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3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020

Effects of a single dose of vitamin D in septic children: a randomized, double-blinded, controlled trial

Journal of International Medical Research https://doi.org/10.1177/0300060520926890
Yu Wang, Zhongwen Yang, Li Gao, Zhenfeng Cao, Qianhan Wang

VitaminDWiki

Septic Shock: 6.7% vs 20%
Vitamin D levels 12 ng ==> 22 ng
If enough vitamin D had been given to raise the levels to >30 ng (300,000 IU?)
   perhaps 5X less Septic Shock instead of 3X


Vitamin D reduces sepsis


Loading Dose of Vitamin D category has the following

149 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Injection category listing has 53 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses

The TOP articles in Loading Dose of Vitamin D are listed here:


Items in both categories Trauma and Loading Dose are listed here:


Items in both categories Children and Loading Dose are listed here:

 Download the PDF from VitaminDWiki


Objective
To assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.

Methods
In this randomized, controlled trial, eligible children with VDD and sepsis were assigned to receive one dose of 150,000 IU of cholecalciferol or placebo. Serum concentrations of 25OHD, angiotensin-II (Ang-II), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were assessed at baseline and 8 days after treatment. The cardiovascular Sequential Organ Failure Assessment (cv-SOFA) score, septic shock incidence, duration of ventilation, and mortality were also examined.

Results
One hundred nine participants fulfilled the study requirements. The two groups had comparable baseline characteristics. Ang-II, IL-6, and TNF-α concentrations were all reduced after vitamin D supplementation. Furthermore, the cv-SOFA score (1.76 ± 0.8 vs. 2.3 ± 1.1) and incidence of septic shock (7% vs. 20%) were lower in the treatment group than in the control group. The duration of ventilation and mortality rates did not differ between two groups.

Conclusions
A single dose of vitamin D improved 25OHD levels and the incidence of septic shock in children with VDD and sepsis.


Created by admin. Last Modification: Wednesday June 3, 2020 18:30:41 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13879 Sepsis child RCT 150,000 IU.pdf PDF 2020 admin 03 Jun, 2020 18:19 296.67 Kb 27
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