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Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021


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MetS in children decreased 12% per each 10 ng of Vitamin D – meta-analysis July 2021

Metabolic syndrome risk in children decreased 12 percent for each 10 ng increase in Vitamin D – meta-analysis July 2021

MetS 3X less likely if 60 ng of vitamin D – meta-analysis June 2021

Serum vitamin D status and metabolic syndrome: a systematic review and dose-response meta-analysis
Nutr Res Pract. 2021 Jun;15(3):329-345. doi: 10.4162/nrp.2021.15.3.329
Kyueun Lee 1, Jihye Kim 1
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Background/objectives: Evidence has suggested an association between serum vitamin D and metabolic syndrome (MetS), but prospective studies are very limited. The objective was to assess the dose-response association between serum vitamin D concentration and MetS risk using a systematic review and meta-analysis of updated observational studies.

Materials/methods: Using MEDLINE, PubMed, and Embase, a systematic literature search was conducted through February 2020 and the references of relevant articles were reviewed. A random-effects model was used to estimate the summary odds ratio/relative risk and 95% confidence interval (CI). Heterogeneity among studies was evaluated with I2 statistic. In total, 23 observational studies (19 cross-sectional studies, and four cohort studies) were included in the meta-analysis.

Results: The pooled estimates (95% CI) for MetS per 25-nmol/L increment in serum vitamin D concentration were 0.80 (95% CI, 0.76-0.84; I2 = 53.5) in cross-sectional studies, and 0.85 (95% CI, 0.72-0.98; I2 = 85.8) in cohort studies. Similar results were observed, irrespectively of age of study population, study location, MetS criteria, and adjustment factors. There was no publication bias for the dose-response meta-analysis of serum vitamin D concentrations and MetS.

Conclusions: Dose-response meta-analysis demonstrated that a 25-nmol/L increment in the serum vitamin D concentration was associated with 20% and 15% lower risks of MetS in cross-sectional studies and cohort studies, respectively.

MetS 1.4 X less likely if OK vitamin D – meta-analysis April 2021

Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose-response meta-analysis of epidemiologic studies
Obes Rev. 2021 Apr 7;e13223. doi: 10.1111/obr.13223
Zahra Hajhashemy 1, Farnaz Shahdadian 1, Elham Moslemi 2, Fateme Sadat Mirenayat 1, Parvane Saneei 1

Several epidemiological studies examined the association of serum vitamin D with metabolic syndrome (MetS), but the findings were inconsistent. We conducted a systematic review and dose-response meta-analysis to quantify the association between blood vitamin D levels and MetS in adults. A systematic search up to December 2020 was conducted in MEDLINE (PubMed), ISI (Web of Science), Scopus, and Google Scholar databases for epidemiological studies that assessed the relation of serum 25-hydroxyvitamin D (as the exposure) and MetS (as the outcome) in adults. Eligible cross-sectional studies were restricted to those with representative populations. Finally, 43 studies were included in the analysis (38 cross-sectional, one nested case-control, and four cohorts studies).
Combining 41 effect sizes from 38 cross-sectional studies included 298,187 general adult population revealed that the highest level of serum vitamin D, compared with the lowest level, was significantly related to a 43% decreased odds of MetS in developed countries (odds ratio [OR]: 0.57; 95% confidence interval [CI]: 0.49-0.65) and 40% in developing countries (OR: 0.60; 95% CI: 0.52-0.70).
Linear dose-response analysis (including 222,175 healthy individuals and 39,308 MetS patients) revealed that each 25 nmol/L increase in serum vitamin D level was significantly associated with a 15% decreased odds of MetS (OR: 0.85; 95% CI: 0.80-0.91); however, we found no significant nonlinear association. Meta-analysis of five prospective studies with 11,019 participants revealed no significant relation (relative risk [RR]: 0.70; 95% CI: 0.37-1.32). This meta-analysis indicated an inverse association between serum vitamin D concentrations and risk of MetS in general adult populations in cross-sectional studies in a dose-response manner. However, no significant association was found in a small number of cohorts. More prospective studies are needed to confirm the causality of this relationship.
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References April 2021
  1. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28(4):629-636. https://doi.org/10.1161/atvbaha.107.151092
  2. Schnack LL, Romani AMP. The metabolic syndrome and the relevance of nutrients for its onset. Recent Pat Biotechnol. 2017;11(2):101-119. https://doi.org/10.2174/1872208311666170227112013
  3. Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-237. https://doi.org/10.1242/dmm.001180
  4. Cornier MA, Dabelea D, Hernandez TL, et al. The metabolic syndrome. Endocr Rev. 2008;29(7):777-822. https://doi.org/10.1210/er.2008-0024
  5. Hollman G, Kristenson M. The prevalence of the metabolic syndrome and its risk factors in a middle-aged Swedish population-mainly a function of overweight? Eur J Cardiovasc Nurs. 2008;7(1):21-26. https://doi.org/10.1016/j.ejcnurse.2007.05.003
  6. Hillier TA, Fagot-Campagna A, Eschwège E, Vol S, Cailleau M, Balkau B. Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort. Int J Epidemiol. 2006;35(1):190-196. https://doi.org/10.1093/ije/dyi281
  7. do Carmo I, Dos Santos O, Camolas J, et al. Overweight and obesity in Portugal: national prevalence in 2003-2005. Obes Rev. 2008;9(1):11-19. https://doi.org/10.1111/j.1467-789X.2007.00422.x
  8. Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008;105(44):17046-17049. https://doi.org/10.1073/pnas.0806560105
  9. Salas-Salvadó J, Bulló M, Estruch R, et al. Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial. Ann Intern Med. 2014;160(1):1-10. https://doi.org/10.7326/m13-1725
  10. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80(6 Suppl):1678s-1688s. https://doi.org/10.1093/ajcn/80.6.1678S
  11. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88(7):720-755. https://doi.org/10.1016/j.mayocp.2013.05.011
  12. Holick MF. Vitamin D: a millenium perspective. J Cell Biochem. 2003;88(2):296-307. https://doi.org/10.1002/jcb.10338
  13. Lips P, Eekhoff M, van Schoor N, et al. Vitamin D and type 2 diabetes. J Steroid Biochem Mol Biol. 2017;173:280-285. https://doi.org/10.1016/j.jsbmb.2016.11.021
  14. Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol. 2018;175:177-189. https://doi.org/10.1016/j.jsbmb.2016.09.017
  15. Ahmadi F, Damghani S, Lessan-Pezeshki M, Razeghi E, Maziar S, Mahdavi-Mazdeh M. Association of low vitamin D levels with metabolic syndrome in hemodialysis patients. Hemodial Int. 2016;20(2):261-269. https://doi.org/10.1111/hdi.12316
  16. Kim KJ, Kim YJ, Kim SH, et al. Vitamin D status and associated metabolic risk factors among North Korean refugees in South Korea: a cross-sectional study. BMJ Open. 2015;5(11):e009140. https://doi.org/10.1136/bmjopen-2015-009140
  17. Mitri J, Nelson J, Ruthazer R, et al. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. Eur J Clin Nutr. Mar 2014;68(3):376-383. https://doi.org/10.1038/ejcn.2013.293
  18. Barcelo A, Esquinas C, Pierola J, et al. Vitamin D status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration. 2013;86(4):295-301. https://doi.org/10.1159/000342748
  19. Lim HS, Kim TH, Lee HH, Kim SK, Lee B, Park YH. Relationship between serum 25-hydroxy-vitamin D concentration and risk of metabolic syndrome in patients with fatty liver. J Bone Metab. 2017;24(4):223-228. https://doi.org/10.11005/jbm.2017.24.4.223
  20. Akter S, Eguchi M, Kurotani K, et al. Serum 25-hydroxyvitamin D and metabolic syndrome in a Japanese working population: the Furukawa Nutrition and Health Study. Nutrition. 2017;36:26-32.
  21. Sung K-C, Chang Y, Ryu S, Chung H-K. High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men. Cardiovascular Diabetology. 2016;15(1):1-13. http://dx.doi.org/10.1186/s12933-016-0432-3
  22. Pham TM, Ekwaru JP, Setayeshgar S, Veugelers PJ. The effect of changing serum 25-hydroxyvitamin D concentrations on metabolic syndrome: a longitudinal analysis of participants of a preventive health program. Nutrients. 2015;7(9):7271-7284. https://doi.org/10.3390/nu7095338
  23. Vitezova A, Zillikens MC, van Herpt TT, et al. Vitamin D status and metabolic syndrome in the elderly: the Rotterdam study. Eur J Endocrinol. 2015;172(3):327-335. https://doi.org/10.1530/eje-14-0580
  24. Piantanida E, Gallo D, Veronesi G, et al. Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role? Endocr Connect. 2017;6(8):943-951. https://doi.org/10.1530/ec-17-0304
  25. Chun H, Kim GD, Doo M. Differences in the association among the vitamin D concentration, dietary macronutrient consumption, and metabolic syndrome depending on pre-and postmenopausal status in Korean women: a cross-sectional study. Diabetes Metab Syndr Obes Targets Ther. 2020;13:3601-3609.
  26. Kim J. Association between serum vitamin D, parathyroid hormone and metabolic syndrome in middle-aged and older Korean adults. Eur J Clin Nutr. 2015;69(4):425-430.
  27. Kim SH, Oh JE, Song DW, et al. The factors associated with vitamin D deficiency in community dwelling elderly in Korea. Nutr Res Pract. 2018;12(5):387-395.
  28. Jung C-H, Mok J-O, Chang SW, et al. Differential impacts of serum vitamin D levels and age at menarche on metabolic syndrome in premenopausal and postmenopausal women: findings from the Korea national cohort. Nutr Res. 2018;55:21-32.
  29. Yoon H, Bae NY, Gi MY, Park BY, Seong JM. The association between serum ferritin and 25-hydroxyvitamin D and metabolic syndrome in Korean women: the Korea National Health and Nutrition Examination Survey 2010-2012. J Clin Biochem Nutr. 2017;61(1):60-66.
  30. Yoon H, Kim GS, Kim SG, Moon AE. The relationship between metabolic syndrome and increase of metabolic syndrome score and serum vitamin D levels in Korean adults: 2012 Korean National Health and Nutrition Examination Survey. J Clin Biochem Nutr. 2015;57(1):82-87.
  31. Chung J-Y, Hong S-H. Vitamin D status and its association with cardiometabolic risk factors in Korean adults based on a 2008-2010 Korean National Health and Nutrition Examination Survey. Nutr Res Pract. 2013;7(6):495-502.
  32. Chon SJ, Yun BH, Jung YS, et al. Association between vitamin D status and risk of metabolic syndrome among Korean postmenopausal women. PLoS One. 2014;9(2):e89721.
  33. Kim M-H, Lee J, Ha J, et al. Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function. Sci Rep. 2018;8(1):1-8.
  34. Kim S, Lim J, Kye S, Joung H. Association between vitamin D status and metabolic syndrome risk among Korean population: based on the Korean National Health and Nutrition Examination Survey IV-2, 2008. Diabetes Res Clin Pract. 2012;96(2):230-236.
  35. Tran BT, Jeong BY, Oh J-K. The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults: results from the Korean National Health and Nutrition Examination Survey 2008-2013. BMC Public Health. 2017;17(1):71.
  36. Ganji V, Tangpricha V, Zhang X. Serum vitamin D concentration ≥75 nmol/L is related to decreased cardiometabolic and inflammatory biomarkers, metabolic syndrome, and diabetes; and increased cardiorespiratory fitness in US adults. Nutrients. 2020;12(3):730.
  37. Zhang X-E, Cheng B, Wang Q, Wan J-J. Association of gender-specific risk factors in metabolic and cardiovascular diseases: an NHANES-based cross-sectional study. J Invest Med. 2018;66(1):22-31.
  38. Ford ES, Zhao G, Li C, Pearson WS. Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States. J Diabetes. 2009;1(4):296-303.
  39. Maki KC, Fulgoni VL III, Keast DR, Rains TM, Park KM, Rubin MR. Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in US adults: National Health and Nutrition Examination Surveys 2003-2006. Metab Syndr Relat Disord. 2012;10(5):363-372.
  40. Reis JP, von Muhlen D, Miller ER. Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol. 2008;159(1):41-48.
  41. Al-Khalidi B, Kimball SM, Rotondi MA, Ardern CI. Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in US adults: a cross-sectional analysis of NHANES, 2001-2010. Nutr J. 2017;16(1):16.
  42. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among US adults. Diabetes Care. 2005;28(5):1228-1230.
  43. Kim H-S, Rotundo L, Kothari N, Kim S-H, Pyrsopoulos N. Vitamin D is associated with severity and mortality of non-alcoholic fatty liver disease: a US population-based study. J Clin Transl Hepatol. 2017;5(3):185-192.
  44. Yeap BB, Dedic D, Budgeon CA, et al. U-shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25-hydroxyvitamin D with metabolic syndrome risk. Intern Med J. 2020;50(4):460-469.
  45. Weldegiorgis TZ, Hidru TH, Yang XL, Xia YL, Ma L, Li HH. Association between serum 25-hydroxyvitamin D concentrations and metabolic syndrome in the middle-aged and elderly Chinese population in Dalian, northeast China: a cross-sectional study. J Dia Invest. 2020;11(1):184-191.
  46. Liu L, Cao Z, Lu F, et al. Vitamin D deficiency and metabolic syndrome in elderly Chinese individuals: evidence from CLHLS. Nutrition & Metabolism. 2020;17:58(1):1-11.
  47. Jeenduang N, Plyduang T, Horpet D. Association of 25-hydroxyvitamin D levels and metabolic syndrome in Thai postmenopausal women. Diabetes Metab Syndr Clin Res Rev. 2020;14(6):1585-1590.
  48. Ganji V, Sukik A, Alaayesh H, Rasoulinejad H, Shraim M. Serum vitamin D concentrations are inversely related to prevalence of metabolic syndrome in Qatari women. Biofactors. 2020;46(1):180-186.
  49. Mutt SJ, Jokelainen J, Sebert S, et al. Vitamin D status and components of metabolic syndrome in older subjects from Northern Finland (latitude 65 North). Nutrients. 2019;11(6):1229.
  50. Mehri Z, Salehi-Abargouei A, Shahvazi S, Samadi M, Zare F, Nadjarzadeh A. The association between vitamin D status and metabolic syndrome and its components among female teachers residing in Yazd city. Endocr Diab Nutr. 2019;66(10):628-638.
  51. Lee SJ, Lee EY, Lee JH, et al. Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: the Korean Urban Rural Elderly cohort study. BMC Geriatr. 2019;19(1):102.
  52. Chen L-W, Chien C-H, Kuo S-F, Yu C-Y, Lin C-L, Chien R-N. Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study. BMC Gastroenterol. 2019;19(1):126.
  53. Chen C, Chen Y, Weng P, et al. Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study. Nutr J. 2019;18(1):61.
  54. Wang C-M, Chang C-S, Chang Y-F, et al. Inverse relationship between metabolic syndrome and 25-hydroxyvitamin D concentration in elderly people without vitamin D deficiency. Sci Rep. 2018;8(1):1-10.
  55. Mogili KD, Karuppusami R, Thomas S, Chandy A, Kamath MS, Aleyamma T. Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome-a prospective observational study. Eur J Obstet Gynecol Reprod Biol. 2018;229:15-19.
  56. Sotunde OF, Kruger HS, Wright HH, et al. Association of 25-hydroxyvitamin D and parathyroid hormone with the metabolic syndrome in black South African women. Appl Physiol Nutr Metab. 2017;42(4):413-419.
  57. Raposo L, Martins S, Ferreira D, Guimarães JT, Santos AC. Vitamin D, parathyroid hormone and metabolic syndrome-the PORMETS study. BMC Endocr Disord. 2017;17(1):71
  58. Pannu PK, Zhao Y, Soares MJ, Piers LS, Ansari Z. The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey. Public Health Nutr. 2017;20(10):1785-1796.
  59. Pan G-T, Guo J-F, Mei S-L, et al. Vitamin D deficiency in relation to the risk of metabolic syndrome in middle-aged and elderly patients with type 2 diabetes mellitus. J Nutr Sci Vitaminol. 2016;62(4):213-219.
  60. Lally J, Gardner-Sood P, Firdosi M, et al. Clinical correlates of vitamin D deficiency in established psychosis. BMC Psychiatry. 2016;16(1):76.
  61. Chen L-W, Chien C-Y, Hsieh C-W, et al. The associations between Helicobacter pylori infection, serum vitamin D, and metabolic syndrome: a community-based study. Medicine. 2016;95(18):e3616.
  62. Lu Y, Liu M, Pei Y, et al. Low levels of serum 25-hydroxyvitamin D and risk of metabolic syndrome in China. Int J Clin Exp Med. 2015;8(8):13790-13796.
  63. Lerchbaum E, Schwetz V, Nauck M, Völzke H, Wallaschofski H, Hannemann A. Lower bone turnover markers in metabolic syndrome and diabetes: the population-based Study of Health in Pomerania. Nutr Metab Cardiovasc Dis. 2015;25(5):458-463.
  64. Bea JW, Jurutka PW, Hibler EA, et al. Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism. 2015;64(3):447-459.
  65. Mitri J, Nelson J, Ruthazer R, et al. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. Eur J Clin Nutr. 2014;68(3):376-383.
  66. Kayaniyil S, Harris SB, Retnakaran R, et al. Prospective association of 25(OH)D with metabolic syndrome. Clin Endocrinol (Oxf). 2014;80(4):502-507.
  67. González-Molero I, Rojo G, Morcillo S, et al. Relación entre déficit de vitamina D y síndrome metabólico. Med Clin. 2014;142(11):473-477.
  68. Dong J, Wang Q, Chen M-H, et al. Associations between serum-intact parathyroid hormone, serum 25-hydroxyvitamin D. Oral vitamin D analogs and metabolic syndrome in peritoneal dialysis patients: a multi-center cross-sectional study. Perit Dial Int. 2014;34(4):447-455.
  69. Amirbaigloo A, Hosseinpanah F, Sarvghadi F, Tohidi M, Eskandary PS, Azizi F. Absence of association between vitamin D deficiency and incident metabolic syndrome: Tehran Lipid and Glucose Study. Metab Syndr Relat Disord. 2013;11(4):236-242.
  70. Gagnon C, Lu ZX, Magliano DJ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metabol. 2012;97(6):1953-1961.
  71. Majumdar V, Nagaraja D, Christopher R. Vitamin D status and metabolic syndrome in Asian Indians. Int J Obes (Lond). 2011;35(8):1131-1134.
  72. Kim MK, Il Kang M, Won Oh K, et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol (Oxf). 2010;73(3):330-338.
  73. Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009;32(7):1278-1283.
  74. Lee DM, Rutter MK, O'Neill TW, et al. Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. Eur J Endocrinol. 2009;161(6):947-954.
  75. Hyppönen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes. 2008;57(2):298-305.
  76. Reis JP, Von Mühlen D, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 2007;30(6):1549-1555.
  77. Cota GF, de Sousa MR, Fereguetti TO, Rabello A. Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. PLoS Negl Trop Dis. 2013;7(5):e2195. https://doi.org/10.1371/journal.pntd.0002195
  78. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992;135(11):1301-1309.
  79. Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose-response data. The Stata J. 2006;6(1):40-57.
  80. Expert Panel on Detection E. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.
  81. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683-689.
  82. Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37(4):917-923.
  83. Thorn LM, Forsblom C, Wadén J, et al. Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes. Diabetes Care. 2009;32(5):950-952.
  84. Li X, Li X, Lin H, et al. Metabolic syndrome and stroke: a meta-analysis of prospective cohort studies. J Clin Neurosci. 2017;40:34-38.
  85. Vanhanen M, Koivisto K, Moilanen L, et al. Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology. 2006;67(5):843-847.
  86. Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402-2411.
  87. Ju SY, Jeong HS, Kim DH. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab. 2014;99(3):1053-1063.
  88. Saneei P, Salehi-Abargouei A, Esmaillzadeh A. Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis. Obes Rev. 2013;14(5):393-404.
  89. Poel Y, Hummel P, Lips P, Stam F, Van Der Ploeg T, Simsek S. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med. 2012;23(5):465-469.
  90. Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Springer. 2013;205-221.
  91. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010;65(3):225-236.
  92. Song D, Deng Y, Liu K, et al. Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies. Aging (Albany NY). 2019;11(24):12708.-12732.
  93. Pilz S, Iodice S, Zittermann A, Grant WB, Gandini S. Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies. Am J Kidney Dis. 2011;58(3):374-382.
  94. Hajhashemy Z, Shahdadian F, Ziaei R, Saneei P. Serum vitamin D levels in relation to abdominal obesity: a systematic review and dose-response meta-analysis of epidemiologic studies. Obes Rev. 2021;22(2):e13134.
  95. Earthman C, Beckman L, Masodkar K, Sibley S. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes (Lond). 2012;36(3):387-396.
  96. Maestro B, Campión J, Dávila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000;47(4):383-391.
  97. Mead JR, Irvine SA, Ramji DP. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med. 2002;80(12):753-769.
  98. Jafari T, Fallah AA, Barani A. Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: a meta-analysis of randomized controlled trials. Clin Nutr. 2016;35(6):1259-1268.
  99. Pilz S, Tomaschitz A, Ritz E, Pieber TR. Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol. 2009;6(10):621-630.
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