Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight–Loss Programme—A Double Blind Randomized Placebo–Controlled Trial
Nutrients 2020, 12(4), 1093; https://doi.org/10.3390/nu12041093
by Michał Brzeziński 1,2,*OrcID,Agnieszka Jankowska 1,Magdalena Słomińska-Frączek 3,Paulina Metelska 2,4,Piotr Wiśniewski 5,Piotr Socha 6 andAgnieszka Szlagatys-Sidorkiewicz 1OrcID
After 25 weeks, 1200 IU of vitamin D daily raised Vitamin D blood levels of obese children from 19 to 25 ng
Benefits of Vitamin D are rarely seen for any health problem if levels are <30 ng
This trial would have been successful if it had given at least:
| Daily | or Weekly | |
| Children | 2,000 IU | 14,000 IU |
| Youths (heavier) | 3,000 IU | 21,000 IU |
Items in both categories Infant-Child and Obesity are listed here:
- Omega-3 added to father’s diet reduced offspring’s obesity (mice) – June 2024
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024
- Obese children had less gene methylation (gene not work as well) – March 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- High-dose Vitamin D reduced inflammation and insulin resistance (obese children) - Dec 2023
- Vitamin D half life is shorter in asthmatic children who are more obese – Nov 2023
- Childhood BMI decreased when add a little Vitamin D – meta-analysis March 2023
- Child Obesity and Vitamin D - many studies
- Recent increases in pediatric endocrine problems may be decreased by Vitamin D – Aug 2022
- Obese during childhood usually results in obese adult (M.R., not a surprise) - Aug 2022
- Less obese child if supplemented with Vitamin D as an infant– meta-analysis Feb 2021
- Obese children had 2.2 X less response to a single dose of Vitamin D – Oct 2020
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
- Obesity 3X more likely in US children having low vitamin D – July 2019
- Overweight children are 3.4 X more likely to have low Vitamin D – March 2019
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016
- Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations (5,000 IU) – Feb 2016
- Obese children – 71 percent had low vitamin D– Jan 2016
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Obese children and youths need more vitamin D – Review Feb 2015
- Overweight children associated with low vitamin D during pregnancy – 2015, 2018
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- More Hypertension in obese children with low vitamin D, especially at night – Dec 2013
- Very poor follow-thu with vitamin D testing and supplementation of obese children – June 2013
- Obese children gain weight more quickly when have low vitamin D – Oct 2013
- Obese mothers with adequate vitamin D gave birth to low D and fat infants – Jan 2013
- Heavier kids more vitamin D deficient, especially if dark skinned – Pediatrics Dec 2012
- Obese children with celiac disease had lower levels of vitamin D – April 2012
- The more vitamin D the lower the infant BMI – March 2011
- Obama task force told that childhood Obesity linked to Vitamin D Deficiency – Aug 2010
Items in both categories Intervention and Obesity are listed here:
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT) – March 2022
- Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D – June 2021
- Overweight elderly respond well to 3600 IU Vitamin D daily for a year – RCT May 2021
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- 2.3 X more weight loss in those who had low vitamin D levels and took some – Dec 2019
- Obese lost 3X more weight with Vitamin D - July 2018
- Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT June 2019
- Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks – May 2019
- Obese responded to weekly vitamin D better than non-obese – RCT March 2018
- Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT Dec 2018
- Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
- Lost 19 lbs more if add vitamin D to calorie restriction and walking program– July 2018
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Response by obese to weekly 50,000 IU of Vitamin D – May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Increased Testosterone and Erectile function, decreased weight with Vitamin D – March 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015
- 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT Feb 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- 50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013
- 50,000 IU vitamin D 1-3 times per week helped obese patients in rehab. – May 2013
- Obesity not reduced with 7,000 IU vitamin D daily – April 2013
- Higher BMI decreased response to 700 IU vitamin D – RCT 2008
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013
- 7000 IU vitamin D was not enough to reduce obese tissue – RCT Jan 2013
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
Download the PDF from VitaminDWiki
Background: Vitamin D was studied in regards to its possible impact on body mass reduction and metabolic changes in adults and children with obesity yet there were no studies assessing the impact of vitamin D supplementation during a weight management program in children and adolescence. The aim of our study was to assess the influence of 26 weeks of vitamin D supplementation in overweight and obese children undergoing an integrated 12–months’ long weight loss program on body mass reduction, body composition and bone mineral density.
Methods: A double–blind randomized placebo–controlled trial. Vitamin D deficient patients (<30 ng/ml level of vitamin D) aged 6–14, participating in multidisciplinary weight management program were randomly allocated to receiving vitamin D (1200 IU) or placebo for the first 26 weeks of the intervention.
Results: Out of the 152 qualified patients, 109 (72%) completed a full cycle of four visits scheduled in the program. There were no difference in the level of BMI (body mass index) change – both raw BMI and BMI centiles. Although the reduction of BMI centiles was greater in the vitamin D vs. placebo group (−4.28 ± 8.43 vs. −2.53 ± 6.10) the difference was not statistically significant (p = 0.319). Similarly the reduction in fat mass—assessed both using bioimpedance and DEXa was achieved, yet the differences between the groups were not statistically significant.
Conclusions: Our study ads substantial results to support the thesis on no effect of vitamin D supplementation on body weight reduction in children and adolescents with vitamin D insufficiency undergoing a weight management program.