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Bone quality improved 2X by Vitamin D plus Vitamin K2 (trend) – meta-analysis March 2020

The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials

Food and Nutrition March 2020 https://doi.org/10.1039/C9FO03063H
Xiaotong Kuang, Chunxiao Liu, Xiao-fei Guo, Kelei Li, Qingxue Deng and Duo Li


Items in both categories Vitamin K and Bone are listed here:

Overview Vitamin K and Vitamin D contains the following summary

Vitamin K2 is similar to D3 in many ways

  1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
  2. Both vitamins appear to influence health in large number of ways
  3. Both vitamins in the body are about 1/10 that of a century ago
    Example: Grass-fed beef has a lot more K2, D3, and Magnesium
  4. Need very little of both vitamins: <1 milligram daily
  5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
  6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
    One of the reasons: No simple blood test for K2 as of Jan 2020

 Download the PDF from Sci-Hub VitaminDWiki

Background Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality.

Method and Findings A comprehensive search on Web of Science, PubMed, Embase and Cochrane Library (from 1950 to February 2020) and bibliographies of relevant articles was undertaken, with eight randomized controlled trials (RCTs) with a total of 971 subjects included in the meta-analysis. Vitamin K combined with D significantly increased the total bone mineral density (BMD): the pooled effect size was 0.316 [95% CI (confidence interval) 0.031 to 0.601]. A significant decrease of undercarboxylated osteocalcin (-0.945, -1.113 to -0.778) can be witnessed with the combination of vitamin K and D. Simultaneously, subgroup analysis showed that K2 or vitamin K (not specified) supplement was less than 500 µg/d, which combined with vitamin D can significantly increase the total BMD compared with control group on normal diet or the group with no treatment (0.479, 0.101 to 0.858 and 0.570, 0.196 to 0.945).

Conclusions The combination of vitamin K and D can significantly increase total BMD and significantly decrease undercarboxylated osteocalcin, and a more favorable effect is expected when vitamin K2 is used.

Created by admin. Last Modification: Tuesday May 12, 2020 13:02:13 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
13804 Bone K2 sci-Hub.pdf PDF 2020 admin 12 May, 2020 12:58 1.63 Mb 304
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