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Depression is associated with stroke if low vitamin D or winter – Nov 2018

BMC Psychiatry201818:359, https://doi.org/10.1186/s12888-018-1944-z


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% of post-stroke depression

Summertime Wintertime

Most stroke-depression is <40 ng



This study aimed to describe the seasonal variation of depression prevalence among stroke patients at 1 month and to explore whether vitamin D plays a role in the association between seasons and post-stroke depression (PSD).

Data were collected from 402 acute stroke patients. Seasons were stratified by summertime (June to November) and wintertime (December to May) based on vitamin D status. The impact of seasons on PSD was assessed via binary logistic regression, with summertime considered the referent category. The mediating effect was used to evaluate whether vitamin D plays a role in the association between seasons and PSD.

The prevalence of PSD was significantly higher in the wintertime group than in the summertime group (P = 0.003). The serum vitamin D level was lower in wintertime than in summertime (P < 0.001). Lower vitamin D levels were associated with higher HAMD scores (P < 0.001). In the multivariate analysis, patients in the wintertime group had a higher prevalence of PSD compared with those in the summertime group across all binary logistic regression models after adjusting for potential confounders. When serum vitamin D was added to the above model, there was no association between seasons and PSD (P = 0.056). Vitamin D was independently associated with PSD (OR 0.95, 95% CI 0.935–0.966, P < 0.001).

There was a clear seasonal variation in depression prevalence among stroke patients. Vitamin D status plays a critical mediating role in the relationship between season and post-stroke depression.

Created by admin. Last Modification: Saturday November 10, 2018 13:43:12 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
10818 HAMD-2.png admin 10 Nov, 2018 118.66 Kb 2768
10817 HAMD.jpg admin 10 Nov, 2018 31.61 Kb 2072
10816 Stroke depression winter.pdf admin 10 Nov, 2018 620.14 Kb 638