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Vitamin D3 is stored in fat has not been processed by liver – March 2015

Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3.

Eur J Endocrinol. 2015 Mar;172(3):235-41. doi: 10.1530/EJE-14-0870.

VitaminDWiki Summary

29 diabetic subjects – who usually have more fatty tissue
20,000 IU D3 weekly for 3-5 years

serum 25(OH)D340 ng/ml
fat vitamin D3209ng/g
fat 25(OH)D33.8ng/g

50X more as unprocessed than liver-processed


Didriksen A1, Burild A2, Jakobsen J2, Fuskevåg OM2, Jorde R3.

  • 1Tromsø Endocrine Research Group Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway National Food Institute Technical University of Denmark, Søborg, Denmark Division of Diagnostic Services Division of Internal Medicine University Hospital of North Norway, 9038 Tromsø, Norway allan.didriksen at unn.no.
  • 2Tromsø Endocrine Research Group Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway National Food Institute Technical University of Denmark, Søborg, Denmark Division of Diagnostic Services Division of Internal Medicine University Hospital of North Norway, 9038 Tromsø, Norway.
  • 3Tromsø Endocrine Research Group Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayNational Food InstituteTechnical University of Denmark, Søborg, DenmarkDivision of Diagnostic ServicesDivision of Internal MedicineUniversity Hospital of North Norway, 9038 Tromsø, Norway Tromsø Endocrine Research GroupDepartment of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayNational Food InstituteTechnical University of Denmark, Søborg, DenmarkDivision of Diagnostic ServicesDivision of Internal MedicineUniversity Hospital of North Norway, 9038 Tromsø, Norway.


OBJECTIVE:
The objective was to assess the amount of vitamin D3 stored in adipose tissue after long-term supplementation with high dose vitamin D3.

DESIGN:
A cross-sectional study on 29 subjects with impaired glucose tolerance who had participated in a randomized controlled trial with vitamin D3 20 000 IU (500 μg) per week vs placebo for 3-5 years.

METHODS:
Abdominal subcutaneous fat tissue was obtained by needle biopsy for the measurements of vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3). Body fat was measured with dual-energy X-ray absorptiometry, and serum 25(OH)D3 level was quantified.

RESULTS:
In the subjects given vitamin D3, the median concentrations of serum 25(OH)D3, fat vitamin D3, and fat 25(OH)D3 were 99 nmol/l, 209 ng/g, and 3.8 ng/g, respectively; and correspondingly in the placebo group 62 nmol/l, 32 ng/g, and 2.5 ng/g. If assuming an equal amount of vitamin D3 stored in all adipose tissue in the body, the median body store was 6.6 mg vitamin D3 and 0.12 mg 25(OH)D3 in those given vitamin D3.

CONCLUSIONS:
Subcutaneous adipose tissue may store large amounts of vitamin D3. The clinical importance of this storage needs to be determined.

© 2015 European Society of Endocrinology.

PMID: 25661743

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http://vitamindwiki.com/tiki-index.php?page_id=5644

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