Modifiable Risk Factors for Young-Onset Dementia Flagged
MDEdge
- "The study included 356,052 participants younger than 65 years (mean baseline age, 54.6 years) without dementia from the UK Biobank, an ongoing prospective cohort study."
- "During a mean follow-up of 8.12 years, there were 485 incident YOD cases (incidence rate of 16.8 per 100,000 person-years; 95% CI 15.4-18.3)."
- "The final analysis identified 15 risk factors associated with significantly higher incidence of YOD, including traditional factors like
- stroke (hazard ratio HR, 2.07),
- heart disease (HR, 1.61),
- diabetes (HR, 1.65), and
- depression (HR, 3.25) but also less-recognized risk factors like
- vitamin D deficiency (< 10 ng/mL; HR, 1.59),
- high CRP levels (> 1 mg/dL; HR, 1.54),
- and social isolation (infrequent visits to friends or family; HR, 1.53),
- with lower socioeconomic status (HR, 1.82),
- having two apolipoprotein E epsilon-4 alleles (HR, 1.87),
- orthostatic hypotension, which the authors said may be an early sign of Parkinson's dementia or Lewy body dementia (HR, 4.20), and
- hearing impairment (HR, 1.56) also increases risk."
Suspect they "adjusted" Vitamin D for stroke, diabetes, depression - all associated with Low Vitamin D
Suspect "unadjusted" Vitamin D is > 3X
Reporting on: Risk Factors for Young-Onset Dementia in the UK Biobank
Stevie Hendriks, PhD1; Janice M. Ranson, PhD2; Kirsten Peetoom, PhD1
The abstract is data-free. The PDF is not free: it costs $40 doi:10.1001/jamaneurol.2023.4929
PDF can be read at DeepDyve
7+ VitaminDWiki pages have EARLY-ONSET in the title
This list is automatically updated
Items found: 8
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Early-Onset diseases and Vitamin D - several studies |
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10 Apr, 2024 |
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30% increase in early-onset cancers expected in a decade – March 2023 |
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14 Mar, 2024 |
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Increased risk of early-onset Solid Cancer if family member had one: 7.3X if black, 3 X if white – June 2021 |
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14 Mar, 2024 |
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Increased risk of early-onset Solid Cancer if family member had one: 7.3X if black, 3 X if white – June 2021 |
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14 Mar, 2024 |
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Early-Onset Dementia 1.6X more likely if low Vitamin D - Dec 2023 |
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12 Jan, 2024 |
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16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 |
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22 May, 2023 |
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Early-Onset Colorectal Cancer 2X less likely if consume more than 450 IU of Vitamin D daily – Aug 2021 |
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18 Aug, 2021 |
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Hypothesis: Early onset Parkinson's (LRRK2) can be prevented with vitamin D |
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11 Aug, 2014 |
57+ Vitamin D pages have "Dementia" in the title
Items found: 57
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Title |
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Modified |
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Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis March 2024 |
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11 Mar, 2024 |
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Early-Onset Dementia 1.6X more likely if low Vitamin D - Dec 2023 |
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12 Jan, 2024 |
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Dementia (vascular) risk increase 60% if take Folate with other B vitamins - Dec 2023 |
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16 Dec, 2023 |
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The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. |
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19 Aug, 2023 |
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Seniors taking vitamin D were 40% less likely to get dementia - Jan 2023 |
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28 Jul, 2023 |
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Poor bone health is a ‘robust’ dementia risk factor (both associated with Low vitamin D) - March 2023 |
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31 Mar, 2023 |
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Dementia 2.6 X more likely if very low Vitamin D – March 2023 |
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19 Mar, 2023 |
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The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 |
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12 Mar, 2023 |
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Dementia again associated with low Vitamin D – 15th study in 10 years – Jan 2023 |
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03 Mar, 2023 |
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Neurodegenerative diseases (AD, PD, MS, Dementia, etc.) fought by Vitamin D (in rodents) – Jan 2023 |
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24 Feb, 2023 |
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How Vitamin D fights neurodegeneration (Multiple Sclerosis, Alzheimer’s, Dementia, etc) – Jan 2023 |
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12 Jan, 2023 |
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Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022 |
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06 Jan, 2023 |
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Dementia is associated with low vitamin D - many studies |
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02 Jan, 2023 |
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Dementia 1.35 X more-likely if poor diet – Oct 2022 |
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13 Oct, 2022 |
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Doggie dementia 6.5X more likely if not get exercise (probably low vitamin D) - Aug 2022 |
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27 Aug, 2022 |
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Dementia 2X more likely after ICU (suspect low Vitamin D) - Aug 2022 |
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02 Aug, 2022 |
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Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022 |
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13 Jul, 2022 |
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Vitamin Supplementation and Dementia - Review May 2022 |
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11 May, 2022 |
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Lewy Body Dementia (Robin Williams) and low Vitamin D |
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11 May, 2022 |
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Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 |
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07 Apr, 2022 |
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Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 |
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07 Apr, 2022 |
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Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 |
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14 Feb, 2022 |
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Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 |
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22 Nov, 2021 |
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Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 |
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19 Aug, 2021 |
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Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 |
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08 Jan, 2021 |
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The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 |
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09 May, 2019 |
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Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 |
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04 Feb, 2019 |
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Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 |
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17 Jan, 2019 |
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Why dementia gets more severe in the winter – Jan 2019 |
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14 Jan, 2019 |
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Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 |
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07 Dec, 2018 |
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Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 |
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21 Aug, 2018 |
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Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 |
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02 Aug, 2018 |
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Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 |
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12 May, 2018 |
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Dementia less likely with increased levels of Magnesium etc. |
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18 Apr, 2018 |
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5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 |
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11 Apr, 2018 |
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Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before |
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18 Mar, 2018 |
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Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 |
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16 Feb, 2018 |
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Should you have a dementia advanced directive - Jan 2018 |
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19 Jan, 2018 |
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Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 |
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08 Dec, 2017 |
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Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 |
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23 Nov, 2017 |
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Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 |
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15 Nov, 2017 |
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Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 |
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15 Jan, 2017 |
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Dementia 19X more likely if low vitamin D – Jan 2012 |
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27 Oct, 2016 |
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The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 |
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04 Oct, 2016 |
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The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 |
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04 Oct, 2016 |
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Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 |
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11 Dec, 2015 |
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Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 |
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01 Nov, 2015 |
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Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 |
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03 Oct, 2015 |
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Dementia 13X more likely in elderly with low vitamin D – May 2014 |
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04 Sep, 2015 |
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Dementia risk increases with latitude (less vitamin D) - Feb 2015 |
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20 Feb, 2015 |
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Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015 |
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04 Feb, 2015 |
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The Single Vitamin That's a Double Whammy Against Both Depression and Dementia (Mercola) – Aug 2014 |
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21 Aug, 2014 |
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More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014 |
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31 Jul, 2014 |
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Age-adjusted dementia may be declining – NEJM Dec 2013 |
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01 Jan, 2014 |
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Dementia risk increases 60 percent if have low vitamin D – Nov 2012 |
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16 Dec, 2013 |
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Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013 |
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01 Aug, 2013 |
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Vitamin D might might reduce dementia – Mar 2011 |
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23 Jun, 2012 |