- Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation
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12 studies in both categories Pregnancy and Bone - VitaminDWiki - Pregnancy category contains
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17 studies in both categories Pregnancy and non-daily Vitamin D
Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation
Nutrients 2024, 16(3), 405; https://doi.org/10.3390/nu16030405
by Min Kim 1,2ORCID,Pia E. Nørrisgaard 1ORCID,Nilo Vahman 1,Olivier N. F. Cexus 2ORCID,Paul A. Townsend 2ORCID,Jakob Stokholm 1,3,Klaus Bønnelykke 1,Bo Chawes 1ORCID and Nicklas Brustad 1,*ORCID
1 COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, U. of Copenhagen, 2820 Copenhagen, Denmark
2 Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK
3 Department of Food Science, University of Copenhagen, 1958 Copenhagen, DenmarkWe previously demonstrated a beneficial effect of high-dose vitamin D in pregnancy on offspring bone and dental health. Here, we investigated the effect of maternal dietary patterns during pregnancy on the risk of bone fractures, bone mineralization and enamel defects until age 6 years in the offspring. Further, the influence of diet on the effect of high-dose vitamin D was analyzed in the COPSAC2010 mother–child cohort including 623 mother–child pairs. A weighted network analysis on FFQs revealed three specific maternal dietary patterns that associated (Bonferroni p < 0.05) with both offspring bone and dental health. The effect of prenatal high-dose (2800 IU/day) vs. standard-dose (400 IU/day) vitamin D on offspring bone mineral content (adjusted mean difference (aMD): 33.29 g, 95% CI: 14.48–52.09, p < 0.001), bone mineral density (aMD: 0.02 g/cm2 (0.01–0.04), p < 0.001), fracture risk (adjusted incidence rate ratio: 0.36 (0.16–0.84), p = 0.02), and enamel defects in primary (adjusted odds ratio (aOR): 0.13 (0.03–0.58), p < 0.01) and permanent molars (aOR: 0.25; (0.10–0.63), p < 0.01) was most pronounced when mothers had lower intake of fruit, vegetables, meat, eggs, sweets, whole grain, offal and fish. This study suggests that prenatal dietary patterns influence offspring bone and dental development and should be considered in order to obtain the full benefits of vitamin D to enhance personalized supplementation strategy.
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12 studies in both categories Pregnancy and Bone This list is automatically updated
- Bone resorption during pregnancy reduced by weekly 28,000 IU of Vitamin D – March 2024
- 2800 IU of Vitamin D in late pregnancy resulted in 3X fewer fractures, 4X fewer enamel defects in offspring – RCT Jan 2024
- Fetal bones helped a bit by 1,000 IU of vitamin D – RCT Feb 2019
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Vitamin D, Calcium and protein very important to bone health – Sept 2015
- Breast Feeding increased risk of low bone density by 24 percent – Sept 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Bone changes during and after pregnancy – April 2012
- Wonder when the first doctor will be found liable for not providing vitamin D to a patient
- Less child bone if mother lacked vitamin D – Dec 2010
- Less bone mass at age 9 if low vitamin D during pregnancy and childhood – Lancet 2006
- Pre-Birth Vitamin D Levels Determine Your Health for Life
VitaminDWiki - Pregnancy category contains
901 items in Pregnancy category - see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin
28 ; Depression 21 ; Diabetes 44 ; Obesity 16 ; Hypertension 44 ; Breathing 35 ; Omega-3 40 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
838 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- Fertility problem (PCOS) reduced by vitamin D: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
- Fertility and Sperm category listing has
140 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
VitaminDWiki – Healthy pregnancies need lots of vitamin D contains
ProblemVit. D
ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
RCTs giving 6,400 IU daily for 38 weeks of pregnancy have proven vastly more than just bone benefits
82 studies in both categories Pregnancy and Infant-Child This list is automatically updated
- Atopic Dermatitus more likely if e-cigarette, passive smoke while pregnant or Caesarean
- 2X less risk of respiratory distress syndrome if 50,000 IU of Vitamin D just before premature birth – RCT May 2024
- 22% of children (0-5y) are stunted, Vitamin D deficiency is a primary cause – several studies
- 2800 IU of Vitamin D in late pregnancy resulted in 3X fewer fractures, 4X fewer enamel defects in offspring – RCT Jan 2024
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023
- Phototherapy to reduce infant Jaundice decreases Vitamin D, Mg, etc. Nov 2022
- Need at least 6,000 IU daily while breastfeeding to eliminate Vitamin D deficiency – meta-analysis Oct 2021
- 6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020
- Seafood (Omega-3) during pregnancy increased childhood IQ by 8 points – review Dec 2019
- Infant 7.6 X more likely to be Vitamin D deficient if mother had been – Nov 2019
- Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019
- Half as many tooth enamel defects in child if 2400 IU Vitamin D in late pregnancy – RCT Aug 2019
- Dr. Sears podcast with Carole Baggerly about Vitamin D (with transcript) - July 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- More UV during first trimester, less Osteoporosis in offspring – June 2019
- Infant Problem-Solving Skills Linked to Mother’s DHA Omega-3 Level During Pregnancy – April 2019
- Vitamin D congress on pregnancy and childhood diseases – April 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Pregnant while black increases chance of death – mothers 3X, infants 2X (low Vitamin D) – Feb 2019
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017
- Medicaid pays medical bills of 40 percent of children and 46 percent of pregnancies - Aug 2018
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- Vitamin D needed by pregnant women and neonates (in developing countries now too - 2 tables) – May 2018
- Higher vitamin D levels during pregnancy resulted in less obese infants – March 2018
- 60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018
- Extreme preterm infants helped somewhat by 800 IU of vitamin D – RCT Jan 2018
- Cerebral Palsy and Vitamin D - many studies
- Vitamin D - Effects on Human Reproduction, Pregnancy, and Fetal Well-being – Dec 2017
- Preterm birth rate increased 60 percent in 50 years (US)
- Born too soon – premature births report by W.H.O. – 2010
- Less bad gut bacteria in infant if even tiny amount of vitamin D during pregnancy – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Child 49 percent higher risk of being overweight if preeclampsia during pregnancy – Sept 2017
- Poor motor development in infant was 40 percent more likely if low maternal vitamin D – July 2017
- Low Vitamin D results in adverse pregnancy and birth outcomes – Wagner meta-analysis March 2017
- Low Vitamin D during pregnancy or as infant causes health problems decades later – Jan 2016
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- All infants with small heads (less than 33 cm) were from mothers with low vitamin D levels – Sept 2015
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Vitamin D and pregnancy – review Nov 2015
- Vitamin D before, during, and after pregnancy - Sept 2012
- Vitamin D levels in moms and infants are low and sometimes very low – Sept 2015
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Leading cause of death age 0-5 – vitamin D deficiency
- Vitamin D levels of breastfeeding mothers and infants in 3 cities – Feb 2015
- Overweight children associated with low vitamin D during pregnancy – 2015, 2018
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
VitaminDWiki -
17 studies in both categories Pregnancy and non-daily Vitamin D This list is automatically updated
- Weekly Vitamin D to mother after birth much better than daily - RCT Aug 2018
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 300,000 IU of Vitamin D is not enough during pregnancy – RCT May 2018
- Monthly 120,000 IU Vitamin D plus daily Calcium was great during pregnancies – RCT Sept 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- 50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Pregnancy – adding 35,000 IU Vitamin D weekly was nice, but not enough – RCT April 2016
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- 50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
- Prenatal Vitamin D (35,000 weekly, 3rd trimester) resulted in 1 cm taller infants at age 1 year – RCT Aug 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013
- 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT March 2013
2800 IU of Vitamin D in late pregnancy resulted in 3X fewer fractures, 4X fewer enamel defects in offspring – RCT Jan 2024Printer Friendly Follow this page for updates609 visitors, last modified 12 Feb, 2024, This page is in the following categories (# of items in each category) - All items in category Infant/Child