25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes.
Diabetes Care. 2013 Jan 22.
de Las Heras J, Rajakumar K, Lee S, Bacha F, Holick MF, Arslanian SA.
Division of Pediatric Metabolism, Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain.
OBJECTIVE To 1) determine if plasma 25-hydroxyvitamin D (25[OH]D) concentrations differ among obese youth with normal glucose tolerance (NGT) versus prediabetes versus type 2 diabetes, and 2) assess the relationships between 25(OH)D and in vivo insulin sensitivity and β-cell function in this cohort.
RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations were examined in banked specimens in 9- to 20-year-old obese youth (n = 175; male 42.3%, black 46.3%) (NGT, n = 105; impaired glucose tolerance [IGT], n = 43; type 2 diabetes, n = 27) who had in vivo insulin sensitivity and secretion measured by hyperinsulinemic-euglycemic and hyperglycemic clamp techniques and had an assessment of total body composition and abdominal adiposity.
RESULTS The mean age and BMI of the subjects were 14.3 ± 2.1 years and 35.7 ± 5.6 kg/m(2), respectively. BMI, plasma 25(OH)D, and the proportion of vitamin D-deficient and -insufficient children did not differ across the three groups. Furthermore, there was no association between 25(OH)D and in vivo insulin sensitivity or β-cell function relative to insulin sensitivity (disposition index) in all groups combined or in each group separately.
CONCLUSIONS Our data in obese youth show
- no differences in plasma 25(OH)D concentrations across the glucose tolerance groups, and
- no relationship between 25(OH)D and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in any of the groups.
It remains uncertain if enhancement of the vitamin D status could improve pathophysiological mechanisms of prediabetes and type 2 diabetes in obese youth.
This seems to conflict with previous studies
- African-Americans at high risk of obesity and diabetes - 2011
- Overview Diabetes and vitamin D
- Obesity lowers vitamin D which increases probability of diabetes in children – Nov 2011
- Diabetes 6X more likely for those abdominal obese who have insufficient vitamin D – June 2012
- Diabetes risk reduced 24 percent for every 10 ng increase in vitamin D – Mar 2011
- Vitamin D Deficiency, Obesity and Cardiometabolic Risk: Is there any Relationship - Jan 2010
- Overview Metabolic Syndrome and vitamin D