Ren Fail. 2015 Jun 12:1-4. [Epub ahead of print]
Ozer I1, Mete T, Turkeli Sezer O, Kolbasi Ozgen G, Kucuk GO, Kaya C, Kilic Kan E, Duman G, Ozturk Kurt HP.
Department of Nephrology, Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
Familial Mediterranean fever
|Colchicines do not work||colchicines work|
|Number of patients||29||35|
|Vitamin D||9 ng||18 ng|
Note: Many other drugs also work very differently with high levels of vitamin D
- All items in category Interactions with Vitamin D
- Better response to Inflammatory Bowel Disease drug if more than 30 ng of vitamin D – March 2014
- Review of vitamin D interaction with drugs – Jan 2014
- Drug–Vitamin D Interactions, A Systematic Review – Jan 2013
- Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017
Although colchicines are the only effective treatment of familial Mediterranean fever (FMF), resistance to colchicines (CR) which is observed in up to 30% of the patients is still a problem. Clinically, resistance to colchicine is defined as three or more attacks within the last 6 months period while using ≥2 mg/day colchicine. Previous studies have shown decreased vitamin D levels in FMF patients compared with healthy controls. The aim of this study is to evaluate whether vitamin D levels differ between CR and non-CR FMF patients. This study included 64 FMF patients who were being followed in Nephrology Clinic of Samsun Research and Education Hospital for at least 1 year. FMF was diagnosed according to the criteria defined by Livneh et al. Serum 25-hydroxy vitamin D (25-OHD) concentration (ng/mL) was detected in all FMF patients who were not in an acute attack period. From 64 patients 29 were accepted as CR. Mean 25-OHD level was 9.39 ± 1.00 ng/mL in CR patients and 18.48 ± 1.09 ng/mL in colchicine responsive patients (p < 0.001). Plasma vitamin D levels were significantly lower in colchicine resistant patients. Vitamin D deficiency may be a factor in etiopathogenesis of CR. Studies in larger patient samples that particularly evaluate the response to vitamin D replacement in CR FMF patients are needed.
PMID: 26067744Familial Mediterranean fever – poor response to colchicine if low vitamin D – June 2015
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