2023 23 Feb, 2023
High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023 28 Jan, 2023
Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023 25 Jan, 2023
High-Dose 18 Jan, 2023
Some pathogens and health problems restrict Vitamin D from being used – Coimbra high-dose protocol – April 2021 18 Jan, 2023
Muscular Dystrophy treated by high-dose Vitamin D - many studies 18 Jan, 2023
Diseases treated by high-dose Vitamin D - many studies 18 Jan, 2023
50,000 IU and other high dose vitamin studies 15 Jan, 2023
Coimbra protocol using high-dose Vitamin D is safe – April 2022 22 Dec, 2022
Happiest country on earth has a high Vitamin D level (Finland, with little sun) – March 2022 27 Nov, 2022
Surgeries more successful if high vitamin D (tympanic membrane in this case) – Nov 2022 11 Nov, 2022
Better Surgical outcomes if preceded by Vitamin D loading dose – Oct 2018 19 Oct, 2022
Surgeries to re-establish blood in brain, heart, etc. are far more successful with high Vitamin D levels – March 2022 08 Oct, 2022
High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022 06 Oct, 2022
Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022 14 Sep, 2022
CDC says 44 percent of people hospitalized with COVID had third dose or booster - Sept 2022 10 Sep, 2022
Ignoring dose size etc, meta-analysis concludes that Vitamin D does not help (stroke risk in this case) – Aug 2022 05 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
Test Vitamin D, get a tiny dose, no benefit, conclusion: should not have tested (Australia this time) – Aug 2022 26 Aug, 2022
4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022 17 Jul, 2022
Multiple Sclerosis treated by Vitamin D (includes dose-response) - July 2022 11 Jul, 2022
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 09 Jul, 2022
Alzheimer’s delayed 4.7 years by high Omega-3 index (7.6 years if also have APOE-4) June - 2022 17 Jun, 2022
Treat COVID with early high-dose Vitamin D (20th as of June 2022) 16 Jun, 2022
Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021 09 Jun, 2022
Loading Dose of Vitamin D 22 May, 2022
Loading dose of Vitamin D for patients hospitalized with COVID (140,000 IU) – RCT completed 2021 22 May, 2022
High-Dose Vitamin D puts surplus calories into muscles instead of fat (mice) – May 2022 20 May, 2022
High levels of Selenium while pregnant associated with 21 percent more Vitamin D - April 2022 14 May, 2022
Is 50 ng of vitamin D too high, just right, or not enough 14 May, 2022
Moderate to high Myopia 2X more likely if low Vitamin D (China) – June 2021 10 May, 2022
Comparing High-dose vitamin D therapies 04 May, 2022
COVID death 6.9X less likely if high Magnesium to Calcium ratio – April 2022 20 Apr, 2022
High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022 15 Apr, 2022
High-altitude associated with higher vitamin D and better bones (sheep in this case) – Feb 2013 12 Apr, 2022
More surviving offspring if mother had high vitamin D (sheep in this case) – Jan 2016 12 Apr, 2022
High altitudes reduce the COVID-19 infection (not a surprise) – April 2022 11 Apr, 2022
Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022 28 Mar, 2022
Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022 25 Feb, 2022
Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 23 Feb, 2022
Beyond vitamin D - book of testimonials on high-dose Coimbra Protocol - Aug, 2021 16 Feb, 2022
High-Dose Vitamin D Therapy – book July 2018 11 Feb, 2022
High Vitamin D associated with 3.4 X less risk of possibly Cancerous Thyroid Nodules - Feb 2022 09 Feb, 2022
4,000 IU of Vitamin D is too small a dose to help Obese - RCT Feb 2022 09 Feb, 2022
High-dose Vitamin D is safe and effective – review of 10 studies – Sept 2021 08 Feb, 2022
Alzheimer's 3X higher risk in countries with high meat consumption - 2016 01 Feb, 2022
HIV treatment augmented by high-dose vitamin D, daily or weekly – Dec 2021 30 Jan, 2022
Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022 25 Jan, 2022
2,500 IU Vitamin D is the max dose size in Canada 15 Jan, 2022
COVID test positive 2X less likely if high vitamin D, Calcifediol looking good, etc. – Dec 31, 2021 01 Jan, 2022
3X more pregnancies when Vitamin D levels are high (assisted reproduction, women only) – Oct 2021 17 Dec, 2021
Omicron may require fourth vaccine dose, Pfizer says - Dec 10, 2021 17 Dec, 2021
Off Topic: Exercycle for high-intensity exercise with UV 11 Dec, 2021
Large dose of calcifediol or vitamin D up to 15 days before COVID hospitalization reduced death rates (1.5X, 1.3X) – Dec 2021 04 Dec, 2021
Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021 28 Nov, 2021
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
2700 IU of vitamin D needed to get above 20 ng if dark-skinned and high latitude – Oct 2021 27 Oct, 2021
Childhood cancers – give Vitamin D loading dose if low – Oct 2021 27 Oct, 2021
Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated 18 Oct, 2021
Wattage produced by Elite indoor athletes: 3.9 W per kg if high Vitamin D vs 3.5 if low – Oct 2021 15 Oct, 2021
High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021 14 Oct, 2021
Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021 14 Oct, 2021
Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021 07 Oct, 2021
Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016 05 Oct, 2021
Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020 30 Sep, 2021
COVID-19 deaths - 30 percent fewer if high UVA (US, etc) – Aug 2021 30 Sep, 2021
4th highest county in the US has a very low COVID-19 rate (high UV, high vitamin D) 29 Sep, 2021
Vitamin D3 better than D2, especially if non-daily or high dose - meta-analysis Sept 2021 23 Sep, 2021
Lung cancer 24 percent less likely if high vitamin D (never-smoking senior women) – Sept 2017 09 Sep, 2021
One group of coal miners had surprising high Vitamin D levels in Sept (suspect low-cost UVB) – Sept 2021 08 Sep, 2021
Vitamin D and COVID, review of evidence, loading dose if less than 50 ng - Masterjohn Sept 2021 05 Sep, 2021
High-dose vitamin D improves health (presentation) - Aug 30, 2021 30 Aug, 2021
High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021 28 Aug, 2021
Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021 25 Aug, 2021
Metabolic Syndrome again fought by Vitamin D (fails to say dose sizes) – Review Aug 2021 25 Aug, 2021
Ultra-Orthodox Jews have concealing clothing, high levels of COVID-19, and ultra low Vitamin D - Feb 2021 07 Aug, 2021
Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021 19 Jul, 2021
Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 08 Jul, 2021
High dose vitamin D for Autoimmune diseases - Portuguese - 2019 01 Jul, 2021
Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021 29 Jun, 2021
High Dose Vitamin D for autoimmune diseases -blog June 13, 2021 20 Jun, 2021
COVID-19 death in hospital 5X more likely if low vs high vitamin D – preprint June 2021 17 Jun, 2021
Vitamin D trials: constant dose vs. minimum concentration, number of participants needed – May 2021 25 May, 2021
High Vitamin B12 levels associated with 1.7 X increased risk of death – Jan 2020 22 May, 2021
Bone healing not improved by a single bolus dose of 30,000 IU (no surprise) – RCT April 2021 28 Apr, 2021
Bone loss results in blood vessel plaque if low Vitamin K2, less bone loss if high K2– April 2021 26 Apr, 2021
High PTH plus low Vitamin D is not good (5X more likely for COPD to need hospital) – April 2021 25 Apr, 2021
Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021 17 Apr, 2021
Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021 13 Apr, 2021
Autoimmune and high-dose vitamin D (Dr. Coimbra) - Dr. Mahtani video and transcript - Nov 2020 11 Apr, 2021

VitaminDWiki - Loading Doses for Infants-Children are effective and safe (23 studies)

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VitaminDWiki - Toxicity and Infants-Children (7 studies)

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Created by admin. Last Modification: Wednesday January 18, 2023 18:03:22 GMT-0000 by admin. (Version 13)
High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022        
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