Vitamin D and K signaling pathways in hepatocellular carcinoma
Gene, Available online 29 July 2017, https://doi.org/10.1016/j.gene.2017.07.074
- Liver cancer half as likely if high level of vitamin D – Feb 2014
- Loading dose greatly improves subsequent daily Vitamin D if have liver fibrosis – RCT Nov 2016
- Important interactions between the liver and vitamin D – May 2013
- Cirrhosis in hospital 2.9 X less likely to get need ICU when supplemented with Vitamin K – Nov 2015
- Alcoholic liver disease 8X more likely among alcoholics if very low vitamin D – May 2015
- Liver cancer nicely treated by high dose vitamin D for 16 weeks (early stage, in rats) – April 2018
Overview Liver and vitamin D contains the following summary
- Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
- Fact: Liver diseases often result in lower levels of vitamin D
- Fact: Various pain relievers damage the liver function
- Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
- Options with a poorly functioning liver appear to be:
- Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
- Increase the response you get from vitamin D
- Increase sunshine / UVB,
- Get the response you get from the sun/UVB
- Consider supplementing with Iron - a patented Iron supplement appears to work very well
- Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
- Get Calcidiol which does not need the liver
- Use Topical Vitamin D - activation by the skin etc does not require the liver
Click on image for ways of getting vitamin D even if Liver is not functioning well
Manal L. Loukaa, Ahmed M. Fawzyb, Abdelrahman M. Naiemb, Mustafa F. Elseknedyb, Ahmed E. Abdelhalimb, Mohamed A. Abdelghanyb
• Early diagnosis of HCC with prompt treatment increases the opportunity of patients to survive.
• Vitamins are important for the control of various cancers.
• Vitamin D and K influence the development of HCC.
• The active form of vitamin D and vitamin K exert an array of antitumor activities.
• Vitamin analogues have a potential role in HCC therapy.
Hepatocellular carcinoma (HCC) is a primary liver malignancy, and is now the six most common in between malignancies. Early diagnosis of HCC with prompt treatment increases the opportunity of patients to survive. With the advances in understanding the molecular biology of HCC, new therapeutic strategies to treat HCC have emerged. There is a growing consensus that vitamins are important for the control of various cancers. Biochemical evidence clearly indicates that HCC cells are responsive to the inhibitory effect of vitamin D, vitamin D analogues and vitamin K. In this review, we summarize the mechanisms used by vitamin D and K to influence the development of HCC and the latest development of vitamin analogues for potential HCC therapy.
(1,25(OH)2D3), 1,25-dihydroxycholecalciferol; (7-DHC), 7-dehydrocholesterol; (BCLC), Barcelona-Clınic Liver Cancer; (EPIC), The European Prospective Investigation into Cancer and Nutrition; (GGCX), gamma-glutamyl carboxylase; (HCC), hepatocellular carcinoma; (HDAC2), histone deacetylase 2; (HIF)-1, hypoxia inducible factor; (MMP-9), matrix metalloproteinase 9; (MAPK), mitogen-activated protein kinase; (PCT), proximal convoluted tubule; (PEGIFN), pegylated interferone; (PKC), protein kinase C; (RBV), ribavirin; (SNPs), single nucleotide polymorphisms; (SVR), sustained virological response; (TXNIP), thioredoxin-interacting protein; (TACE), trans-arterial chemo-embolisation; (TGF-β), transforming growth factor B; (VEGF), vascular endothelial growth factor; (DBP), vitamin D binding protein; (VDR), vitamin D receptor