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Vitamin Supplementation and Dementia - Review May 2022


Vitamin Supplementation and Dementia: A Systematic Review

Nutrients 2022,14, 1033. https://doi.org/10.3390/ nu14051033
Victoria Gil Martinez 1 , Ana Avedillo Salas 2 and Sonia Santander Ballestin soniasb at unizar.es
Department of Geriatric Care, Bonifatius Hospital Lingen, 49808 Lingen, Germany; victoriiagil at gmail.com
Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine,
University of Zaragoza, 50009 Zaragoza, Spain; aave60 at hotmail.com

Background: Dementia is a syndrome characterized by progressive cognitive impairment that interferes with independent function in daily activities. Symptoms of dementia depend on its cause and vary greatly between individuals. There is extensive evidence supporting a relationship between diet and cognitive functions. This systematic review studies the efficacy of using vitamin supplements in the diet as a solution to nutritional deficiencies and the prevention of dementia and mild cognitive impairment. Methods: An intensive search of different databases (PubMed, Web of Science, and Cochrane CENTRAL) was performed. Articles that were published between 2011 and November 2021 were retrieved using the mentioned search strategy. This systematic review has been conducted according to the PRISMA statement.

Results: Folic acid supplementation proved to have better outcomes on cognitive tests than their respective control groups. The combined supplementation of folic acid and vitamin B12 showed some discrepancies between studies. Thiamine as supplementation did not only prove to have a positive impact on cognitive performance when given alone but also when given in combination with folic acid. Regarding vitamin D supplementation, the results observed were not so encouraging. A concomitant supplementation of low-dose vitamin E and vitamin C was also not associated with an improvement of cognitive function.

Conclusions: The findings of this systematic review suggest that supplementation of B Complex vitamins, especially folic acid, may have a positive effect on delaying and preventing the risk of cognitive decline. Ascorbic acid and a high dose of vitamin E, when given separately, also showed positive effects on cognitive performance, but there is not sufficient evidence to support their use. The results of vitamin D supplementation trials are not conclusive in assessing the potential benefits that vitamin D might have on cognition.
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The four main ones are Alzheimer’s disease, vascular, frontotemporal lobar degeneration, and Lewy body
Conclusions
  • The findings of this systematic review suggest that supplementation of B Complex vitamins, especially a supplementation of folic acid, may have a positive effect on delaying and preventing the risk of cognitive decline.
  • Ascorbic acid and a high dose of vitamin E also showed positive effects on cognitive performance. However, due to the small number of studies included in this systematic review about these vitamins, there is not sufficient evidence to support their use.
  • Regarding vitamin D supplementation, the findings observed vary vastly among trials. This results in a lack of certainty in assessing the potential benefits that vitamin D might have on cognition.

Note: Only one study used enough Vitamin D that had a chance of making a difference

VitaminDWiki pages with DEMENTIA in title (41 as of May 2022)

This list is automatically updated

Items found: 41
Title Modified
Vitamin Supplementation and Dementia - Review May 2022 11 May, 2022
Lewy Body Dementia (Robin Williams) and low Vitamin D 11 May, 2022
Dementia is associated with low vitamin D - several studies 23 Apr, 2022
Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 07 Apr, 2022
Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 07 Apr, 2022
Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 14 Feb, 2022
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 19 Aug, 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 08 Jan, 2021
The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 09 May, 2019
Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 04 Feb, 2019
Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 17 Jan, 2019
Why dementia gets more severe in the winter – Jan 2019 14 Jan, 2019
Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 07 Dec, 2018
Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 21 Aug, 2018
Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 02 Aug, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
Dementia less likely with increased levels of Magnesium etc. 18 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Should you have a dementia advanced directive - Jan 2018 19 Jan, 2018
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 15 Nov, 2017
Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 15 Jan, 2017
Dementia 19X more likely if low vitamin D – Jan 2012 27 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 04 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 04 Oct, 2016
Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 11 Dec, 2015
Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 01 Nov, 2015
Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 03 Oct, 2015
Dementia 13X more likely in elderly with low vitamin D – May 2014 04 Sep, 2015
Dementia risk increases with latitude (less vitamin D) - Feb 2015 20 Feb, 2015
Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015 04 Feb, 2015
The Single Vitamin That's a Double Whammy Against Both Depression and Dementia (Mercola) – Aug 2014 21 Aug, 2014
More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014 31 Jul, 2014
Age-adjusted dementia may be declining – NEJM Dec 2013 01 Jan, 2014
Dementia risk increases 60 percent if have low vitamin D – Nov 2012 16 Dec, 2013
Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013 01 Aug, 2013
Vitamin D might might reduce dementia – Mar 2011 23 Jun, 2012



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