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More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021

Alternate Dosing Protocol for Magnesium Sulfate in Obese Women With Preeclampsia: A Randomized Controlled Trial

Clinical Trial Obstet Gynecol. 2020 Dec;136(6):1190-1194. doi: 10.1097/AOG.0000000000004137.
Kathleen F Brookfield 1, Kierstyn Tuel, Monica Rincon, Abbie Vinson, Aaron B Caughey, Brendan Carvalho

Objective: To evaluate whether obese women need greater doses of magnesium sulfate to obtain therapeutic serum concentrations for eclamptic seizure prevention.

Methods: Women with preeclampsia and a body mass index (BMI) of 35 or higher were randomly allocated to either the Zuspan regimen of magnesium sulfate (4-g intravenous IV loading dose, then a 1-g/h infusion) or to alternate dosing (6-g IV loading dose, then a 2-g/h infusion). Women had serum magnesium concentrations obtained at baseline, as well as after administration of magnesium sulfate at 1 hour, 4 hours, and delivery. The primary outcome was the proportion of women who had subtherapeutic serum magnesium concentrations (less than 4.8 mg/dL) 4 hours after administration. A sample size of 18 women per group was planned to compare the proportion of women with subtherapeutic serum magnesium concentrations in each group.

Results: From July 12, 2016, to March 14, 2019, 89 women with preeclampsia were screened and 37 were enrolled: 18 to the Zuspan regimen and 19 to the alternate regimen. A significantly greater proportion of women administered the Zuspan regimen had subtherapeutic serum magnesium concentrations at 4 hours (100% [95% CI 59-100] vs 63% [95% CI 41-81]; P=.01) compared with women administered the alternate higher dose regimen. At 4 hours, mean concentrations were significantly higher in the alternate regimen group (3.53 mg/dL±0.3 [Zuspan regimen] vs 4.41±0.5 [alternate regimen]; P<.01).

Conclusion: The alternate dosing regimen of a 6-g IV loading dose followed by a 2-g/h IV maintenance dose more reliably achieves therapeutic serum magnesium concentrations (as defined by a concentration of at least 4.8 mg/dL) in obese women with preeclampsia.

Clinical trial registration: ClinicalTrials.gov, NCT02835339.

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Number of studies in both of the categories of Magnesium and:

Bone 16,  Cardiovascular 17,   Diabetes 28. Depression 14,  Obesity 11,   Omega-3 36,  Zinc 24,  Pregnancy 11,  Headache 11,   Virus 26,   Calcium 27   Virus 26   Mortality 9   Hypertension 12   Inflammation 3   Pain 7 etc.

Overview Magnesium and vitamin D Has a venn diagram of relationship of Mg and Vit D

Magnesium Miracle, 2nd edition - Aug 2017

VitaminDWiki - 11 studies in both categories Obesity and Magnesium

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