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Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014

Comparison of two regimens of vitamin D supplementation for vitamin D-deficient neonates.

Singapore Med J. 2014 May;55(5):266-70.
Shakiba M1, Pahloosye A, Mirouliaei M, Islami Z.

Vitamin D deficiency is common in pregnant women, and supplementation of vitamin D is necessary for the infants of these women. This study explored the efficacy of an alternative way of vitamin D supplementation in an area with a high prevalence of vitamin D deficiency in mothers.
This was a non-randomised clinical trial conducted in 2010 in Yazd, Iran. Full-term healthy infants born to vitamin D-deficient mothers (n = 82) were divided into the high-dose regimen (HDR; single oral bolus 30,000 IU vitamin D3, n = 34) and the standard-dose regimen (SDR; 400 IU/day vitamin D3 within two weeks of life, n = 48) groups. 25-hydroxyvitamin D (25OHD) was measured using chemiluminescent immunoassays, and 25OHD level > 20 ng/mL was deemed sufficient.
Over 90% of infants in the HDR group attained vitamin D sufficiency within one month, while comparable sufficiency was reached in the SDR group only after four months. At two months, the proportion of infants attaining 25OHD > 30 ng/mL was 93.3% and 27.9% in the HDR and SDR groups, respectively (p = 0.003). None of our infants achieved 25OHD levels > 100 ng/mL.
For infants born to vitamin D-deficient mothers, oral supplementation of 30,000 IU vitamin D3 during the first month of life, followed by a routine recommended dose of 400 IU/day, should be considered. The four-month lag for attaining vitamin D sufficiency in 90% of infants in the SDR group may have clinical implications and should be further investigated.

PMID: 24862751

Virtually all infants with loading dose got > 30 ng


Loading dose group had much higher Vitamin D levels at 2 months


Note by VitaminDWiki: Mothers in Iran have very low levels of vitamin D. This large of a loading dose may not be needed elsewhere

See also VitaminDWiki

items in BOTH of categories: infants and loading dose

Attached files

ID Name Comment Uploaded Size Downloads
3969 Levels with loading.jpg admin 28 May, 2014 27.94 Kb 1422
3968 Loading neonate.jpg admin 28 May, 2014 22.93 Kb 1553
3967 Loading dose neonate.pdf admin 28 May, 2014 673.97 Kb 1147