Nutr Rev. 2012 Mar;70(3):153-64. doi: 10.1111/j.1753-4887.2011.00465.x. Epub 2012 Feb 15.
Rosanoff A, Weaver CM, Rude RK.
Center for Magnesium Education & Research, 13-1255 Malama Street, Pahoa, HI 96778, USA. ARosanoff at gmail.com
In comparison with calcium, magnesium is an "orphan nutrient" that has been studied considerably less heavily. Low magnesium intakes and blood levels have been associated with type 2 diabetes, metabolic syndrome, elevated C-reactive protein, hypertension, atherosclerotic vascular disease, sudden cardiac death, osteoporosis, migraine headache, asthma, and colon cancer. Almost half (48%) of the US population consumed less than the required amount of magnesium from food in 2005-2006, and the figure was down from 56% in 2001-2002. Surveys conducted over 30 years indicate rising calcium-to-magnesium food-intake ratios among adults and the elderly in the United States, excluding intake from supplements, which favor calcium over magnesium.
The prevalence and incidence of type 2 diabetes in the United States increased sharply between 1994 and 2001
as the ratio of calcium-to-magnesium intake from food rose from <3.0 to >3.0.
Dietary Reference Intakes determined by balance studies may be misleading if subjects have chronic latent magnesium deficiency but are assumed to be healthy. Cellular magnesium deficit, perhaps involving TRPM6/7 channels, elicits calcium-activated inflammatory cascades independent of injury or pathogens. Refining the magnesium requirements and understanding how low magnesium status and rising calcium-to-magnesium ratios influence the incidence of type 2 diabetes, metabolic syndrome, osteoporosis, and other inflammation-related disorders are research priorities.
© 2012 International Life Sciences Institute.
Black bars =Ca/Mg ratio for women
Red lines - % of US who were diabetic
Highlights from PDF
- symptoms of DM2 have been associated with intracellular calcium-to-magnesium ratios,96-98
- The possibility that some portion of the US population, who are assumed to be healthy and fully magnesium replete, in fact have a chronic latent magnesium deficit complicates the true assessment of this population with regard to magnesium[http://www.vitamindwiki.com/dl2206 status.
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(The Strong Link of Low Nutritional Magnesium and High Calcium-to-Magnesium Ratio in the Genesis of Cardiovascular Disease)
by A. Rosanoff, PhD, Director of Research & Science Information Outreach Center for Magnesium Education & Research, Pahoa, HI
PDF is attached at the bottom of this page
Contains a huge number of references and charts about Magnesium and many health problems
- Overview Magnesium and vitamin D
- Hypomagnesemia (low Magnesium) is very prevalent in ICU – 1999
- Magnesium may be an important way to treat brain trauma wonder if decrease brain trauma if have increased Mg or lower Ca/Mg ratio
- Low Magnesium and Heart Attacks – associated for 40 years – Nov 2012
- Correcting magnesium deficiencies may prolong life – Space Station Feb 2012
- Magnesium and Vitamin D - similar, different and synergistic
- Hypothesis: Fluoridation reduces magnesium in body
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Calcium 2X of Magnesium seems good – China Feb 2013
- Supplemental Magnesium for Prevention of Atrial Fibrillation: Role of Diabetes Mellitus Dec 2012 letter, no text