Effect of Vitamin D and calcium supplementation on ischaemic stroke outcome: a randomised controlled open-label trial
International Journal of Clinical Practice , Early View, DOI: 10.1111/ijcp.12866
Anu Gupta, Sudesh Prabhakar, Manish Modi, Sanjay K Bhadada, Mani Kalaivani, Vivek Lal, Dheeraj Khurana
- Overview Stroke and vitamin D
- Ischemic stroke 5 times more likely to recur if very low vitamin D – June 2016
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014 has the following chart
Items in both categories Stroke and Intervention are listed here:
- Stroke patients getting weekly 50,000 IU Vitamin D did better – trial March 2021
- Stroke not prevented by just 2,000 IU of vitamin D plus 840 mg Omega-3 (VITAL) – Feb 2020
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
Background and aims
Vitamin D deficiency is a common problem in stroke survivors. Observational studies have reported an association of low vitamin D levels with greater stroke severity, poststroke mortality and functional disability. Randomised clinical trials are lacking. We sought to assess the effect of calcium and vitamin D supplementation in ischaemic stroke survivors with vitamin D deficiency/insufficiency on disability/mortality outcomes.
In this randomised controlled open-label trial, 73 patients of acute ischaemic stroke were screened for serum 25 hydroxy Vitamin D (25(OH)D) levels. A total of 53 patients with baseline 25(OH)D <75 nmol/L were randomised into two arms. One received vitamin D and calcium supplementation along with usual care (n=25) and the other received usual care alone (n=28). Primary outcome was the proportion of patients achieving a good outcome [modified Rankin Scale score 0–2] at 6 months and all cause mortality at 6 months.
The age (mean±SD) of participants was 60.4±11.3 years, 69.8% were males. The proportion of patients achieving good outcome was higher in the intervention arm (Adjusted OR 1.9, 95% CI 0.6–6.4; P=.31). The survival probability was greater in the intervention arm (83.8%, CI 62.4–93.6) as compared with the control arm (59.5%, CI 38.8–75.2; P=.049) with adjusted Hazard ratio (HR) of 0.26 (95% CI 0.08–0.9; P=.03).
This is the first randomised controlled study assessing the effect of vitamin D and calcium supplementation on ischaemic stroke outcomes and points towards a potential benefit. Findings need to be validated by a larger trial.
Download the PDF from sci-hub via VitaminDWiki
- The intervention group received a single intramuscular injection of 600 000 IU cholecalciferol followed by oral cholecalciferol 60 000 IU once a month with one gram elemental calcium daily along with usual poststroke care.
- Death rate
16% if supplemented
39% in the usual care arm.
- Survival probability at 6 months
84% if supplemented
60% in usual care arm