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Vitamin K2-7 helps bone, blood vessels, cancer, diabetes, etc. – June 2022

Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities

Front Pharmacol. 2022 Jun 14;13:896920. doi: 10.3389/fphar.2022.896920
Nikita Jadhav 1, Saiprasad Ajgaonkar 1, Praful Saha 1, Pranay Gurav 1, Amitkumar Pandey 1, Vivek Basudkar 1, Yash Gada 1, Sangita Panda 1, Shashank Jadhav 2, Dilip Mehta 2, Sujit Nair 1

PDF Table of Contents


Chart: Bone and blood

Vitamin K2-7, also known as menaquinone-7 (MK-7) is a form of vitamin K that has health-beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer's disease, diabetes and peripheral neuropathy. Compared to vitamin K1 (phylloquinone), K2-7 is absorbed more readily and is more bioavailable. Clinical studies have unequivocally demonstrated the utility of vitamin K2-7 supplementation in ameliorating peripheral neuropathy, reducing bone fracture risk and improving cardiovascular health. We examine how undercarboxylated osteocalcin (ucOC) and matrix Gla protein (ucMGP) are converted to carboxylated forms (cOC and cMGP respectively) by K2-7 acting as a cofactor, thus facilitating the deposition of calcium in bones and preventing vascular calcification. K2-7 is beneficial in managing bone loss because it upregulates osteoprotegerin which is a decoy receptor for RANK ligand (RANKL) thus inhibiting bone resorption.
We also review the evidence for the health-beneficial outcomes of K2-7 in diabetes, peripheral neuropathy and Alzheimer's disease. In addition, we discuss the K2-7-mediated suppression of growth in cancer cells via cell-cycle arrest, autophagy and apoptosis. The mechanistic basis for the disease-modulating effects of K2-7 is mediated through various signal transduction pathways such as PI3K/AKT, MAP Kinase, JAK/STAT, NF-κB, etc. Interestingly, K2-7 is also responsible for suppression of proinflammatory mediators such as IL-1α, IL-1β and TNF-α. We elucidate various genes modulated by K2-7 as well as the clinical pharmacometrics of vitamin K2-7 including K2-7-mediated pharmacokinetics/pharmacodynamics (PK/PD). Further, we discuss the current status of clinical trials on K2-7 that shed light on dosing strategies for maximum health benefits. Taken together, this is a synthetic review that delineates the health-beneficial effects of K2-7 in a clinical setting, highlights the molecular basis for these effects, elucidates the clinical pharmacokinetics of K2-7, and underscores the need for K2-7 supplementation in the global diet.
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VitaminDWiki - Overview Vitamin K and Vitamin D contains

Vitamin K2 is similar to D3 in many ways

  1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
  2. Both vitamins appear to influence health in large number of ways
  3. Both vitamins in the body are about 1/10 that of a century ago
    Example: Grass-fed beef has a lot more K2, D3, and Magnesium
  4. Need very little of both vitamins: <1 milligram daily
  5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
  6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
    One of the reasons: No simple blood test for K2 as of Jan 2020

VitaminDWiki - 28 studies in both categories Vitamin K and Bone

This list is automatically updated

VitaminDWiki - 26 studies in both categories Vitamin K and Cardiovascular

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VitaminDWiki - 5 studies in both categories Vitamin K and Diabetes

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VitaminDWiki Vitamin K pages with CANCER in title (7 as of July 2022)

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Items found: 8

VitaminDWiki Vitamin K pages with -7 in title (6 as of July 2022)

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Items found: 9

Created by admin. Last Modification: Friday July 1, 2022 19:23:32 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
18020 K2-7 - bone and blood.jpg admin 01 Jul, 2022 18:19 122.80 Kb 1045
18019 ToC K2-7.jpg admin 01 Jul, 2022 18:19 26.86 Kb 811
18018 Roles for Vitamin K2-7_CompressPdf.pdf PDF 2022 admin 01 Jul, 2022 18:19 1.01 Mb 123