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Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018

Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease.

FASEB J. 2018 Oct 5:fj201801412R. doi: 10.1096/fj.201801412R.
Patrick RP University of California San Francisco Benioff, Children's Hospital Oakland Research Institute, Oakland, California, USA.

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Note: Some Omega-3 supplements are of the phospholipid form and so should get past the BBB

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COVID-19 fought by Vitamin D or Heat - Drs Seheult and Patrick video - March 3, 2021 07 Mar, 2021
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Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
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Off topic – Outline of 2 hour health webinar by Dr. Patrick – Oct 2017 12 Oct, 2017
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Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015

 Download the PDF from VitaminDWiki

Dietary and supplemental intake of the ω-3 fatty acid docosahexaenoic acid (DHA) reduces risk of Alzheimer's disease (AD) and ameliorates symptoms. The apolipoprotein E ( APOE) 4 allele is the strongest risk factor for sporadic AD, exclusive of age.
APOE4 carriers respond well to the DHA present in fish but do not respond as well to dietary supplements.
The mechanisms behind this varied response remain unknown. I posit that the difference is that fish contain DHA in phospholipid form, whereas fish oil supplements do not. This influences whether DHA is metabolized to nonesterified DHA (free DHA) or a phospholipid form called lysophosphatidylcholine DHA (DHA-lysoPC). Free DHA is transported across the outer membrane leaflet of the blood-brain barrier (BBB) via passive diffusion, and DHA-lysoPC is transported across the inner membrane leaflet of the BBB via the major facilitator superfamily domain-containing protein 2A.
I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a breakdown in the outer membrane leaflet of the BBB, putting them at increased risk for AD. Dietary sources of DHA in phospholipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk of AD


Created by admin. Last Modification: Saturday February 5, 2022 17:44:33 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
11085 Alz, Omega-3 Patrick.pdf admin 25 Dec, 2018 2.35 Mb 773