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Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015

Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial

Diabetes & Metabolism. doi:10.1016/j.diabet.2015.03.010, Available online 27 April 2015
F. Guerrero-Romero, L.E. Simental-Mendía, G. Hernández-Ronquillo, M. Rodriguez-Morán rodriguez.moran.martha at gmail.com

VitaminDWiki Summary

Patients had, like most people, low levels of Magnesium
382 mg of Magnesium element per day in the form of Magnesium Chloride for 4 months

Magnesium
Chloride
PlaceboUnits
follow-up fasting 87 98 mg/dL
post-load glucose 125 137 mg/dL
HOMA-IR indices 2.94.1
Triglycerides 166 227
Serum magnesium 2.0 1.6 mg/dL

Note: serum Magnesium tests cost > $100
Magnesium deficiency is exceeded only by Vitamin D deficiency globally
There are scores of reasons to restore Magnesium levels to where they were 50 years ago
See also VitaminDWiki

Pages listed in BOTH the categories Diabetes and Magnesium


PDF is available at deepdyve.com
Image

Aim
This study evaluated the efficacy of oral magnesium supplementation in the reduction of plasma glucose levels in adults with prediabetes and hypomagnesaemia.

Methods
A total of 116 men and non-pregnant women, aged 30 to 65 years with hypomagnesaemia and newly diagnosed with prediabetes, were enrolled into a randomized double-blind placebo-controlled trial to receive either 30 mL of MgCl2 5% solution (equivalent to 382 mg of magnesium) or an inert placebo solution once daily for four months. The primary trial endpoint was the efficacy of magnesium supplementation in reducing plasma glucose levels.

Results
At baseline, there were no significant statistical differences in terms of anthropometric and biochemical variables between individuals in the supplement and placebo groups. At the end of follow-up fasting (86.9 ± 7.9 and 98.3 ± 4.6 mg/dL, respectively; P = 0.004) and post-load glucose (124.7 ± 33.4 and 136.7 ± 23.9 mg/dL, respectively; P = 0.03) levels, HOMA-IR indices (2.85 ± 1.0 and 4.1 ± 2.7, respectively; P = 0.04) and triglycerides (166.4 ± 90.6 and 227.0 ± 89.7, respectively; P = 0.009) were significantly decreased, whereas HDL cholesterol (45.6 ± 10.9 and 46.8 ± 9.2 mg/dL, respectively; P = 0.04) and serum magnesium (1.96 ± 0.27 and 1.60 ± 0.26 mg/dL, respectively; P = 0.005) levels were significantly increased in those taking MgCl2 compared with the controls. A total of 34 (29.4%) people improved their glucose status (50.8% and 7.0% in the magnesium and placebo groups, respectively; P < 0.0005).

Conclusion
Our results show that magnesium supplementation reduces plasma glucose levels, and improves the glycaemic status of adults with prediabetes and hypomagnesaemia.

Attached files

ID Name Comment Uploaded Size Downloads
7723 Mg Diabetes.jpg admin 28 Jan, 2017 16:16 63.65 Kb 249
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