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4 cups of coffee increases risk of fracture - meta-analysis 2014

It appears that pregnant women and those at risk for fracture should avoid excess coffee

Coffee consumption and risk of fractures: A systematic review and dose–response meta-analysis - June 2014

+"The fracture risk was 14% higher in women and 24% lower in men with the highest level of coffee consumption." +"There was a dose–response relationship between coffee consumption and fracture risk in women." +  Download the PDF from VitaminDWiki

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Impact of beverage consumption, age, and site dependency on dual energy X-ray absorptiometry (DEXA) measurements in perimenopausal women: a prospective study.– 2017

Arch Med Sci. 2017 Aug;13(5):1178-1187. doi: 10.5114/aoms.2017.66033. Epub 2017 Feb 14.
Lo HC1,2,3, Kuo DP1, Chen YL1.

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The aim of this study was to determine the best site for bone mineral density (BMD) measurements based on T-scores, age, and beverage consumption.

In this prospective study, 271 women stratified by age (average age: 61.9 years) underwent dual energy X-ray absorptiometry (DEXA) scanning of their lumbar spine, hips, and forearms. Osteoporosis was defined as a BMD of 2.5 standard deviations or more below the mean peak bone mass based on a reference population of adult women (translated as a T-score ≤ -2.5), as measured by DEXA. Participants were also evaluated regarding alcohol and caffeine consumption by a semiquantitative questionnaire.

A significant discrepancy was observed in the classification of osteoporosis at different locations, with hip and forearm showing the best correlation (Pearson's r = 0.627, p < 0.001). In addition, for participants over 50 years of age, hip and forearm showed the best correlation. Significant correlations were also noted between forearm T-scores and caffeine consumed and, to a lesser extent, the level of alcohol consumption. In the group ≤ 50 years of age, lumbar spine and forearm T-scores were only associated with alcohol consumption. In the group over 50 years of age, hip and forearm T-scores were only associated with caffeine consumption.

Bone mineral density measurements at the hip and forearm correlated with caffeine consumption in elderly Taiwanese women. This is an important finding since age and caffeine consumption are known risk factors for osteoporosis.

PMID: 28883860 PMCID: PMC5575220 DOI: 10.5114/aoms.2017.66033

Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal – 2010

Nutr Metab (Lond). 2010 Feb 22;7:12. doi: 10.1186/1743-7075-7-12.
femur in elderly men and women: a cohort study.
Hallström H1, Melhus H, Glynn A, Lind L, Syvänen AC, Michaëlsson K.

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Drinking coffee has been linked to reduced calcium conservation, but it is less clear whether it leads to sustained bone mineral loss and if individual predisposition for caffeine metabolism might be important in this context. Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, for the first time, genotypes for cytochrome P450 1A2 (CYP1A2) associated with metabolism of caffeine.

Dietary intakes of 359 men and 358 women (aged 72 years), participants of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), were assessed by a 7-day food diary. Two years later, BMD for total proximal femur, femoral neck and trochanteric regions of the proximal femur were measured by Dual-energy X-ray absorptiometry (DXA). Genotypes of CYP1A2 were determined. Adjusted means of BMD for each category of coffee consumption were calculated.

Men consuming 4 cups of coffee or more per day had 4% lower BMD at the proximal femur (p = 0.04) compared with low or non-consumers of coffee. This difference was not observed in women. In high consumers of coffee, those with rapid metabolism of caffeine (C/C genotype) had lower BMD at the femoral neck (p = 0.01) and at the trochanter (p = 0.03) than slow metabolizers (T/T and C/T genotypes). Calcium intake did not modify the relation between coffee and BMD.

High consumption of coffee seems to contribute to a reduction in BMD of the proximal femur in elderly men, but not in women. BMD was lower in high consumers of coffee with rapid metabolism of caffeine, suggesting that rapid metabolizers of caffeine may constitute a risk group for bone loss induced by coffee.

PMID: 20175915 PMCID: PMC2842270 DOI: 10.1186/1743-7075-7-12

Long-term coffee consumption in relation to fracture risk and bone mineral density in women.= 2013

Am J Epidemiol. 2013 Sep 15;178(6):898-909. doi: 10.1093/aje/kwt062. Epub 2013 Jul 23.
Hallström H, Byberg L, Glynn A, Lemming EW, Wolk A, Michaëlsson K.

High consumption of coffee has been suggested to reduce the risk of some late-onset diseases and death but also to contribute to the development of osteoporotic fractures. Results of previous fracture studies have been inconsistent, and a comprehensive study is needed. The longitudinal population-based Swedish Mammography Cohort, including 61,433 women born in 1914-1948, was followed up from 1987 through 2008. Coffee consumption was assessed with repeated food frequency questionnaires. During follow-up, 14,738 women experienced fracture of any type, and 3,871 had a hip fracture. In a subcohort (n = 5,022), bone density was measured and osteoporosis determined (n = 1,012). After multivariable adjustment, there was no evidence of a higher rate of any fracture (hazard ratio per 200 mL coffee = 0.99; 95% confidence interval: 0.98, 1.00) or hip fracture (hazard ratio per 200 mL coffee = 0.97, 95% confidence interval: 0.95, 1.00) with increasing coffee consumption. A high coffee intake (≥4 cups daily) versus a low intake (<1 cup daily) was associated with a 2%-4% lower bone density, depending on site (P < 0.001), but the odds ratio for osteoporosis was only 1.28 (95% confidence interval: 0.88, 1.87). Thus, high coffee consumption was associated with a small reduction in bone density that did not translate into an increased risk of fracture.

PMID: 23880351 DOI: 10.1093/aje/kwt062

Increased Coffee consumptions associated with less osteoporosis in senior Chinese women – 2015

Associations between frequency of coffee consumption and osteoporosis in Chinese postmenopausal women.
Int J Clin Exp Med. 2015 Sep 15;8(9):15958-66. eCollection 2015.
Yang P1, Zhang XZ2, Zhang K2, Tang Z2.

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BACKGROUND: This study was aimed at estimating the associations between coffee intake and osteoporosis (OP) in Chinese postmenopausal women.

METHODS: We conducted a large-scale, community-based, cross-sectional study to investigate the associations by using self-report questionnaire to access frequency of coffee intake. The total of 1817 participants was available to data analysis in this study. Multiple regression models controlling for confounding factors to include frequency of coffee intake variable were performed to investigate the relationships for OP.

RESULTS: Positive correlations between frequency of meat food intake and T-score were reported (β = 0.216, P value < 0.001). Multiple regression analysis indicated that the frequency of meat food intake was significantly associated with OP (P < 0.05 for model 1 and model 2). The postmenopausal women with high frequency of meat food intake had a lower prevalence of OP.

CONCLUSION: The findings indicated that frequency of coffee intake was independently and significantly associated with OP. The prevalence of OP was more frequent in Chinese postmenopausal women not preferring coffee habits.

PMID: 26629099 PMCID: PMC4658988

Caffeine decreases vitamin D receptor protein expression - 2007

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells
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85 citations as of Sept 2021

85 citations as of Sept 2021

  • Long-term Coffee Consumption in Relation to Fracture Risk and Bone Mineral Density in Women - 2013, not much effect PDF online
  • Bone quality associated with daily intake of coffee: a biochemical, radiographic and histometric study - 2010 PDF online
    "coffee/caffeine intake caused serious adverse effects on calcium metabolism in rats"

Three to four cups of coffee a day linked to longer life unless pregnant of possible fracture - 2017

Three to four cups of coffee a day linked to longer life
Three or 4 cups a day confers greatest benefit, except in pregnancy and for women at risk of fracture
Reporting on publication in the British Medical Journal of 200 studies 10.1136/bmj.j5024
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High vs Low amount of Coffee
Note: Coffee has been known to reduce Gout since 1672

Created by admin. Last Modification: Monday September 20, 2021 16:29:19 GMT-0000 by admin. (Version 15)

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ID Name Comment Uploaded Size Downloads
8897 Hi vs low coffee.jpg admin 09 Dec, 2017 02:57 102.00 Kb 524
8896 Coffee consumption and health.pdf PDF 2017 admin 09 Dec, 2017 02:56 1.12 Mb 440
8893 Coffee Fracture F3.jpg admin 08 Dec, 2017 16:59 18.28 Kb 693
8892 Coffee fracture 2014.jpg admin 08 Dec, 2017 16:58 40.79 Kb 600
8891 Lee-2014-Coffee-consumption-and-risk-of-frac.pdf admin 08 Dec, 2017 16:58 1.17 Mb 672
8890 Caffeine decreases vitamin D receptor protein.pdf admin 08 Dec, 2017 16:42 202.20 Kb 608
8884 Coffee 2017.pdf admin 08 Dec, 2017 13:36 136.76 Kb 461
8883 Coffee 2015.pdf admin 08 Dec, 2017 13:36 507.66 Kb 508
8882 Coffee 2010.pdf admin 08 Dec, 2017 13:35 352.99 Kb 545
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