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Drug–Vitamin D Interactions, A Systematic Review – Jan 2013

Nutr Clin Pract January 10, 2013 0884533612467824
Kim Robien, PhD, RD, CSO 1
Sarah J. Oppeneer, MS 2
Julia A. Kelly, MS, MLIS 3
Jill M. Hamilton-Reeves, PhD, RD 4
1 Department of Epidemiology and Biostatistics, George Washington University School of Public Health and Health Services, Washington, DC
2 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis
3 University Libraries, University of Minnesota, Minneapolis
4 University of Kansas Medical Center, School of Health Professions, Department of Dietetics & Nutrition, Kansas City, Kansas
Kim Robien, PhD, RD, CSO, Associate Professor, Department of Epidemiology and Biostatistics, George Washington University School of Public Health and Health Services, 2100-W Pennsylvania Ave NW, 8th Floor, Washington, DC, 20037, USA. Email: krobien at gwu.edu.

Extensive media coverage of the potential health benefits of vitamin D supplementation has translated into substantial increases in supplement sales over recent years. Yet, the potential for drug–vitamin D interactions is rarely considered. This systematic review of the literature was conducted to evaluate the extent to which drugs affect vitamin D status or supplementation alters drug effectiveness or toxicity in humans. Electronic databases were used to identify eligible peer-reviewed studies published through September 1, 2010. Study characteristics and findings were abstracted, and quality was assessed for each study.
A total of 109 unique reports met the inclusion criteria.
The majority of eligible studies were classified as class

  • C (nonrandomized trials, case-control studies, or time series) or
  • D (cross-sectional, trend, case report/series, or before-and-after studies).
      Only 2 class C and 3 class D studies were of positive quality.

Insufficient evidence was available to determine whether

  • lipase inhibitors,
  • antimicrobial agents,
  • antiepileptic drugs,
  • highly active antiretroviral agents, or
  • H2 receptor antagonists
      alter serum 25(OH)D concentrations.


  • Atorvastatin appears to increase 25(OH)D concentrations, whereas
  • concurrent vitamin D supplementation decreases concentrations of atorvastatin.
  • Use of thiazide diuretics in combination with calcium and vitamin D supplements
      may cause hypercalcemia in the elderly or those with compromised renal function or hyperparathyroidism.

Larger studies with stronger study designs are needed to clarify potential drug–vitamin D interactions,
especially for drugs metabolized by cytochrome P450 3A4 (CYP3A4).

Healthcare providers should be aware of the potential for drug–vitamin D interactions.

Partial PDF Table of Contents

 Download the PDF from VitaminDWiki

VitaminDWiki - Interactions with Vitamin D contains

Interactions with Vitamin D has 110 items

Various drugs decrease Vitamin D
Drugs that may harm bone (vitamin D needed) -April 2016
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Drugs which create a vitamin D deficiency
Antibiotics and Vitamin D are associated with many of the same diseases
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Plastics, BPA, PCB and Vitamin D deficiency
Smoking   Coffee
Cooked dried beans or peas

Interaction of drugs with Vitamin D cofactors

Dr. Jockers 2018

Attached files

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10831 Interactions ToC.jpg admin 11 Nov, 2018 19:54 23.29 Kb 725
10830 Intractions.jpg admin 11 Nov, 2018 19:49 70.35 Kb 1101
10829 Drug-vitamin D interactions.pdf admin 11 Nov, 2018 19:45 914.97 Kb 583