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Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018

Association between diabetes and subsequent Parkinson disease A record-linkage cohort study

Neurology DOI: https://doi.org/10.1212/WNL.0000000000005771
Eduardo De Pablo-Fernandez, Raph Goldacre, Julia Pakpoor, Alastair J. Noyce, Thomas T. Warner


Looked at hospital admission records for 8 million people over a 12 year time period

  • Those admitted to hospital for diabetes aged 25-44 were 3.8 X more likely to later be admitted to hospital for Parkinson’s disease
  • VitaminDWiki suspects a much higher rate would have been found if had waited for the young adults to get into the senior age range typical for Parkinson’s disease (25 years instead of 12)
  • Reminder - Diabetes lowers the vitamin D level (perhaps due to poor gut ==> poor bioavailability), and lower vitamin D levels increase the chance of Parkinson;s Disease

Due to low Vitamin D?

Due to low Omega-3?

Due to poor Vitamin D Receptor?

Due to low Magnesium? – the following study is in both the PD and Diabetes categories

Items in both categories Diabetes and Magnesium are listed here:

Objective To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD).

Methods Linked English national Hospital Episode Statistics and mortality data (1999–2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis.

Results A total of 2,017,115 individuals entered the T2DM cohort and 6,173,208 entered the reference cohort. There were significantly elevated rates of PD following T2DM (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.29–1.35; p < 0.001). The relative increase was greater in those with complicated T2DM (HR 1.49, 95% CI 1.42–1.56) and when comparing younger individuals (HR 3.81, 95% CI 2.84–5.11 in age group 25–44 years).

Conclusions We report an increased rate of subsequent PD following T2DM in this large cohort study. These findings may reflect shared genetic predisposition and/or disrupted shared pathogenic pathways with potential clinical and therapeutic implications.

PDF is available free at Sci-Hub   10.1212/WNL.0000000000005771

The word vitamin does not occur once in the Neurology study

Created by admin. Last Modification: Thursday July 19, 2018 15:26:39 UTC by admin. (Version 6)
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