Loading...
 
Translate Register Log In Login with facebookLogin and Register

Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018

Vitamin D status and its association with season, depression in stroke.

Neurosci Lett. 2018 Sep 24. pii: S0304-3940(18)30650-5. doi: 10.1016/j.neulet.2018.09.046. [Epub ahead of print]
Gu Y1, Zhu Z2, Luan X2, He J3.

  • 1 Department of Psychiatry, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
  • 2 Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
  • 3 Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. hjc at wmu.edu.cn.
VitaminDWiki

Items in both categories Stroke and Depression are listed here:

Items in both categories Stroke and Injection are listed here:


BACKGROUND:
Vitamin D plays a key role in depression. In this study, we aimed to assess the prevalence of vitamin D deficiency or insufficiency and the association between vitamin D status and depression in patients with acute stroke.

METHODS:
From September 2013 to May 2015, consecutive patients with acute stroke were enrolled in this study within 7 days of symptom onset. Clinical information was collected during admission, and stroke severity was assessed at discharge. Depressive symptoms were measured by the 17-item Hamilton Rating Scale for Depression at 1 month after stroke. Based on the depressive symptoms, diagnoses of depression were made in accordance with DSM-IV criteria. Serum vitamin D levels were measured at admission. Binary logistic regression models were used to determine the association between depression and vitamin D levels treated as either absolute values (categorized as deficiency, insufficiency and sufficiency) or month-specific tertiles. Vitamin D levels were categorized by month-specific tertiles (high, intermediate, low) to reflect seasonal variation of serum vitamin D levels.

RESULTS:
A total of 442 patients were enrolled in this study. The prevalence of vitamin D deficiency (< 30 nmol/L) or insufficiency (30-49.99 nmol/L) was 46%. The prevalence of vitamin D deficiency was significantly different in winter compared to summer months (p < 0.001). One hundred seven patients (26.6%) were diagnosed with depression at 1 month. In multivariable analyses, after fully adjusting for other potential confounders, the prevalence of depression was significantly higher in patients in the low tertile (odds ratio(OR) 2.24, 95% confidence interval (CI)1.18 to 4.26; p = 0.014) compared to the high tertile, and the prevalence of depression was also significantly higher in patients with vitamin D deficiency (OR 2.66, 95% CI 1.48 to 4.77; p = 0.001) and insufficiency (OR 1.93, 95% CI 1.00 to 3.74; p = 0.049) compared to those with vitamin D sufficiency.

CONCLUSIONS:
Vitamin D deficiency and insufficiency occur at high rates in acute stroke patients. Low serum vitamin D levels were associated with depression in patients with acute stroke as analyzed by both the absolute level of vitamin D and month-specific tertiles. Intervention studies are needed to determine the benefits of vitamin D supplementation for depression in poststroke patients.

Created by admin. Last Modification: Friday September 28, 2018 10:40:13 GMT-0000 by admin. (Version 3)
See any problem with this page? Report it (FINALLY WORKS)