Table of contents
- Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis
- VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022 - all ages)
- VitaminDWiki - Loading Doses for Infants-Children are effective and safe (
23 studies) - VitaminDWiki - Toxicity and Infants-Children (
7 studies)
Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis
AMA Netw Open. 2022 Apr 1;5(4):e227410 doi: 10.1001/jamanetworkopen.2022.7410.
Nicklas Brustad 1, Sina Yousef 1, Jakob Stokholm 1 2, Klaus Bønnelykke 1, Hans Bisgaard 1, Bo Lund Chawes 1High- Dose Daily (<10,000 IU)
Bolus dose (<600,000 IU) note: Bolus taken over 1 - 60 days = Loading
Importance: Several health benefits of vitamin D have been suggested; however, the safety of high-dose supplementation in early childhood is not well described.Objective: To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.
Data sources: PubMed and ClinicalTrials.gov were searched through August 24, 2021.
Study selection: Randomized clinical trials of high-dose vitamin D supplementation in children aged 0 to 6 years, defined as greater than 1000 IU/d for infants (aged 0-1 year) and greater than 2000 IU/d for children aged 1 to 6 years.Data extraction and synthesis: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, 2 reviewers independently extracted the data from the eligible studies. Summary risk ratio (RR), 95% CI, and P values were derived from random-effects meta-analysis.
Main outcomes and measures: Adverse events, serious adverse events (SAEs), and/or levels of 25-hydroxyvitamin D, calcium, alkaline phosphatase, phosphate, parathyroid hormone, and/or the ratio of urine calcium to creatinine levels.Results: A total of 32 randomized clinical trials with 8400 unique participants were included. Different clinical outcomes of children receiving high-dose vitamin D supplements ranging from 1200 to 10 000 IU/d and bolus doses from 30 000 IU/week to a single dose of 600 000 IU were evaluated. Eight studies with 4612 participants were eligible for meta-analysis using a control group receiving either low-dose vitamin D supplementation (≤400 IU/d) or placebo when investigating the risk of SAEs such as hospitalization or death.
No overall increased risk of SAEs in the high-dose vitamin D vs control groups was found (RR, 1.01 [95% CI, 0.73-1.39]; P = .89, I2 = 0%).
In addition, risk of hypercalcemia (n = 726) was not increased (RR, 1.18 [95% CI, 0.72-1.93]; P = .51).
Clinical adverse events potentially related to the vitamin D supplementation reported in the studies were rare.Conclusions and relevance: This meta-analysis and systematic review found that high-dose vitamin D supplementation was not associated with an increased risk of SAEs in children aged 0 to 6 years, and that clinical adverse events potentially related to the supplementation were rare. These findings suggest that vitamin D supplementation in the dose ranges of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to young children may be well tolerated.
Summary clipped from PDF
"Thus, our findings suggest that vitamin D supplementation in the high-dose range of 1200 to 10 000 IU/d and bolus doses to 600 000 IU to infants and preschool children to 6 years of age may be safe in both healthy children and in children with various diseases."
 Download the PDF from VitaminDWiki
VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022 - all ages)
This list is automatically updated
Items found: 489
VitaminDWiki - Loading Doses for Infants-Children are effective and safe (
23 studies) This list is automatically updated
- Growing pains reduced in 91% of children with a single dose of Vitamin D – July 2024
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- Child soccer players who were deficient were helped by a single 200,000 IU vitamin D dose – RCT May 2020
- Infant Vitamin D doubles 6 months after birth (can double in 2 weeks)– Oct 2019
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- 2X improved development by severely malnourished children with 2 loading doses of vitamin D – RCT May 2018
- 100,000 IU Vitamin D weekly for 4 weeks is safe and effective for children – May 2019
- Vitamin D loading dose of 300,000 IU for children – 3 weeks with capsules, biscuits, injection – RCT Aug 2018
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Quick restoration of vitamin D in children – 10,000 IU per kg loading dose was not enough – Jan 2017
- Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Pediatric trials of high dose vitamin D -163 are in a single online database – Feb 2016
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 600,000 IU of vitamin D2 every 4 months for decades in East Germany – 1987
VitaminDWiki - Toxicity and Infants-Children (
7 studies) This list is automatically updated
- Vitamin D Toxicity with no long term problems starts at 300 ng (infant with 222 ng had no symptoms) – March 2022
- Vitamin D toxicity is extremely rare, accidental, and very mild in Iranian children – July 2020
- Infant hospitalized after Vitamin D overdose (8,000 X too much) Feb 2016
- Rare infant vitamin D toxicity – due to errors which resulted in more that 240,000 IU – Jan 2014
- Concern about accidentally giving infant too much liquid vitamin D – Aug 2012
- Dosing error gave 12000 IU daily vitamin D to infant, but no indication of any problem – April 2012
- CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011
High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 20222815 visitors, last modified 18 Jan, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 17418 bolus Safe.jpg admin 15 Apr, 2022 27.26 Kb 1379 17417 hidh Dose safe.jpg admin 15 Apr, 2022 37.29 Kb 1688 17416 Safety of High-Dose_CompressPdf.pdf admin 15 Apr, 2022 135.48 Kb 270 - VitaminDWiki - Toxicity and Infants-Children (