Dissertation by Anna Vitezova, which includes many of her publications
170 page dissertation includes many of her Vitamin D publications
She appears to say that Vitamin D
- Reduces mortality
- Reduces metabolic syndrome
- Does not reduce atrial fibrillation (nope, Magnesium is needed)
- Reduces diabetes provided there is enough Magnesium
- Might be a cost-effective way to improve the overall health of a nation
See also VitaminDWiki
Search VitaminDWiki for VITEZOVA 28 items as of Oct 2015
Rotterdam Vitamin D dissertation text - Oct 2015 rough text, for translation
Overview Metabolic Syndrome and vitamin D
Overview Diabetes and vitamin D
Overview Magnesium and vitamin D
Overview Cardiovascular and vitamin D
Arrhythmia OR “atrial fibrillation” 337 items as of Oct 2015
(Arrhythmia OR “atrial fibrillation”) AND Magnesium 292 items as of Oct 201
Less likely to die if have enough vitamin D - Meta-analysis June 2014
All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015
click on image for details
Pages in VitaminDWiki listed in BOTH of the categories Diabetes and Magnesium
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
Chapter 1 of this thesis introduces the reader to the background of the main topic – vitamin D, its metabolism and physiological effects. Since its discovery vitamin D has been recognized as an important factor in calcium homeostasis and bone metabolism. Recently, there has been extensive research performed on possible extra-skeletal effects of vitamin D. Nowadays vitamin D deficiency has been linked to a higher risk of many prevalent diseases such as cardio-vascular disease or type 2 diabetes mellitus. Based on this new research it is considered that improving vitamin D status may be a cost-effective tool to improve public health. The main objective of this thesis was to investigate the association of vitamin D and cardio-metabolic health.
Chapter 2 presents a systematic review and meta-analysis of observational studies and randomised controlled trials (RCTs) on vitamin D and the risk of mortality. The objective was to evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality under various circumstances. With this meta-analysis we found that the evidence from observational studies shows inverse associations of circulating 25-hydroxyvitamin D with risks of vascular, cancer and nonvascular-noncancer deaths. Further we found that supplementation with vitamin D3 reduces overall mortality among older adults significantly; however, further investigations are required to establish the optimal dose and duration, and whether vitamin D3 affects mortality risk differently than vitamin D2.
In chapter 3 we investigated the associations between vitamin D and metabolic outcomes. More specifically, in chapter 3.1 we focused on possible association between vitamin D status and prevalence of metabolic syndrome in the elderly since the findings on this topic in the elderly are inconsistent. The aim was to evaluate the association between vitamin D status and the metabolic syndrome in the elderly, as well as between vitamin D status and the components of metabolic syndrome (i.e. serum glucose, triglycerides (TG), HDL cholesterol (HDL-C), waist circumference (WC), and blood pressure (BP)). We found higher 25-hydroxyvitamin D concentrations in the elderly to be associated with a lower prevalence of metabolic syndrome and, in particular, with more beneficial HDL-C, TG, WC and serum glucose. Further in this chapter (3.2) we examined the association between vitamin D and body composition in the elderly. We found lower serum 25-hydroxyvitamin D concentrations to be associated with a higher fat mass Vitamin D and Cardio-metabolic Health in the Elderly percentage. We also demonstrated that the association between serum 25-hydroxyvitamin D and differential fat distribution in the elderly was mainly explained by BMI, which deserves further study.
The focus of chapter 4 was on the association of vitamin D and cardiovascular health. Here we investigated the possible association between vitamin D status and the incidence of atrial fibrillation in the elderly. We found vitamin D status not to be associated with atrial fibrillation in any of the 3 multivariate models tested and concluded that this prospective cohort study did not support the hypothesis that vitamin D status is associated with atrial fibrillation.
Chapter 5 introduces new ideas in the vitamin D research. Firstly, we have investigated the possible interaction between serum magnesium levels and vitamin D in relation to incidence of type 2 diabetes mellitus (5.1). We found that the association between 25-hydroxyvitamin D and type 2 diabetes mellitus may depend on adequate serum magnesium levels. These results imply that it may be important in clinical practice to assess serum 25-hydroxyvitamin D and magnesium levels simultaneously to identify people at risk of type 2 diabetes mellitus. In the second part of chapter 5 (5.2), we explored the association between vitamin D and serum lipids. Higher levels of vitamin D have been associated with lower rates of cardiovascular disease perhaps through improved lipid profiles. However, results reported were inconsistent and the direction of the association between vitamin D and lipid levels remained unknown. For that reason the aim of this chapter was to assess the potential bidirectional associations between 25-hydroxyvitamin D and blood lipids using path analyses in cross-lagged models a novel approach in analyzing this kind of data. Our results from path analyses on repeatedly measured 25-hydroxyvitamin D and lipid levels suggest that total cholesterol might be related with a decrease in 25-hydroxyvitamin D concentrations, but not the other way around, whereas the observed inverse association between HDL cholesterol and 25-hydroxyvitamin D may be bidirectional.
Chapter 6 discusses the main findings of this thesis as well as methodological issues arising from the design of our study, public health implications of our findings and future directions in vitamin D research. Repletion of vitamin D status might be considered as a cost-effective public health measure in prevention of certain conditions and improving some aspects of overall human health. However, to prove the causality of the association of vitamin D Vitamin D and Cardio-metabolic Health in the Elderly and different diseases with the certainty, properly designed randomized controlled trials are needed.