The Effects of Vitamin D Supplementation During Infancy on Growth During the First Two Years of Life
J Clin Endocrinol Metab. 2020 Dec 21;dgaa943. doi: 10.1210/clinem/dgaa943
Helena H Hauta-Alus 1 2 3, Elisa M Holmlund-Suila 1 2, Eero Kajantie 1 3 4 5, Jenni Rosendahl 1 2, Saara M Valkama 1 2, Maria Enlund-Cerullo 1 2, Sture Andersson 1, Outi Mäkitie 1 6 7
Randomized Controlled Trial: 1200 IU daily vs 400 IU daily for 2 years
Note: 1200 IU is a nice dose size for the first 6 months, but not large enough later for many children
- Children need 2000 IU of Vitamin D (India) - RCT May 2019
- Infant-Child category listing has
846 items along with related searches - Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT May 2013
- which is a total of 48,000 IU every month
Monthly dosing works well, sometimes better than daily
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing is better than daily dosing for children and elderly (more likely to be taken) – June 2017
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
Context: The relationship between maternal and infant vitamin D and early childhood growth remains inadequately understood.Objective: To investigate how maternal and child 25-hydroxyvitamin D 25(OH)D and vitamin D supplementation impact growth during the first 2 years of life.
Design: A randomized, double-blinded intervention study.
Setting: A single-center study from pregnancy until offspring age 2 years.
Participants: Altogether 812 term-born children with complete data, recruited at Maternity Hospital.
Intervention: Children received daily vitamin D3 supplementation 10 μg (Group-10) or 30 μg (Group-30) from age 2 weeks to 2 years.
Main outcome measures: Anthropometry and growth rate at age 1 and 2 years.
Results: Toddlers born to mothers with Pregnancy 25(OH)D >125 nmol/L were at 2 years lighter and thinner than the reference group with 25(OH)D 50-74.9 nmol/L (P<0.010). Mean 2-year 25(OH)D concentrations were 87 nmol/L in Group-10 and 118 nmol/L in Group-30 (P<0.001). When Group-30 was compared with Group-10, difference in body size was not statistically significant (P>0.053), but Group-30 had slower growth in length and head circumference between 6 months and 1 year (P<0.047), and more rapid growth in weight and length-adjusted weight between 1 and 2 years (P<0.043).
Toddlers in the highest quartile of 25(OH)D (>121 nmol/L) were shorter (mean difference 0.2 SD score (SDS), P=0.021), lighter (mean difference 0.4 SDS, P=0.001) and thinner (in length-adjusted weight) (mean difference 0.4 SDS, P=0.003) compared with the lowest quartile (<81.2 nmol/L).Conclusion: Vitamin D and early childhood growth may have an inverse U-shaped relationship.
Toddlers with more than 48 ng of vitamin D weighted less and were thinner – RCT Dec 2020Printer Friendly Follow this page for updates4189 visitors, last modified 22 Dec, 2020, This page is in the following categories (# of items in each category) - Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT May 2013