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Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019

The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K

Front. Cardiovasc. Med., 05 February 2019 | https://doi.org/10.3389/fcvm.2019.00006
Grzegorz B. Wasilewski1,2, Marc G. Vervloet3 and Leon J. Schurgers1*
1 Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
2 Nattopharma ASA, Hovik, Norway
3 Department of Nephrology and Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, Netherlands

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Interactions with P and Vit K
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Calcium supplements are broadly prescribed to treat osteoporosis either as monotherapy or together with vitamin D to enhance calcium absorption. It is still unclear whether calcium supplementation significantly contributes to the reduction of bone fragility and fracture risk. Data suggest that supplementing post-menopausal women with high doses of calcium has a detrimental impact on cardiovascular morbidity and mortality. Chronic kidney disease (CKD) patients are prone to vascular calcification in part due to impaired phosphate excretion. Calcium-based phosphate binders further increase risk of vascular calcification progression. In both bone and vascular tissue, vitamin K-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin K supplementation might protect from the potentially untoward effects of calcium supplementation. This review provides an update on current literature on calcium supplementation among post-menopausal women and CKD patients and discusses underlying molecular mechanisms of vascular calcification. We propose therapeutic strategies with vitamin K2 treatment to prevent or hold progression of vascular calcification as a consequence of excessive calcium intake.

Created by admin. Last Modification: Wednesday May 1, 2019 16:39:29 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
11824 Axis table 3 Interactions with P and Vit K.jpg admin 26 Apr, 2019 15:34 69.93 Kb 128
11823 Axis table 1 Ca types.jpg admin 26 Apr, 2019 15:31 80.37 Kb 122
11822 The Bone—Vasculature Axis.pdf PDF 2019 admin 26 Apr, 2019 15:31 989.76 Kb 34
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