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COVID death 6.9X less likely if high Magnesium to Calcium ratio – April 2022


Magnesium-to-Calcium Ratio and Mortality from COVID-19

Nutrients 2022, 14(9), 1686; https://doi.org/10.3390/nu14091686

  • 1 Biomedical Research Unit, Instituto Mexicano del Seguro Social, Durango 34067, Mexico
  • 2 Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico
  • 3 Department of Internal Medicine, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico


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Obesity, type 2 diabetes, arterial hypertension, decrease in immune response, cytokine storm, endothelial dysfunction, and arrhythmias, which are frequent in COVID-19 patients, are associated with hypomagnesemia. Given that cellular influx and efflux of magnesium and calcium involve the same transporters, we aimed to evaluate the association of serum magnesium-to-calcium ratio with mortality from severe COVID-19. The clinical and laboratory data of 1064 patients, aged 60.3 ± 15.7 years, and hospitalized by COVID-19 from March 2020 to July 2021 were analyzed. The data of 554 (52%) patients discharged per death were compared with the data of 510 (48%) patients discharged per recovery. The ROC curve showed that the best cut-off point of the magnesium-to-calcium ratio for identifying individuals at high risk of mortality from COVID-19 was 0.20. The sensitivity and specificity were 83% and 24%.
The adjusted multivariate regression model showed that the odds ratio between the magnesium-to-calcium ratio ≤0.20 and discharge per death from COVID-19 was

  • 6.93 (95%CI 1.6–29.1) in the whole population,
  • 4.93 (95%CI 1.4–19.1, p = 0.003) in men, and
  • 3.93 (95%CI 1.6–9.3) in women.
    • ''Suspect a mistake was made: Have not seen an average to be greater thanthe items being averaged''

In conclusion, our results show that a magnesium-to-calcium ratio ≤0.20 is strongly associated with mortality in patients with severe COVID-19.
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