Vitamin D Intervention and Bone: A Randomized Clinical Trial in Fair- and Dark-skinned Children at Northern Latitudes.
J Pediatr Gastroenterol Nutr. 2018 Sep;67(3):388-394. doi: 10.1097/MPG.0000000000002031.
Items in both ofthe categories Infant-Child AND Bone are listed here:
- Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT Sept 2018
- Child abuse fractures – 96 percent were associated with poor bones (low vitamin D, etc.) – Oct 2019
- Spinal muscular atrophy - 2 million dollar drug or try Vitamin D - May 2019
- Breastfed infant bones not helped by 800 IU of Vitamin D (not enough) – RCT Dec 2017
- Large soft spot on infant’s head (anterior fontanelle) is associated with low vitamin D – Sept 2017
- Long-Term bedridden patients have poor vitamin D and poor bones – June 2017
- Low bone mineral density of male children is associated with low BMD of parents – Oct 2016
- Childhood Fractures – consensus report on vitamin D – Feb 2016
- 2,000 IU vitamin D recommended for pediatric rheumatology – May 2015
- Spinal muscular atrophy (rare disease) might be helped with vitamin D - June 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Child Bone health – (incorrect) recommendations by US Pediatric and Bone Health groups – Sept 2014
- Hip problem in boys (PERTHES' DISEASE) associated with low vitamin D – Jan 2014
- Low vitamin D associated with 5.5X increased risk of low bone mineral density – March 2013
- Bone health markers generally not improved by 550 IU of vitamin D after birth – July 2012
- Less child bone if mother lacked vitamin D – Dec 2010
- Lack of vitamin D in infants can result in broken bones and shaken baby syndrome - March 2010
Karlsland Åkeson P1, Åkesson KE2, Lind T3, Hernell O3, Silfverdal SA3, Öhlund I3.
1 Department of Clinical Sciences.
2 Clinical and Molecular Osteoporosis Research Unit, Orthopaedics, Lund University, Malmö.
3 Department of Clinical Sciences, Paediatrics, Umeå university, Umeå, Sweden.
The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter.
In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n = 206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25 μg, 10 μg, or placebo (2 μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25-hydroxy vitamin D (S-25OHD), and related parameters were analyzed.
Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P = 0.012) and TBLH (P = 0.002) and BMC of TBLH (P = 0.04) were higher at baseline and follow-up in those with dark skin. Delta (Δ) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25 μg (P = 0.038) and 10 μg (P = 0.027) groups compared to placebo. We found no associations between Δ S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and Δ BMD and BMC, respectively.
BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01741324.