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High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023


Vitamin D deficiency in patients with diabetes and its correlation with water fluoride levels

J Water Health . 2023 Jan;21(1):125-137. doi: 10.2166/wh.2022.254.
Pramod Kumar 1, Rasna Gupta 2, Ankit Gupta 3

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Chronic exposure to fluoride through drinking water has been linked to insulin resistance and resulting type 2 diabetes mellitus (T2DM). Here, we aim to study the impact of water fluoride levels on blood glucose and vitamin D levels. A hospital-based study was conducted on diabetic patients (n = 303) at All India Institute of Medical Sciences (AIIMS), Raebareli outstation patient department (OPD). The relationship between vitamin D or fasting blood glucose levels (BGLs) with water fluoride levels was estimated through Spearman's rank correlation. We found a significant negative correlation between water fluoride and vitamin D levels [rs = -0.777, p-value < 0.001] and a positive correlation between water fluoride and fasting BGLs [rs = 0.178, p-value <0.05].
The participants residing in fluoride-endemic areas (F > 1.5 mg/L) had higher odds of severe vitamin D deficiency (odds ratio: 5.07, 95% CI: 1.9-13.2, p-value = 0.0009). The results demonstrate that vitamin D deficiency and fasting BGLs are significantly associated with water fluoride levels. This study signifies the role of fluoride toxicity in poor glycemic control and derived vitamin D deficiency. Vitamin D supplementation and the application of standard household water purification devices are recommended to tackle vitamin D deficiency in fluoride-endemic areas.
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High Fluoride concentations in ground water in areas with Vitamin D deficiency

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Examples: Mongolia, Middle East


Fluoride in Volcanic Areas: A Case Study in Medical Geology- May 2019

DOI: 10.5772/intechopen.86058
Diana Paula Silva Linhares, Patrícia Ventura Garcia and Armindo dos Santos Rodrigues

Volcanic regions have always attracted many people worldwide because of the high fertility of their soils. However, human proximity to volcanoes can lead to several health problems as consequence of the chronic exposure to the materials released from the volcanic activity. An element often found in elevated concentrations in volcanic regions is fluorine. Although fluoride is recognized to have a beneficial effect on the rate of occurrence of dental caries when ingested in small amounts, its excessive intake results in a widespread but preventable pathological disease called fluorosis. While skeletal fluorosis, the most severe form of fluorosis, requires a chronic exposure to high concentrations of fluoride in water (4–8 mg/L), dental fluorosis occurs after shorter periods of exposure to fluoride in lower concentrations (1.5–2.0 mg/L). In some volcanic regions, where exposure to elevated amounts of fluoride is persistent, biomonitoring programs are fundamental to assess the main sources of exposure and to evaluate the effects of the exposure in resident populations. This chapter aims to cover the main effects of fluoride exposure in humans and discuss the use of a multidisciplinary approach that brings together the geoscience, biomedical, and public health communities to address environmental health problems.
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Global analysis and prediction of fluoride in groundwater - 2022

NATURE COMMUNICATIONS | (2022)13:4232 |https://doi.org/10.1038/s41467-022-31940-x|
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The health of millions of people worldwide is negatively impacted by chronic exposure to elevated concentrations of geogenic fluoride in groundwater. Due to health effects including dental mottling and skeletal fluorosis, the World Health Organization maintains a maximum guideline of 1.5mg/L in drinking water. As groundwater quality is not regularly tested in many areas, it is often unknown if the water in a given well or spring contains harmful levels of fluoride. Here we present a state-of-the-art global fluoride hazard map based on machine learning and over 400,000 fluoride measurements (10% of which >1.5 mg/L), which is then used to estimate the human population at risk. Hotspots indicated by the groundwater fluoride hazard map include parts of central Australia, western North America, eastern Brazil and many areas of Africa and Asia. Of the approximately 180 million people potentially affected worldwide, most reside in Asia (51-59% of total) and Africa (37-46% of total), with the latter representing 6.5% of the continent's population. Africa also contains 14 of the top 20 affected countries in terms of population at risk. We also illuminate and discuss the key globally relevant hydrochemical and environmental factors related to fluoride accumulation.
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Fluoride in natural waters - 2013

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Excess fluoridation reduces Magnesium, and causes health problems


11+ VitaminDWiki pages with FLUORIDE in the title

This list is automatically updated

Items found: 12

VitaminDWiki – Interactions with Vitamin D contains

Interactions with Vitamin D has 117 items

Various drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Plastics, BPA, PCB and Vitamin D deficiency
Smoking   Coffee
Cooked dried beans or peas

Attached files

ID Name Comment Uploaded Size Downloads
19159 natural Fluoride.jpg admin 28 Jan, 2023 118.09 Kb 135
19158 Floride higher than 1.5.jpg admin 28 Jan, 2023 42.07 Kb 127
19157 world map fluoride.jpg admin 28 Jan, 2023 171.49 Kb 141
19156 Fluoride in natural waters - including Iceland_CompressPdf.pdf admin 28 Jan, 2023 1.37 Mb 89
19155 Global analysis and prediction of fluoride in groundwater_CompressPdf.pdf admin 28 Jan, 2023 720.34 Kb 80
19154 Medical Geology.pdf admin 28 Jan, 2023 249.26 Kb 79
19151 fluoride-map-395_tcm18-118679.jpg admin 28 Jan, 2023 24.20 Kb 144
19150 Fluoride vs D.jpg admin 28 Jan, 2023 51.88 Kb 223
19149 diabetes D Fl.pdf admin 28 Jan, 2023 507.08 Kb 83