Loading...
 
Toggle Health Problems and D

Iceland and Vitamin D - many studies


Icelanders (like others) with dementia have low levels of vitamin D - April 2020

Lifestyle and 25-hydroxy-vitamin D among community-dwelling old adults with dementia, mild cognitive impairment, or normal cognitive function
Aging Clinical and Experimental Research vol32, pg 2649–2656 https://doi.org/10.1007/s40520-020-01531-1
Hrafnhildur Eymundsdottir, M. Chang, O. G. Geirsdottir, L. S. Gudmundsson, P. V. Jonsson, V. Gudnason, L. Launer, M. K. Jonsdottir & A. Ramel

Image
Background
Several studies have indicated that older adults with cognitive impairment have a poorer lifestyle than their healthy peers including lower 25-hydroxy-vitamin D levels (25OHD).

Aim
To investigate the associations between lifestyle and 25OHD depending on cognitive status among old adults.

Methods
Community-dwelling old adults (65–96 years) participated in this cross-sectional study based on the Age-Gene/Environment-Susceptibility-Reykjavik-Study. The analytical sample included 5162 subjects who were stratified by cognitive status, i.e., dementia (n = 307), mild cognitive impairment (MCI, n = 492), and normal cognitive status (NCS, n = 4363). Lifestyle variables were assessed and 25OHD was measured. The associations between lifestyle and 25OHD were calculated using linear models correcting for potential confounders.

Results
According to linear regression models, 25OHD was significantly lower in older people with dementia (53.8 ± 19.6 nmol/L) than in NCS participants (57.6 ± 17.7 nmol/L). Cod liver oil (7.1–9.2 nmol/L, P < 0.001) and dietary supplements (4.4–11.5 nmol/L, P < 0.001) were associated with higher 25OHD in all three groups. However, physical activity ≥ 3 h/week (2.82 nmol/L, P < 0.001), BMI < 30 kg/m2 (5.2 nmol/L, P < 0.001), non-smoking (4.8 nmol/L, P < 0.001), alcohol consumption (2.7 nmol/L, P < 0.001), and fatty fish consumption ≥ 3x/week (2.6 nmol/L, P < 0.001) were related to higher 25OHD in NCS only, but not in participants with dementia or MCI.

Discussion
Older people living in Iceland with dementia are at higher risk for 25OHD deficiency when compared to healthy individuals. Physical activity reported among participants with dementia, and MCI is low and is not significantly associated with 25OHD.

Conclusions
Lifestyle factors among NCS participants are associated with 25OHD levels. Importantly, healthy lifestyle should be promoted among individuals with MCI and dementia.
 Download the PDF from VitaminDWiki
See in VitaminDwiki Dementia is associated with low vitamin D - many studies


Fewer than 9% of Icelandic ICU patients had more than 30 ng of Vitamin D - June 2016

Severe vitamin D deficiency is common in critically ill patients at a high northern latitude
https://doi.org/10.1111/aas.12748
R. B. Kvaran, M. I. Sigurdsson, S. J. Skarphedinsdottir, G. H. Sigurdsson

Image
Background
Critically ill patients at southern latitudes have been shown to have low vitamin D levels that were associated with prolonged hospital stay. To our knowledge no studies have been conducted on vitamin D status amongst critically ill patients at high northern latitudes. Despite the Icelandic population traditionally taking vitamin D supplements, we hypothesized that the majority of critically ill patients in Reykjavik, Iceland have low vitamin D levels.
Methods
This was a prospective observational study on 122 patients admitted to Landspitali University Hospital intensive care unit. Serum vitamin D (25(OH)D) was measured in all patients on two occasions (first and second day). The prevalence of vitamin D deficiency and its effect on hospital stay was calculated.
Results
Only 9% of patients had vitamin D levels recommended for good health (>75 nmol/l) and 69% were deficient (25(OH)D < 50 nmol/l). The average difference between the first and second vitamin D samples was 2.8 nmol/l. Forty-three percentage of the severely vitamin D deficient stayed in the ICU for more than 4 days compared to 19% of patients with better status (P = 0.196).
Discussion
Vitamin D deficiency is very common in critically ill patients at high northern latitudes and patients with severely deficient vitamin D levels had trend towards longer intensive care unit stay. Furthermore, 43% of the patients had vitamin D levels under 25 nmol/l that is associated with osteomalacia. It appears that a single vitamin D measurement gives a reasonable clue about the vitamin D status in critically ill patients.

 Download the PDF from Sci-Hub via VitaminDWiki


Vitamin-D homeostasis amongst adult Icelandic population - 2004 (19 ng average)

Laeknabladid. 90(1):29-36 [Article in Icelandic] PMID: 16819011
Oervar Gunnarsson 1 , Olafur Skúli Indriðason, Leifur Franzson, Edda Halldórsdóttir, Gunnar Sigurðsson
1 Division of endocrinology and metabolism, Iceland University Hospital, Fossvogi, 108 Reykjavík, Iceland. gunnars at landspitali.is.

Background: The purpose of this study was to examine the effect of vitamin D intake and production in skin on vitamin D homeostasis in adult Icelanders.

Methods: Participants were 30-85 years old, randomly selected from the registry of the Reykjavik area (64 degrees N) and answered a thorough questionnaire on diet and vitamin supplements. Concentrations of 25(OH)-vitamin D [25(OH)D] in peripheral blood were examined based on season during the study period February 2001-January 2003, vitamin D intake and age (age groups 30-45, 50-65, and 70-85 years old). We defined vitamin D deficiency as either [25(OH)D] <25 nmol/l or as [25(OH)D] where the inverse relationship between serum iPTH and [25(OH)D] became statistically significant.

Results: Of 2310 invited, 1630 subjects participated (70,6% participation) but 21 individuals were excluded due to primary hyperparathyroidism. Mean [25(OH)D] was 46.5-/+20 nmol/l but varied by season, age and vitamin D intake, highest in June-July, 52.1-/+19.8 and lowest in February-March, 42.0-/+20.5 (p<0.001). [25(OH)D] was highest in the oldest age group, 50.8-/+19.7, but lowest in the youngest, 42.5-/+20 as was the intake 16.6-/+10 microg/day compared to 9.9-/+9 microg/day in the youngest. The correlation between vitamin D intake and [25(OH)D] was highest for the oldest group, r=0.41, p<0.001 but lowest in the youngest, r=0.24, p<0.001. [25(OH)D] was significantly higher among users of vitamin supplements (45.4-/+19.7) or fish oil (53.0-/+18.4) than among non-users (38.0-/+18.9). Vitamin D insufficiency was seen among 14.5% of those participating according to traditional definition, but 50% were below [25(OH)D] of 45 nmol/l where negative correlation between [25(OH)D] and PTH became statistically significant.

Conclusions: The serum concentration of 25(OH)D at which vitamin D deficiency becomes biochemically significant is higher than traditionally thought. A daily intake of 15-20 microg/day during wintertime would be required to maintain normal homeostasis in Icelandic adults, which is considerably higher than present recommendations of 7-10 microg/day for adults. Further research is needed to define the limit for vitamin-D sufficiency.


Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries

Volume 49, Issue 6 https://doi.org/10.1177/1403494819896878
Suvi T. Itkonen https://orcid.org/0000-0003-1635-8229 suvi.itkonen at helsinki.fi, Rikke Andersen, , Anne K. Björk, Åsa Brugård Konde, Hanna Eneroth, Maijaliisa Erkkola, Kristin Holvik https://orcid.org/0000-0003-3132-2822, Ahmed A. Madar, Haakon E. Meyer, Inge Tetens, Jóhanna E. Torfadóttir, Birna Thórisdóttir, and Christel J.E. Lamberg-Allardt, +10 -10View all authors and affiliations

Image
Aims: Nordic countries share fairly similar food culture and geographical location as well as common nutrition recommendations. The aim of this paper was to review the latest data on vitamin D status and intake and to describe the national supplementation and food fortification policies to achieve adequate vitamin D intake in the Nordic countries.

Methods: The data are based on results derived from a literature search presented in a workshop held in Helsinki in November 2018 and completed by recent studies.

Results: Vitamin D policies and the implementation of the recommendations differ among the Nordic countries. Vitamin D fortification policies can be mandatory or voluntary and widespread, moderate or non-existent. Vitamin D supplementation recommendations differ, ranging from all age groups being advised to take supplements to only infants. In the general adult population of the Nordic countries, vitamin D status and intake are better than in the risk groups that are not consuming vitamin D supplements or foods containing vitamin D. Non-Western immigrant populations in all Nordic countries share the problem of vitamin D insufficiency and deficiency.

Conclusions: Despite the common nutrition recommendations, there are differences between the Nordic countries in the implementation of the recommendations and policies to achieve adequate vitamin D intake and status. There is a need for wider Nordic collaboration studies as well as strategies to improve vitamin D status, especially in risk groups.
 Download the PDF from VitaminDWiki


Vitamin D in northern latitudes: Intake and status in Icelandic children - thesis - 2018

Title: Vitamin D in northern latitudes: Intake and status in Icelandic children
Alternative Title: D-vítamín á norðlægum slóðum: Inntaka og búskapur íslenskra barna.
Author: Þórisdóttir, Birna
Advisor: Ingibjörg Gunnarsdóttir og Bryndís Eva Birgisdóttir
Date: 2018-08
Language: English
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Matvæla- og næringarfræðideild (HÍ)
Faculty of Food Science and Nutrition (UI)
ISBN: 9789935939449
Subject: Infant; Child; Vitamin D; Nutrition policy; Public health; Ungbörn; Börn; D vítamín; Næringarfræði; Næringarstefna; Doktorsritgerðir
URI: https://hdl.handle.net/20.500.11815/919

Background: Adequate nutrition in childhood is essential for growth, development and health. Vitamin D supplement use is recommended in Iceland, starting in infancy. Little information exists on the vitamin D status of Icelandic infants and children. Vitamin D has been suggested to affect the development of sensitization to food allergens and food allergy. Aim: To study adherence to dietary guidelines among 6-year-old children (paper I), their vitamin D intake and vitamin D status at 12 months and 6 years (papers II and III) and compare vitamin D and feeding in infancy between 6-year-old children IgE-sensitized to food allergens and non-sensitized children (paper IV).

Methods: The study population is a nationally representative Icelandic cohort of infants born in 2005, followed up at 6 years of age. Three-day weighed food records were kept at 9 months (n=196), 12 months (n=170) and 6 years (n=162). Total vitamin D intake was calculated from both diet and supplements. Further infant nutrition data was collected by dietary history from birth to 5 months and by monthly 1-day food records at 5-8 and 10-11 months of age. Serum 25-hydroxyvitamin D (25(OH)D) was measured at 12 months (n=76) and 6 years (n=139) and serum-specific IgE-antibodies against food at 6 years (n=144). Cut-off values for vitamin D deficiency, insufficiency, sufficiency and possibly adversely high levels were set at 25(OH)D <30 nmol/L, 30-50 nmol/L, >50 nmol/L and >125 nmol/L, respectively. The cut-off value for sensitization was set at specific IgE ≥0.35 kUA/L.

Results: Adherence to dietary guidelines varied among 6-year-old children but was poor in general. A quarter, or less, of the children followed the guidelines for fruit and vegetables, fish, wholegrain bread and other fiber-rich cereals and vitamin D supplements. The food intake was mirrored in a non-optimal distribution of macronutrients, fiber and salt intake. Vitamin and mineral density of the diet seemed however adequate, except for vitamin D. Supplements (fish liver oil or liquid infant drops during the first months) were the main sources of vitamin D. Total vitamin D intake was higher at 9-12 months than at 6 years (the median intakes were 8.7 μg/d vs. 4.9 μg/d, respectively, p<0.01). The mean±SD concentration of 25(OH)D at 12 months was 98±32 nmol/L, with 92% of infants defined as having sufficient vitamin D status and none deficient. Vitamin D intake at 9-12 months, either from use of vitamin D supplements or consumption of fortified foods in significant amounts (e.g., 200 ml/d of formula), or both, was the main observed determinant for vitamin D status 12 months. Breastfeeding and season were not associated with vitamin D status at 12 months. Taking vitamin D supplements increased the risk of serum 25(OH)D at possibly adversely high levels, observed in a quarter of 12-month-old infants. At 6 years, vitamin D status was lower than in infancy (57±18 nmol/L), 30% of children were insufficient and 6% deficient. Higher total vitamin D intake at 6 years, blood samples collected in summer and higher serum 25(OH)D measured at 12 months, were associated with higher likelihood of vitamin D sufficiency at 6 years. The vitamin D status decreased during autumn in children not using vitamin D supplements. Fourteen 6-year-old children (10%) were sensitized to food allergens. Higher vitamin D intake at 12 months (OR=0.8, 95% CI=0.7-0.99) and vitamin D supplement use at 6 years (OR=0.2, 95% CI=0.1-0.98) were associated with lower risk of sensitization. Introduction of solid foods prior to four months was associated with increased risk of sensitization (OR=4.9, 95% CI=1.4-17). More weight gain and head circumference growth from 0-2 months and higher prevalence of overweight at 6 years was observed among sensitized than non-sensitized children.

Conclusions: The results indicate that a public health effort among Icelandic children is needed to increase adherence to dietary guidelines, including vitamin D supplement use. Healthy Icelandic infants and children receiving the recommended 10 µg/d vitamin D are likely to be vitamin D sufficient. Vitamin D insufficiency and deficiency may however be prevalent among 6-year-old children due to insufficient intake. Monitoring of diet and vitamin D status among Icelandic infants and children is important, looking both at low and high vitamin D levels. Further studies are needed on the associations of vitamin D and diet with food sensitization and allergy.
 Download the PDF from VitaminDWiki
Note: Thesis includes several of the author's publications


Vitamin D levels crash in Icelandic children by age 6 - Feb 2016

Vitamin D Intake and Status in 6-Year-Old Icelandic Children Followed up from Infancy
Nutrients 2016, 8(2), 75; https://doi.org/10.3390/nu8020075
by Birna Thorisdottir 1,*,Ingibjorg Gunnarsdottir 1,Laufey Steingrimsdottir 1,Gestur I. Palsson 2,Bryndis E. Birgisdottir 1 andInga Thorsdottir 1

  • 1 Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland and Landspitali University Hospital, Reykjavik 101, Iceland
  • 2 Children’s Hospital, Landspitali University Hospital, Reykjavik 101, Iceland

5X fewer children with > 30 ng at age 6:
Possible reasons: 1) Only give 400 IU independent of weight; 2) Cease giving Vitamin D after age 1

Image
High serum 25-hydroxyvitamin D (25(OH)D) levels have been observed in infants in Nordic countries, likely due to vitamin D supplement use. Internationally, little is known about tracking vitamin D status from infancy to childhood. Following up 1-year-old infants in our national longitudinal cohort, our aims were to study vitamin D intake and status in healthy 6-year-old Icelandic children (n = 139) and to track vitamin D status from one year of age. At six years, the mean 25(OH)D level was 56.5 nmol/L (SD 17.9) and 64% of children were vitamin D sufficient (25(OH)D ≥ 50 nmol/L). A logistic regression model adjusted for gender and breastfeeding showed that higher total vitamin D intake (Odds ratio (OR) = 1.27, 95% confidence interval (CI) = 1.08–1.49), blood samples collected in summer (OR = 8.88, 95% CI = 1.83–43.23) or autumn (OR = 5.64, 95% CI = 1.16–27.32) compared to winter/spring, and 25(OH)D at age one (OR = 1.02, 95% CI = 1.002–1.04) were independently associated with vitamin D sufficiency at age six. The correlation between 25(OH)D at age one and six was 0.34 (p = 0.003). Our findings suggest that vitamin D status in infancy, current vitamin D intake and season are predictors of vitamin D status in early school age children. Our finding of vitamin D status tracking from infancy to childhood provides motivation for further studies on tracking and its clinical significance.
 Download the PDF from VitaminDWiki


Chronic Pain in Iceland - low sunshine (low vitamin D) or genes - 2010

Whether the weather influences pain: High prevalence of chronic pain in Iceland and Norway: Common genes? Or lack of sunshine and vitamin D?
Scandinavian Journal of Pain https://doi.org/10.1016/j.sjpain.2010.05.030
Harald Breivik, Aus der Zeitschrift
 Download the PDF from Sci-Hub VitaminDWiki


Note: Iceland is one of the potential sites for a very large Vitamin D trial in 2023

Possible large Vitamin D intervention trial: Iceland, Saudi Arabia etc.


Top Icelandic disease concerns (Global Burden of Disease) - 2010

Top Icelandic disease concerns - Global Burden of Disease 2010


172 Vitamin D publications by Icelandic authors as of Jan 2023

European PubMed


Iceland Vitamin D level 18 ng

Details: Age: 30-85
Gender: Men and Women
Vitamin D Levels (nmol/L): 46.1
Number of participants: 944
Steingrimsdottir L et al (2005) Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 294:2336-2341 URL: http://www.ncbi.nlm.nih.gov/pubmed/16278362


Vitamin D intake from cod = ~400 IU daily average

100 IU of vitamin D per ounce of cod
assume 50 kg of cod consumed per year (Icelanders consume 92 kg of fish/year
Daily consumtion of cod = 140 grams/day = 140 grams/day * 1 ounce/30 grams = 4 ounces/day


Omega-3 intake from cod = ~300 mg/day

Cod contains 221 milligrams of omega-3 fatty acids per 100 grams,
Assume 50 kg of cod consumed per year (Icelanders consume 92 kg of fish/year
Omega-3 Reduces risk of Breast Cancer sometimes reduced by a larger amount than by Vitamin D


See also VitaminDWiki


9,630 Iceland and Vitamin D articles in Google Scholar as of Jan 2023

Google Scholar


There have been 575 visits to this page



Attached files

ID Name Comment Uploaded Size Downloads
19043 Chronic Pain Iceland sci-hub.pdf admin 02 Jan, 2023 15:51 204.68 Kb 6
19042 Iceland Children.jpg admin 02 Jan, 2023 15:33 38.69 Kb 67
19041 6-Year-Old Icelandic Children.pdf admin 02 Jan, 2023 15:32 434.01 Kb 13
19040 Iceland dementia.jpg admin 02 Jan, 2023 14:17 62.41 Kb 102
19039 iceland dementia April 2020.pdf PDF 2020 admin 02 Jan, 2023 14:03 338.43 Kb 10
18945 Iceland ICU.jpg admin 07 Dec, 2022 20:55 20.97 Kb 82
18944 Icelandic critically ill sci-hub.pdf admin 07 Dec, 2022 20:54 349.20 Kb 14
18719 Birna_Thesis_Final_CompressPdf.pdf admin 27 Oct, 2022 19:20 1.34 Mb 25
18713 Nordic 2020.jpg admin 27 Oct, 2022 12:58 80.31 Kb 146
18712 Nordic 2020_CompressPdf.pdf admin 27 Oct, 2022 12:58 353.14 Kb 28
18711 Iceland Hospital.jpg admin 27 Oct, 2022 12:32 35.30 Kb 91
18710 Iceland sci-hub.pdf admin 27 Oct, 2022 12:17 349.20 Kb 22