Effect of Increasing Doses of Vitamin D on Bone Mineral Density and Serum N-terminal Telopeptide in Elderly Women: A Randomized Controlled Trial.
J Intern Med. 2018 Aug 23. doi: 10.1111/joim.12825. [Epub ahead of print]
Smith LM1, Gallagher JC2, Kaufmann M3, Jones G3.
1 Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE.
2 Bone Metabolism and Department Endocrinology, Creighton University School of Medicine, Omaha, NE.
3 Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
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There are few systematic studies of the effect of different doses of vitamin D3 on BMD. We conducted a randomized placebo-controlled trial in 163 Caucasian and 31 African American women with serum 25-hydroxyvitamin D (25OHD) ≤50 nmol/L (by Diasorin). They were randomly assigned to placebo, vitamin D3 400, 800, 1600, 2400, 3200, 4000, or 4800 IU/day; calcium supplements, average 600mg, were given to provide a total calcium intake of 1200 mg/d. The primary outcome was 12-month serum 25OHD level. This is an analysis of secondary outcome BMD to see if there is an association between percent change in BMD and dose of vitamin D3. Analysis methods include ANOVA and Pearson correlations. The mean percent increase (±SD) in BMD at 12 months for all women was small; total body, 0.62% (± 2.72), femoral neck 0.59% (±3.58) and spine 0.43% (±2.80). There was no difference in BMD response to vitamin D by dose or race. There was no significant change in BMD or serum N-terminal telopeptides in relation to 12-month serum total 25OHD, free 25OHD or change in serum 1,25(OH)2D. We found no evidence of a threshold change in BMD with increasing serum 25OHD or free 25OHD in this population. The increase in total body, spine and hip BMD in elderly women given vitamin D doses between 400 and 4800 IU daily and calcium supplementation is small, unrelated to dose or 12-month serum 25OHD, free 25OHD or 1,25(OH)2D.Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018Printer Friendly Follow this page for updates3801 visitors, last modified 24 Aug, 2018, This page is in the following categories (# of items in each category)