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3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020

Effects of a single dose of vitamin D in septic children: a randomized, double-blinded, controlled trial

Journal of International Medical Research https://doi.org/10.1177/0300060520926890
Yu Wang, Zhongwen Yang, Li Gao, Zhenfeng Cao, Qianhan Wang


Septic Shock: 6.7% vs 20%
Vitamin D levels 12 ng ==> 22 ng
If enough vitamin D had been given to raise the levels to >30 ng (300,000 IU?)
   perhaps 5X less Septic Shock instead of 3X

Sepsis is both prevented and treated by Vitamin D - many studies

Loading Dose of Vitamin D category has the following

199 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 62 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

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 Download the PDF from VitaminDWiki

To assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.

In this randomized, controlled trial, eligible children with VDD and sepsis were assigned to receive one dose of 150,000 IU of cholecalciferol or placebo. Serum concentrations of 25OHD, angiotensin-II (Ang-II), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were assessed at baseline and 8 days after treatment. The cardiovascular Sequential Organ Failure Assessment (cv-SOFA) score, septic shock incidence, duration of ventilation, and mortality were also examined.

One hundred nine participants fulfilled the study requirements. The two groups had comparable baseline characteristics. Ang-II, IL-6, and TNF-α concentrations were all reduced after vitamin D supplementation. Furthermore, the cv-SOFA score (1.76 ± 0.8 vs. 2.3 ± 1.1) and incidence of septic shock (7% vs. 20%) were lower in the treatment group than in the control group. The duration of ventilation and mortality rates did not differ between two groups.

A single dose of vitamin D improved 25OHD levels and the incidence of septic shock in children with VDD and sepsis.

Created by admin. Last Modification: Wednesday August 30, 2023 15:23:26 GMT-0000 by admin. (Version 5)

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13879 Sepsis child RCT 150,000 IU.pdf admin 03 Jun, 2020 296.67 Kb 395