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Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012

Combination of Micronutrients for Bone (COMB) Study: Bone Density after Micronutrient Intervention.

J Environ Public Health. 2012;2012:354151. Epub 2012 Jan 15.
Genuis SJ, Bouchard TP.
Faculty of Medicine, University of Alberta, Edmonton, AB, Canada T6K 4C1.

Along with other investigations, patients presenting to an environmental health clinic with various chronic conditions were assessed for bone health status. Individuals with compromised bone strength were educated about skeletal health issues and provided with therapeutic options for potential amelioration of their bone health. Patients who declined pharmacotherapy or who previously experienced failure of drug treatment were offered other options including supplemental micronutrients identified in the medical literature as sometimes having a positive impact on bone mineral density (BMD).

After 12 months of consecutive supplemental micronutrient therapy with a combination that included

  • vitamin D(3),
  • vitamin K(2),
  • strontium,
  • magnesium and
  • docosahexaenoic acid (DHA),

repeat bone densitometry was performed.
The results were analyzed in a group of compliant patients and demonstrate improved BMD in patients classified with normal, osteopenic and osteoporotic bone density.
According to the results, this combined micronutrient supplementation regimen appears to be
at least as effective as bisphosphonates or strontium ranelate in raising BMD levels in hip, spine, and femoral neck sites.

No fractures occurred in the group taking the micronutrient protocol.
This micronutrient regimen also appears to show efficacy in individuals where bisphosphonate therapy was previously unsuccessful in maintaining or raising BMD. Prospective clinical trials are required to confirm efficacy.

About 4% improvement in bone density

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2366

Those who do not take it (noncompliant) reduced bone density about 3%

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2366

Bone density increased by at least 3% in about half of the participants

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2366

PMID: 22291722
PDF is attached at the bottom of this page
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Table 1: Combination of micronutrients (COMB) Protocol for Bone Health.

COMB protocol for bone health

(1) Docosahexanoic acid or DHA (from Purified Fish Oil): 250 mg/day
(2) Vitamin D3: 2000 IU/day
(3) Vitamin K2 (non-synthetic MK7 form): 100 ug/day
(4) Strontium citrate: 680 mg/day (Comment: seems rather high)
(5) Elemental magnesium: 25 mg/day (Comment: seems rather low)
(6) Dietary sources of calcium recommended
(7) Daily impact exercising encouraged

Wonder why Boron and Silicon were not included

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See also VitaminDWiki

see wikipagehttp://www.vitamindwiki.com/tiki-index.php?page_id=1936

  • co-factors such as Magnesium, Vitamin K2, and Boron essential for Bone development has the following

4Bs = Bone, Bioavailability, Balance your Body

Have been unable to find a single study which considered including more than 2 of the co-factors

Must balance co-factors when increasing vitamin D

There is a lack of evidence of the interactions - the following are guesses based on incomplete information

Co-factor How Much Benefit BoneBioavailability Balance body Notes
Calcium <750mg Yes probablyYes Avoid getting too much
Magnesium 500mg Yes Yes Yes Very important, big range in bio-availability
Vitamin K2 Yes maybe ?
Vitamin A maybe ? need some, but too much is bad
Boron 5-10mg Yes 25% ?
Silica Yes no ?
Strontium Yes no ? rarely available in a co-factor pill
Zinc Yesmaybe?
  • Magnesium is probably the most important co-factor
    • Virtually everyone has become deficient in the past 50 years
    • What appears to be reaction to vitamin D is often due to a lack of Magnesium
    • Having more Magnesium increases vitamin D bio-availability
Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012        
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