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Ischemic stroke 17 X more likely if low vitamin D – April 2017

Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.

Metab Brain Dis. 2017 Apr;32(2):493-502. doi: 10.1007/s11011-016-9939-2. Epub 2016 Dec 14.
Alfieri DF1, Lehmann MF2, Oliveira SR1, Flauzino T1, Delongui F1, de Araújo MC3, Dichi I4, Delfino VD4, Mezzaroba L5, Simão AN5, Reiche EM6.

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Modified Rankin Scale (mRS) three-months later


The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS ≥ 30.0 ng/mL), insufficient (VDI 20.0-29.9 ng/mL), and deficient (VDD < 20.0 ng/mL) status.

Patients had lower levels of 25(OH)D, higher frequency of VDD (43.45% vs. 5.08%, OR: 16.64, 95% CI: 5.66-42.92, p < 0.001), and higher inflammatory markers than controls (p < 0.05).

Patients with VDD showed increased high sensitivity C-reactive protein (hsCRP) levels than those with VDS status (p = 0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p = 0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r = -0.239, p = 0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.

PMID: 27975188 DOI: 10.1007/s11011-016-9939-2

Created by admin. Last Modification: Thursday May 2, 2019 10:19:21 GMT-0000 by admin. (Version 4)

Attached files

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9175 Poor mRs.jpg admin 13 Jan, 2018 14:55 17.81 Kb 449
9174 Stroke 17X.pdf PDF 2017 admin 13 Jan, 2018 14:54 592.79 Kb 492