Serum 25-hydroxyvitamin D, parathyroid hormone, and their association with metabolic syndrome in Chinese.
Endocrine. 2013 Jan 23.
Li LH, Yin XY, Yao CY, Zhu XC, Wu XH.
Department of Internal Medicine, Dali University School of Clinical Medicine, Jiashibo Road 32, Dali, 671000, Yunnan, China, lilihuayncn at gmail.com.
Increasing evidence suggests that 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels are associated with metabolic syndrome (MetS). In 2010, we explored the association of serum 25(OH)D and PTH levels with MetS in 1,390 Chinese participants, aged 20-83 years. Anthropometric phenotypes, blood pressure, and the incidence of MetS were evaluated. In addition, serum lipids, 25(OH)D, and PTH were measured. The median concentration of 25(OH)D and PTH were 55.3 nmol/l and 2.8 pmol/l, respectively. The prevalence of vitamin D deficiency (<50 nmol/l) was 39.9 %, with 34.5 % in men and 47.8 % in women.
After accounting for confounding factors and serum PTH, a 10 nmol/l higher serum 25(OH)D level was associated with a 10 % lower risk of MetS (OR = 0.90, 95 % CI 0.84-0.96, P = 0.0007).
Furthermore, participants with vitamin D sufficiency had a 35 % lower risk of MetS than those with vitamin D deficiency (OR = 0.65, 95 % CI 0.51-0.84, P = 0.0009).
PTH was not associated with the risk of MetS after adjustment for confounding factors. These results were confirmed in both men and women. Thus in this cohort of Chinese individuals, vitamin D deficiency is common and optimal vitamin D level is inversely associated with MetS, independent of several confounders and PTH level. The clinical significance of these findings warrants further study.
- Overview Metabolic Syndrome and vitamin D
- Review of Metabolic Syndrome and vitamin D - June 2012
- Metabolic Syndrome 13 percent more likely for every 10 ng less vitamin D – Meta-analysis Jan 2014
- Metabolic Syndrome 70 percent more likely if vitamin D insufficient - March 2012
- Metabolic syndrome 50 percent more likely if under 20 ng of vitamin D - May 2011
- All items in category Metabolic Syndrome
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
3090 visitors, last modified 27 Dec, 2013,