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Blood–brain barrier dysfunction in multiple sclerosis (improved by vitamin D, etc.) – Jan 2024

Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies

Lancet January, 2024DOI:https://doi.org/10.1016/S1474-4422(23)00377-0 PDF behind paywall
Bettina Zierfuss, PhD, Catherine Larochelle, MD PhD, Prof Alexandre Prat, MD PhD

Summary
Established by brain endothelial cells, the blood–brain barrier (BBB) regulates the trafficking of molecules, restricts immune cell entry into the CNS, and has an active role in neurovascular coupling (the regulation of cerebral blood flow to support neuronal activity). In the early stages of multiple sclerosis, around the time of symptom onset, inflammatory BBB damage is accompanied by pathogenic immune cell infiltration into the CNS. In the later stages of multiple sclerosis, dysregulation of neurovascular coupling is associated with grey matter atrophy.
Genetic and environmental factors associated with multiple sclerosis, including

  • dietary habits,
  • the gut microbiome,
  • and vitamin D concentrations,

might contribute directly and indirectly to brain endothelial cell dysfunction. Damage to brain endothelial cells leads to an influx of deleterious molecules into the CNS, accelerating leakage across the BBB. Potential future therapeutic approaches might help to prevent BBB damage (eg, monoclonal antibodies targeting cell adhesion molecules and fibrinogen) and help to repair BBB dysfunction (eg, mesenchymal stromal cells) in people with multiple sclerosis.

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28,000 hits for "blood brain barrier" "vitamin d" in Google Scholar

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C48&q=%22blood+brain+barrier%22+%22vitamin+d%22&btnG=|Google Scholar]

  • Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis- August 2017 https://doi.org/10.1111/cen3.12398 FREE PDF
  • Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications - June 2022 https://doi.org/10.1093/braincomms/fcac171 FREE PDF
    • "In this review, we focus on recent published data describing the biological effects of Vitamin D in animal models of multiple sclerosis on immune cells, blood–brain barrier function, activation of glial cells and its potential neuroprotective effects."
  • The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update - June 2023 https://doi.org/10.3390/nu15132978 FREE PDF
  • Intranasal administration of vitamin D attenuates blood–brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats - Oct 2016 https://doi.org/10.1177/0271678X16671147 FREE PDF
    • Note: VitaminDWiki has been successfully experimenting in inhaing Vitamin D since about 2015

VitaminDWiki – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 14 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

See Brain in VitaminDWiki

See also in VitaminDWiki

VitaminDWiki – Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.


Blood–brain barrier dysfunction in multiple sclerosis (improved by vitamin D, etc.) – Jan 2024        
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