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Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019

Association between vitamin D status in early pregnancy and atopy in offspring in a vitamin D deplete cohort

Irish Journal of Medical Science (1971 -) https://doi.org/10.1007/s11845-019-02078-5
Maeve Smith Eileen C. O’Brien Goiuri Alberdi Aisling A. Geraghty Mark Kilbane Malachi J. McKenna Fionnuala M. McAuliff

VitaminDWiki

Lots of development by the 11th week of pregnancy
Fetal Development
Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


Post-birth vitamin D reduces allergies

 Download the PDF from Sci-Hub via VitaminDWiki

Image

Background
Vitamin D status may play a role in the development of atopic diseases due to its action on lung development and immune system development and function.

Aims
Our objective was to assess whether 25-hydroxyvitamin D (25OHD) levels in maternal blood in pregnancy were associated with atopy in children.

Methods
We analysed 279 mother-child pairs from the ROLO study conducted in Dublin, Ireland. Serum 25OHD was measured at 13 and 28 weeks of pregnancy. Development of childhood atopy was self-reported by mothers at follow-up appointments at 6 months, 2 years or 5 years. Logistic regression analysis was used to evaluate associations between maternal 25OHD status and development of atopy.

Results
The mean (SD) 25OHD levels in early and late pregnancy were 41.9 (19.2) nmol/L and 40.2 (21.6) nmol/L, respectively. Maternal 25OHD status in early pregnancy, but not in late pregnancy, was associated with a reduced risk of atopy at 2 years (OR 0.972, CI 0.946–0.999).

In early pregnancy, those with serum 25OHD levels < 30 nmol/L compared with those with 25OHD > 50 nmol/L had significantly greater risk of developing atopy at 2 years (OR 4.76, CI 1.38–16.47).

Conclusions
The development of childhood atopy may be associated with maternal vitamin D deficiency in early pregnancy among a cohort of women at risk of vitamin D deficiency. Further research is required to explore the relationship between vitamin D and atopy, particularly among women with poor vitamin D status, and whether supplementation should be prioritised in early pregnancy to reduce childhood atopy.

Created by admin. Last Modification: Sunday January 12, 2020 19:29:45 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
12561 Atopy 2 years.jpg admin 30 Aug, 2019 02:31 36.70 Kb 56
12560 Atopy.pdf PDF 2019 admin 30 Aug, 2019 02:31 276.75 Kb 33
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