Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women.
J Steroid Biochem Mol Biol. 2016 Apr;158:76-81. doi: 10.1016/j.jsbmb.2016.01.007. Epub 2016 Jan 16.
Dimitris MC1, Perumal N2, Craig-Barnes HA3, Leadley M3, Mahmud AA4, Baqui AH5, Roth DE6.
1Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
2Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, Canada.
3Analytical Facility for Bioactive Molecules, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada.
4Centre for Child and Adolescent Health, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.
5Centre for Child and Adolescent Health, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh; International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, USA.
6Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada; Department of Paediatrics, University of Toronto and Hospital for Sick Children, 686 Bay Street, Toronto, ON, Canada. Electronic address: daniel.roth at sickkids.ca.
Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for =8 consecutive weeks and for whom serum samples were available for D3 analysis (n=65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose administration (152.09nmol/L, SD 25.11nmol/L) and remained significantly higher in VitD vs. Pl at 7 days (29.59nmol/L vs. 1.92nmol/L, p=0.007).
Daily average of the group mean D3 during the week following dosing was 66.97nmol/L in VitD versus 2.13nmol/L in Pl.
In conclusion, serum D3 remained significantly elevated throughout the week following =8 consecutive weekly doses of 35,000 IU D3 in pregnant women. However, the clinically significant minimum threshold of serum D3 remains to be established.
Copyright © 2016 Elsevier Ltd. All rights reserved.
KEYWORDS:Bangladesh; Cholecalciferol; Pharmacokinetics; Pregnancy; Vitamin D
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Vitamin D level after 8 weeks was 130 nmol = nanograms
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