Association between diabetes and subsequent Parkinson disease A record-linkage cohort study
Neurology DOI: https://doi.org/10.1212/WNL.0000000000005771
Eduardo De Pablo-Fernandez, Raph Goldacre, Julia Pakpoor, Alastair J. Noyce, Thomas T. Warner
Looked at hospital admission records for 8 million people over a 12 year time period
- Those admitted to hospital for diabetes aged 25-44 were 3.8 X more likely to later be admitted to hospital for Parkinson’s disease
- VitaminDWiki suspects a much higher rate would have been found if had waited for the young adults to get into the senior age range typical for Parkinson’s disease (25 years instead of 12)
- Reminder - Diabetes lowers the vitamin D level (perhaps due to poor gut ==> poor bioavailability), and lower vitamin D levels increase the chance of Parkinson;s Disease
Due to low Vitamin D?
- Parkinson’s Disease systematic review finds association with low vitamin D – Jan 2016
- Parkinson’s disease 2X more likely if low Vitamin D – meta-analysis May 2014
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
Due to low Omega-3?
- Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017
- Omega-3 might manage T2 Diabetes – March 2018
Due to poor Vitamin D Receptor?
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
Items in both categories Diabetes and Magnesium are listed here:
- Retinopathy in males 6.9 X more likely if low vitamin D and low Magnesium - June 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
Items in both categories Parkinson's and Magnesium are listed here:
Diseases that may be related via low vitamin D contains the following:
- Diabetes ==> Cognitive impairment
- Diabetes ==> Vertebral fracture in men only
- Diabetes ==> Rheumatoid Arthritis
- Diabetes ==> PCOS women
- PCOS ==> Diabetes
- Diabetes ==> Cancers
- Diabetes ==> Pancreatic Cancer
- Diabetes ==> Alzheimer's
- Diabetes (T1) ==> Multiple Sclerosis
- Diabetes ==> TB?
- Diabetes (T1) ==> Multiple Sclerosis
- Diabetes ==> Parkinson's
Objective To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD).
Methods Linked English national Hospital Episode Statistics and mortality data (1999–2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis.
Results A total of 2,017,115 individuals entered the T2DM cohort and 6,173,208 entered the reference cohort. There were significantly elevated rates of PD following T2DM (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.29–1.35; p < 0.001). The relative increase was greater in those with complicated T2DM (HR 1.49, 95% CI 1.42–1.56) and when comparing younger individuals (HR 3.81, 95% CI 2.84–5.11 in age group 25–44 years).
Conclusions We report an increased rate of subsequent PD following T2DM in this large cohort study. These findings may reflect shared genetic predisposition and/or disrupted shared pathogenic pathways with potential clinical and therapeutic implications.
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The word vitamin does not occur once in the Neurology study