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Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021

Am J Cardiovasc Drugs. 2021 Jul 23. doi: 10.1007/s40256-021-00492-8   PDF costs $50
Qingtao Hou 1, Caishuang Pang 2, Yuqin Chen 3


Statins and Vitamin D - many studies   >25 major entries as of July 2021

If you really must take statins and they cause pain, vitamin D will relieve the pain - 2015
Apparently: Stains ==> less cholesterol ==> less pre-vitamin D ==> less vitamin D from sun

VitaminDWiki pages containing "STATIN" in title

Items found: 25
Title Modified
Statins and Vitamin D - many studies 30 Nov, 2022
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021 23 Jul, 2021
Statin side-effects are reduced by Vitamin D – US patent Application – April 2019 14 Nov, 2019
Statin pain eliminated by 7100 IU vitamin D (50000 IU weekly) – July 2011 21 Jul, 2019
Most Profitable Pill in Medical History Is Based on Flawed Science (Statins) May 2019 02 Jun, 2019
Low-dose statin plaque formation stopped by Omega-3 – RCT Dec 2017 24 Jan, 2018
Statin-induced Myalgias corrected with 100000 weekly Vitamin D2 20 Jul, 2017
Statin use increased probability of diabetes in women by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
Statin use increased probability of diabetes by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
The statin Crestor dramatically increases levels of vitamin D in the blood – Jan 2012 17 May, 2016
Some statins increase skin cancer risk by 40 percent (reducing vitamin D levels) – Jan 2016 10 Jan, 2016
Theories on the interaction between statins and vitamin D – 2012 10 Jan, 2016
If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015 22 May, 2015
One statin decreased vitamin D levels but the other did not – March 2010 14 Apr, 2015
Not all statins increase vitamin D levels – Dec 2010 14 Apr, 2015
Off topic – Hypertension and statin pain reduced by Coenzyme Q10 – 2010 26 Jan, 2015
Statins with low vitamin D increased chance of musculoskeletal pain by 2X – Jan 2015 29 Nov, 2014
Statin pain associated with 10 ng less vitamin D – meta-analysis Oct 2014 24 Oct, 2014
Diabetics have problems with low Magnesium , especially if taking statins – Aug 2013 08 May, 2014
Statin-induced Myalgias corrected with 100000 weekly Vitamin D 04 May, 2014
Off topic: Statins associated with increased cataracts (wonder about low vitamin D) - Sept 2013 29 Sep, 2013
Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013 28 Aug, 2013
Breast cancer 2X more likely if have taken statins for 10 years – July 2013 11 Jul, 2013
Statins associated with 14X increase in Polymyalgia Rheumatica (a new disease) – Aug 2012 09 Nov, 2012

Background: Myopathy is the most widely reported statin-associated adverse event. Several studies have linked vitamin D deficiency with statin-related myopathy.

Objective: This meta-analysis aimed to investigate whether adult patients with statin-related myopathy have a lower 25-hydroxyvitamin D (25OHD) level than patients without myopathy and whether statin-related myopathy in vitamin D-deficient patients can be improved by vitamin D supplementation.

Methods: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched until 28 September 2020. Original studies comparing the 25OHD levels of patients with and without myopathy or detecting the impact of vitamin D supplementation on statin-related muscular intolerance were included. Subgroup analyses based on the sample size and baseline 25OHD level were conducted.

Results: This meta-analysis, based on nine cohort studies with a total of 2906 patients, revealed that the 25OHD level of patients with statin-related myopathy was significantly lower than that of patients without myopathy [weighted mean difference - 4.17 ng/mL; 95% confidence interval (CI) - 7.70 to - 0.63; p = 0.021]. The overall analysis from another four studies with 446 patients who were previously vitamin D deficient and reported statin-related muscular intolerance showed that the pooled tolerance rate of statins improved to 89% (95% CI 8692; p < 0.001) after vitamin D supplementation.

Conclusions: The present meta-analysis provides evidence that low 25OHD level is associated with statin-related myopathy and that exogenous vitamin D supplementation can improve statin-related muscular intolerance associated with low 25OHD level in most cases. Our findings may provide useful insight for the prevention and treatment of statin-related myopathy.


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