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2800 IU of Vitamin D in late pregnancy resulted in 3X fewer fractures, 4X fewer enamel defects in offspring – RCT Jan 2024


Maternal Diet Associates with Offspring Bone Mineralization, Fracture Risk and Enamel Defects in Childhood and Influences the Prenatal Effect of High-Dose Vitamin D Supplementation

Nutrients 2024, 16(3), 405; https://doi.org/10.3390/nu16030405
by Min Kim 1,2ORCID,Pia E. Nørrisgaard 1ORCID,Nilo Vahman 1,Olivier N. F. Cexus 2ORCID,Paul A. Townsend 2ORCID,Jakob Stokholm 1,3,Klaus Bønnelykke 1,Bo Chawes 1ORCID and Nicklas Brustad 1,*ORCID
1 COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, U. of Copenhagen, 2820 Copenhagen, Denmark
2 Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK
3 Department of Food Science, University of Copenhagen, 1958 Copenhagen, Denmark

We previously demonstrated a beneficial effect of high-dose vitamin D in pregnancy on offspring bone and dental health. Here, we investigated the effect of maternal dietary patterns during pregnancy on the risk of bone fractures, bone mineralization and enamel defects until age 6 years in the offspring. Further, the influence of diet on the effect of high-dose vitamin D was analyzed in the COPSAC2010 mother–child cohort including 623 mother–child pairs. A weighted network analysis on FFQs revealed three specific maternal dietary patterns that associated (Bonferroni p < 0.05) with both offspring bone and dental health. The effect of prenatal high-dose (2800 IU/day) vs. standard-dose (400 IU/day) vitamin D on offspring bone mineral content (adjusted mean difference (aMD): 33.29 g, 95% CI: 14.48–52.09, p < 0.001), bone mineral density (aMD: 0.02 g/cm2 (0.01–0.04), p < 0.001), fracture risk (adjusted incidence rate ratio: 0.36 (0.16–0.84), p = 0.02), and enamel defects in primary (adjusted odds ratio (aOR): 0.13 (0.03–0.58), p < 0.01) and permanent molars (aOR: 0.25; (0.10–0.63), p < 0.01) was most pronounced when mothers had lower intake of fruit, vegetables, meat, eggs, sweets, whole grain, offal and fish. This study suggests that prenatal dietary patterns influence offspring bone and dental development and should be considered in order to obtain the full benefits of vitamin D to enhance personalized supplementation strategy.
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VitaminDWiki - 12 studies in both categories Pregnancy and Bone

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VitaminDWiki - Pregnancy category contains

897 items in Pregnancy category

 - see also


VitaminDWiki – Healthy pregnancies need lots of vitamin D contains

Problem
Vit. D
Reduces
Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


RCTs giving 6,400 IU daily for 38 weeks of pregnancy have proven vastly more than just bone benefits
82 studies in both categories Pregnancy and Infant-Child

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VitaminDWiki - 17 studies in both categories Pregnancy and non-daily Vitamin D

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Attached files

ID Name Comment Uploaded Size Downloads
20796 2800 IU_CompressPdf.pdf admin 12 Feb, 2024 883.79 Kb 22