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600,000 IU of vitamin D2 every 4 months for decades in East Germany – 1987

Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus.

Am J Clin Nutr. 1987 Oct;46(4):652-8.
Markestad T, Hesse V, Siebenhuner M, Jahreis G, Aksnes L, Plenert W, Aarskog D.
Department of Pediatrics, University of Bergen, Norway.

In infants receiving intermittent high dose vitamin D prophylaxis (600,000 IU ergocalciferol per dose orally) every 3-5 mo, the serum concentrations of vitamin D metabolites, calcium (Ca), and phosphorus (P) were determined before and 2 wk after each dose. The 25-hydroxyvitamin D (OHD) concentrations increased to well above normal but the values returned to the normal range before each subsequent dose. The 24,25- and 25,26-dihydroxyvitamin D ([OH]2D) levels followed a pattern similar to that of 25-OHD, and both were closely related to the latter (r = 0.85, p less than 0.005, and r = 0.84, p less than 0.005, respectively). The 1,25-(OH)2D concentrations did not vary in a consistent pattern and remained largely within the normal range. All infants had normal Ca levels before the first dose but 14 infants (34%) later had one or both Ca values above the upper normal limit of 2.80 mmol/L (2.81-3.32 mmol/L), indicating that the vitamin D doses were excessive despite the lack of accumulative increases in serum vitamin D concentrations.

PMID: 3499065

PDF is attached at bottom of this page

This study was cited 109 times in Google Scholar as of Aug 2021

Four reasons why this is a poor example for high dose vitamin D

  1. Totally missed taking the co-factors – and probably had too much Calcium
  2. 4 Months is too long a time between doses, even for D3, and vitamin D2 decays away more quickly
    The body gets very unbalanced by the huge fluctuations in Vitamin D levels
  3. Vitamin D2 is not nearly as good as Vitamin D3
  4. Far too large of a dose - even if considered as a daily average

600,000 IU over 90 days {actually 60 to 150 days} = 6,000 IU daily average = way too much for infants

See also VitaminDWiki

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475


See also: Vitamin D Council on ALL German Infants getting 600,000 IU of vitamin D2 three times a year.

3,000,000 children = about 150,000 births per year X 20 years
18,000,000 doses = children X 6

Short url = is.gd/VitD600000

Attached files

ID Name Comment Uploaded Size Downloads
4634 High dose 1987.pdf PDF admin 25 Nov, 2014 19:07 1.27 Mb 843