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Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019

Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients

Disease Markers, Volume 2019, 10 pages, https://doi.org/10.1155/2019/3652894
Jarosław Wajda,1 Maciej Świat,2,3 Aleksander J. Owczarek,4 Aniceta Brzozowska,5 Magdalena Olszanecka-Glinianowicz,5 and Jerzy Chudek6,7

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Background. Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS.

Methods. Serum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS. Mortality data was obtained from the local registry office.


  • Only three subjects (1.3%) had an optimal 25-OH-D level (30-80 ng/mL),
  • 25 (10.4%) had a mildly reduced (insufficient) level,
  • 61 (25.4%) had moderate deficiency, and
  • 151 (62.9%) had a severe VD deficiency.

20% subjects had secondary hyperparathyroidism. The serum 25-OH-D level was significantly lower than that in 480 matched subjects ( vs.  ng/mL).
Of all the patients, 79 (32.9%) died during follow-up observation (44.9 months).
The mortality rates (per year) were 4.81 and 1.89 in a group with and without severe VD deficiency, respectively (incidence rate ratio: 2.52; 95% CI: 1.44–4.68). There was no effect of secondary hyperparathyroidism and iFGF23 levels on mortality rates. Age,  ng/mL, and functional status (modified Rankin scale) were significant factors increasing the risk of death in multivariable Cox proportional hazard regression test.

Conclusions. Severe VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status. VD supplementation in IS survivals may be considered due to high prevalence of its deficiency. However, it is uncertain whether it will improve their survival.

VitaminDWiki – Stroke category contains

123 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

Stroke Meta-analysis

Stroke Mortality

Stroke and Intervention:

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Created by admin. Last Modification: Thursday March 21, 2024 11:59:53 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
11890 Stroke caption.jpg admin 02 May, 2019 12.57 Kb 473
11889 Stroke survival.jpg admin 02 May, 2019 38.88 Kb 651
11888 Ischemic Stroke.pdf admin 02 May, 2019 1.61 Mb 596