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Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014

Oral magnesium supplementation in type II diabetic patients.

Med J Islam Repub Iran. 2014 Jul 15;28:67. eCollection 2014.
Solati M1, Ouspid E2, Hosseini S3, Soltani N4, Keshavarz M5, Dehghani M6.

VitaminDWiki Summary
Day 0 3 months
Fasting Glucose Mg 184125
Fasting Glucose Placebo196136
After meal Glucose Mg239189
After meal Glucose Placebo246248


Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
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BACKGROUND:
Magnesium is the second most abundant intracellular cation. It plays an important role in insulin homeostasis and glucose metabolism through multiple enzymatic reactions. With increasing data on magnesium deficiency in diabetic patients and epidemiological studies demonstrating magnesium deficiency as a risk factor for diabetes, it is logical to search for its possible beneficial effects on diabetes control and prevention. We aimed to determine whether oral magnesium supplementation improves metabolic control, lipid profile and blood pressure in patients with type II diabetes.

METHODS:
Fifty four patients with type II diabetes were included in a randomized double blind placebocontrolled clinical trial. Patients received either placebo or 300 mg elemental magnesium (as magnesium sulfate -MgSo4-) daily, for 3 months. Metabolic control, lipid profile, blood pressure, magnesium status, hepatic enzymes, hemoglobin concentration, and anthropometric indices were determined in the beginning and at the end of the study.

RESULTS:
Daily administration of 300 mg elemental magnesium for 3 months, significantly improved fasting blood glucose (183.9±15.43 to 125.8±6.52 vs. 196.5±28.12 to 136.5±7.94, p< 0.0001), 2-hour post prandial glucose (239.1±74.75 to 189.1±60mg/dl vs. 246.4±97.37 to 247.8±86.74mg/dl, p< 0.01), lipid profile, blood pressure and hepatic enzymes.

CONCLUSION:
Oral magnesium supplementation with proper dosage has beneficial effects on blood glucose, lipid profile, and blood pressure in patients with type II diabetes.

PMID: 25405132

Attached files

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4810 Diabetes Mg table.jpg admin 02 Jan, 2015 00:15 129.83 Kb 1002
4809 Diabetes and Mg.pdf PDF 2014 admin 02 Jan, 2015 00:14 1.60 Mb 466
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