Vitamin D status and functional health outcomes in children aged 2-8 y: a 6-mo vitamin D randomized controlled trial.
Am J Clin Nutr. 2018 Mar 1;107(3):355-364. doi: 10.1093/ajcn/nqx062.
Brett NR1, Parks CA1, Lavery P1, Agellon S1, Vanstone CA1, Kaufmann M2, Jones G2, Maguire JL3, Rauch F4,5, Weiler HA1.
Items in both categories Intervention and Infant-Child are listed here:
- Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
- Toddlers with more than 48 ng of vitamin D weighted less and were thinner – RCT Dec 2020
- 6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT Sept 2018
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Tic disorder reduced by Vitamin D supplementation – Aug 2019
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- 400 IU of Vitamin D in food provided virtually no benefit to children - March 2018
- Children need 2000 IU of Vitamin D (India) - RCT May 2019
- Preterm babies have low vitamin D, but recover in 6 weeks with 800 IU supplementation – Jan 2019
- 1200 IU vs 400 IU of vitamin D did not improve bone health or immunity of children who were sufficient – RCT July 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- 400 IU of Vitamin D provided no benefit to children (not a surprise) – RCT March 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Preemies getting 800 IU of vitamin D were 3X less likely to have low bone density 4 weeks later – RCT Oct 2017
- Preemies need 1,000 IU of vitamin D – RCT Sept 2017
- Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017
- Premature infants (30 weeks) who got 800-1000 IU of vitamin D were much healthier – March 2017
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016
- Monthly 120,000 IU of Vitamin D during lactation worked well - May 2016
- Infant infection reduced by half with vitamin D supplementation – RCT May 2016
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016
- Breastfeeding mother getting 6400 IU of Vitamin D is similar to infant getting 400 IU – RCT Sept 2015
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Breast-feeding mothers need 2000 IU of vitamin D to get infants to even 12 ng – July 2015
- 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
- Growing pains reduced 57 percent by vitamin D therapy – May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- 50,000 IU Vitamin D one time after birth helped – RCT Jan 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- 2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT April 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- 800 IU vitamin D for infant and 2000 IU for mother is good, not great – RCT Dec 2013
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
BACKGROUND: Most Canadian children do not meet the recommended dietary intake for vitamin D.
The aims were to test how much vitamin D from food is needed to maintain a healthy serum 25-hydroxyvitamin D3 [25(OH)D3] status from fall to spring in young children and to examine musculoskeletal outcomes.
Healthy children aged 2-8 y (n = 51) living in Montreal, Canada, were randomly assigned to 1 of 2 dietary vitamin D groups (control or intervention to reach 400 IU/d by using vitamin D-fortified foods) for 6 mo, starting October 2014. At baseline and at 3 and 6 mo, anthropometric characteristics, vitamin D metabolites (liquid chromatography-tandem mass spectrometry), and bone biomarkers (IDS-iSYS, Immunodiagnositc Systems; Liaison; Diasorin) were measured and physical activity and food intakes surveyed. At baseline and at 6 mo, bone outcomes and body composition (dual-energy X-ray absorptiometry) were measured. Cross-sectional images of distal tibia geometry and muscle density were conducted with the use of peripheral quantitative computed tomography scans at 6 mo.
At baseline, participants were aged 5.2 ± 1.9 (mean ± SD) y and had a body mass index z score of 0.65 ± 0.12; 53% of participants were boys. There were no differences between groups in baseline serum 25(OH)D3 (66.4 ± 13.6 nmol/L) or vitamin D intake (225 ± 74 IU/d). Median (IQR) compliance was 96% (89-99%) for yogurt and 84% (71-97%) for cheese. At 3 mo, serum 25(OH)D3 was higher in the intervention group (P < 0.05) but was not different between groups by 6 mo. Although lean mass accretion was higher in the intervention group (P < 0.05), no differences in muscle density or bone outcomes were observed.
The consumption of 400 IU vitamin D/d from fall to spring did not maintain serum 25(OH)D3 concentration or improve bone outcomes. Further work with lean mass accretion as the primary outcome is needed to confirm if vitamin D enhances lean accretion in healthy young children. This trial was registered at www.clinicaltrials.gov as NCT02387892.