Nutr Clin Pract January 10, 2013 0884533612467824
Kim Robien, PhD, RD, CSO 1
Sarah J. Oppeneer, MS 2
Julia A. Kelly, MS, MLIS 3
Jill M. Hamilton-Reeves, PhD, RD 4
1 Department of Epidemiology and Biostatistics, George Washington University School of Public Health and Health Services, Washington, DC
2 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis
3 University Libraries, University of Minnesota, Minneapolis
4 University of Kansas Medical Center, School of Health Professions, Department of Dietetics & Nutrition, Kansas City, Kansas
Kim Robien, PhD, RD, CSO, Associate Professor, Department of Epidemiology and Biostatistics, George Washington University School of Public Health and Health Services, 2100-W Pennsylvania Ave NW, 8th Floor, Washington, DC, 20037, USA. Email: krobien@gwu.edu.
Extensive media coverage of the potential health benefits of vitamin D supplementation has translated into substantial increases in supplement sales over recent years. Yet, the potential for drug–vitamin D interactions is rarely considered. This systematic review of the literature was conducted to evaluate the extent to which drugs affect vitamin D status or supplementation alters drug effectiveness or toxicity in humans. Electronic databases were used to identify eligible peer-reviewed studies published through September 1, 2010. Study characteristics and findings were abstracted, and quality was assessed for each study.
A total of 109 unique reports met the inclusion criteria.
The majority of eligible studies were classified as class
- C (nonrandomized trials, case-control studies, or time series) or
- D (cross-sectional, trend, case report/series, or before-and-after studies).
Only 2 class C and 3 class D studies were of positive quality.
Insufficient evidence was available to determine whether
- lipase inhibitors,
- antimicrobial agents,
- antiepileptic drugs,
- highly active antiretroviral agents, or
- H2 receptor antagonists
alter serum 25(OH)D concentrations.
{However,}
- Atorvastatin appears to increase 25(OH)D concentrations, whereas
- concurrent vitamin D supplementation decreases concentrations of atorvastatin.
- Use of thiazide diuretics in combination with calcium and vitamin D supplements
may cause hypercalcemia in the elderly or those with compromised renal function or hyperparathyroidism.
Larger studies with stronger study designs are needed to clarify potential drug–vitamin D interactions,
especially for drugs metabolized by cytochrome P450 3A4 (CYP3A4).
Healthcare providers should be aware of the potential for drug–vitamin D interactions.
Partial PDF Table of Contents
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VitaminDWiki - Interactions with Vitamin D contains
Interactions with Vitamin D hasVarious drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives, Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Plastics, BPA, PCB and Vitamin D deficiency
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Smoking Coffee
Cooked dried beans or peas
- wiki page:
- Avoiding the Sun is Just as Dangerous as Cigarettes - video March 2024
- Autism risk if toxins, heavy metals, microplastics, etc during pregnancy (unless add Vitamin D) – Feb 2024
- 90% in US have chlormequat chloride in urine – which is linked to reduced fertility – Feb 2024
- Beans etc, can cut in half the response to fat-soluble Vitamin D and K - June 2019
- Fructose, HFCS and Vitamin D - many studies
- Pesticides 8 X less likely to result in female infertility if take vitamin D – Sept 2023
- Fluoride reduces Vitamin D and Magnesium - many studies
- Parkinson's Disease 5X more likely if Trichloroethylene (TCE, wonder about Vit D) - March 2023
- Fluoride lowers IQ in Children (It blocks Vitamin D and Magnesium) - March 2023
- Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Medications that appear to lower Vitamin D – Aug 2021
- Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
- Common drugs as vitamin D disruptors – 2020
- 1.5X more likely to be Vitamin D deficient if drink lots of coffee – Sept 2021
- 24 drugs that typically reduce Vitamin D levels – Review Aug 2021
- Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021
- Endocrine Disrupting Chemicals and Vitamin D (T1 Diabetes in this case) - April 2020
- Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
- PFAS (forever chemicals) reduce Vitamin D and VDR, cause health problems - many studies
- Arsenic in water is associated with lung problems if low vitamin D - 2019
- Graphic warnings on cigarette packages in 118 countries, US FDA trying again – Aug 2019
- Risk of severe ADHD increased 2X if multiple pesticides in urine while pregnant – June 2019
- BPA is a possible cause of obesity epidemic - Dr. Greger June 2019
- Microplastics now causing problems in most life forms - many studies
- Off topic: Plastics and BPA are getting into seafood and your bloodstream – Dr. Greger Spring 2019
- Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019
- Asian men often smoke then die of lung cancer (if you must smoke, take Vitamin D) – meta-analysis March 2019
- Cell tower removed from school after 4 children and 3 teachers got cancer – March 2019
- Low Vitamin D is one of the causes of oxidative stress and aging – March 2019
- Endocrine Disrupting Chemicals - book April 2019
- Cooked dried beans or peas (pulses) reduce uptake of Vitamin D, Vitamin K by the gut by half – several studies
- Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
- Interaction of drugs with Vitamin D, Magnesium, Vitamin B12, Selenium, etc – Dec 2018
- Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
- Enzyme-inducing antiepileptic drugs required 37 percent more IU Vitamin D to achieve 30 nanograms – Nov 2018
- Low Vitamin D is worse for your health than smoking
- Huge increase in prescription medicines (with possible potency with Vitamin D) – 2015
- Some drugs change potency when Vitamin D is increased (increase in a hormone)
- Use of Tenofovir disoproxil fumarate (Hepatitis-B, AIDS) requires more vitamin D – Sept 2018
- Drug-induced bone loss: a major safety concern (Vitamin D can help) – Sept 2018
- Cadmium liver problem 5 X less likely when vitamin D is greater than 40 ng – April 2018
- Lead in breastmilk reduced vitamin D levels in blood by a third (in rats) – Feb 2018
- 4 cups of coffee increases risk of fracture - meta-analysis 2014
- Fluoride caused bone problems in 80 percent of Vitamin D deficient rats – RCT Nov 2017
- Air pollution associated with poor bone density (less vitamin D) – Nov 2017
- Glucocorticoid treatment reduces Vitamin D getting to cells via 3 or 4 genes
- Osteoporosis treatment with denosumab is helped by Vitamin D and Calcium – 2017
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Plastics, BPA, PCB and Vitamin D deficiency
- Increase of plastic compounds (phthalates) in urine during pregnancy associated with decreased Vitamin D – Aug 2017
- ADHD 2 X more likely if Tylenol used a lot during pregnancy (Autism increased too) – Dec 2016
- ADHD 2 X more likely if Tylenol used a lot during pregnancy (Autism increased too) – Dec 2016
- Woman with rare allergy to vitamin D was desensitized in a single day – Dec 2016
- Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
- Tylenol associated with both low vitamin D and Autism
- Drugs that may harm bone (vitamin D needed) -April 2016
- Off Topic: Taking a PPI for GERD increases chance of death from heart disease by 2X– Aug 2015
- More vitamin D needed if person is taking Glucocorticoids – June 2015
- Familial Mediterranean fever – poor response to colchicine if low vitamin D – June 2015
- Breast Cancer aromatase therapy can cause sore tendons if low vitamin D – March 2015
- Some anticonvulsant drugs significantly reduce vitamin D levels – many studies
- Hormonal contraceptives associated with higher vitamin D levels - 2013, 2018
- Carmel used to color some vitamin D gel caps may cause problems in some people
- Hydrochlorothiazide might be a problem when getting lots of vitamin D – March 2014
- Better response to Inflammatory Bowel Disease drug if more than 30 ng of vitamin D – March 2014
- DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014
- Review of vitamin D interaction with drugs – Jan 2014
- Antiretroviral (TDF) is yet another drug which reduces vitamin D levels – Aug 2013
- PCBs increased the chance of being Vitamin D deficient by 3 percent – May 2013
- Interactions with Vitamin D
- Acid Reflux drugs decrease Vitamin D and Magnesium – Jan 2013
- Drugs Deplete Magnesium
- Drug–Vitamin D Interactions, A Systematic Review – Jan 2013
- Rosuvastatin given for renal problem resulted in increased vitamin D levels – RCT Dec 2012
- Antidepressants might increase infertility and pregnancy problems – Nov 2012
- The statin Crestor dramatically increases levels of vitamin D in the blood – Jan 2012
- Extensive review of influence of drugs on vitamin D and Calcium – April 2012
- Statins associated with 14X increase in Polymyalgia Rheumatica (a new disease) – Aug 2012
- Is more medication needed with high level of vitamin D – March 2012
- Overview Rare Allergic reaction to vitamin D
- DDT and other pesticides decrease vitamin D
- Reasons for low response to vitamin D
- For seniors: taking drugs was associated with about 2 ng less vitamin D – Dec 2011
- Vitamin D interactions with drugs – Oct 2011
- Oral steroid users were 2X more likely to have Vitamin D levels less than 10 ng– Sept 2011
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
- May need more immunosuppressants in winter – when have low level of vitamin D – May 2011
- Oral contraceptives may reduce or increase vitamin D
- What are people taking vitamin D for - Feb 2011
- NLM Vitamin D recommendations and interactions – Jan 2011
- Vitamin D and minimum cereal minimized tooth decay – in 1932
- Not all statins increase vitamin D levels – Dec 2010
- Acne - Accutane - vitamin A - vitamin D and suicide - Nov 2010
- Epileptics have problems with conception - Oct 2010
- On-line survey of drug uses and side effects – including vitamin D
- Possible Vitamin D interactions and vicious circles
- Drugs which create a vitamin D deficiency
- Why vitamin D might not help me
- Sarcoidosis (rare) problems when taking vitamin D - many studies
- Side Effects and Warning for vitamin D
- Statins and Vitamin D - many studies
- Chemotherapy might be amplified by vitamin D
- Smoking reduces vitamin D - many studies
- Hypercalcemia overview
- Some people have problems with vitamin D
- Complete Guide to Prescription & Nonprescription Drugs - 2 pages on Vit D
- Vitamin D Shows Potential in Natural Chemotherapy April 2010
Interaction of drugs with Vitamin D cofactors
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