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Cadmium liver problem 5 X less likely when vitamin D is greater than 40 ng – April 2018

The association between serum vitamin D levels and renal tubular dysfunction in a general population exposed to cadmium in China.

PLoS One. 2018 Apr 10;13(4):e0195682. doi: 10.1371/journal.pone.0195682. eCollection 2018.
Chen X1,2, Dai Y1, Wang Z2, Zhu G3, Ding X1, Jin T4.

Headache category listing has 40 items which includes the following
Metal MigraineNo Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE Migraine if decrease
Iron0.97 ug0.48 ug2X MORE Migraine if decrease
Lead1.48 ug0.78 ug 2X MORE Migraine if decrease
Magnesium10.6 ug34.5 ug 3.5X LESS Migraine if increase
Zinc0.24 ug 5.77 ug 24X LESS Migraine if increase

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Cadmium exposure can cause renal tubular dysfunction. Recent studies show that vitamin D can play multiple roles in the body. However, the association between serum vitamin D levels and renal tubular dysfunction in a general population exposed to cadmium has not been clarified. We performed study to assess the effects of cadmium on serum 25(OH) D levels and the association between serum 25(OH) D levels and renal tubular dysfunction in a population environmentally exposed to cadmium. A total of 133 subjects living in control area and two cadmium polluted areas were included in the present study. Cadmium in urine (UCd) and blood (BCd), urinary β2Microglobulin (UBMG), urinary retinol binding protein (URBP) and serum 25 (OH) D were determined. Logistic regression was used to estimate the association between 25 (OH) D and prevalence of renal tubular dysfunction. No significant differences were observed in serum 25(OH) D levels among the four quartile of UCd and BCd after adjusting with cofounders.

After adjusted with the confounders, the odds ratio (OR) of subjects with 25(OH) D ≥ 40 ng/ml were 0.20 (95%CI: 0.1-0.8) if UBMG was chosen as indicators of renal dysfunction and 0.28 (95%CI: 0.1-1.1) if URBP was chosen as indicators of renal dysfunction, compared with those with 25(OH) D < 30 ng/ml, respectively. Similar results were observed in those subjects living in cadmium polluted areas or with high level of UCd or BCd. Our data indicated that cadmium exposure did not affect serum 25(OH) D level and high 25 (OH) D levels were associated with a decreased risk of renal tubular dysfunction induced by cadmium.

PMID: 29634781 DOI: 10.1371/journal.pone.0195682

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9689 cadmium.pdf PDF 2018 admin 12 Apr, 2018 12:11 2.23 Mb 475
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