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COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021


The effect of vitamin D supplementation on mortality and Intensive Care Unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression

Diabetes Metab Res Rev. 2021 Dec 29;e3517. doi: 10.1002/dmrr.3517
Nikolaos Tentolouris 1, Georgia Samakidou 1, Ioanna Eleftheriadou 1, Anastasios Tentolouris 1, Edward B Jude 2 Greece

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Aims: The aim of this systematic review and meta-analysis was to investigate the effect of vitamin D supplementation on mortality and admission to intensive care unit (ICU) of COVID-19 patients.

Methods: A systematic search of PubMed, Google Scholar, Embase, Web of Science and medRxiv with terms relative to vitamin D supplementation and COVID-19 was conducted on March, 26th , 2021. Comprehensive Meta-Analysis software was used for the quantitative assessment of data and random-effects model was applied. To investigate the association between the dose of vitamin D and the outcomes of interest, meta-regression analysis was performed.

Results: 2,078 patients from 9 studies with data on mortality were included (583 received vitamin D supplementation, while 1,495 did not). 61 (10.46%) individuals in the treated group died, compared to 386 (25.81%) in the non-treated group [odds ratio (OR): 0.597; 95% CI: 0.318-1.121; p=0.109]. 860 patients from 6 studies with data on ICU admission were included (369 received vitamin D supplementation, while 491 did not).

45 (12.19%) individuals in the treated group were admitted to ICU, compared to 129 (26.27%) in the non-treated group (OR: 0.326; 95%CI: 0.149-0.712; p=0.005). No significant linear relationship between vitamin D dose and log OR of mortality or log OR of ICU admission was observed.

Conclusion: This meta-analysis indicates a beneficial role of vitamin D supplementation on ICU admission, but not on mortality, of COVID-19 patients. Further research is urgently needed to understand the benefit of vitamin D in Covid-19.
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VitaminDWiki VIRUS category with ICU in title

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Items found: 24
Title Modified
Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023 12 Mar, 2024
COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis Jan 2023 22 Jan, 2023
COVID and Vitamin D: any amount of D, at any time, for any duration reduced ICU - meta-analysis Dec 2022 14 Dec, 2022
Elderly who had been in COVID ICU were 4X more likely to die if low vitamin D – Nov 2022 23 Jul, 2022
COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021 01 May, 2022
Hypothesis: 2 long-haul COVIDs: had mild symptoms and had needed ICU - April 2022 15 Apr, 2022
2.9 X less risk of COVID ICU if seniors had supplemented with Vitamin D (any amount) – April 2022 14 Apr, 2022
Vitamin D supplementation reduced risk of COVID-19 ICU by 2.8 X – review of 10 reviews Feb 2022 16 Feb, 2022
COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021 25 Dec, 2021
COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021 19 Oct, 2021
High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021 14 Oct, 2021
Vitamin D while in COVID-19 ICU does not help (no surprise) – July 2021 23 Jul, 2021
7X less likely to go to ICU if COVID-19 ward gave calcifediol (semi-activated Vitamin D) – July 2021 08 Jul, 2021
COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021 30 Jun, 2021
600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia) June 2021 22 Jun, 2021
COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT March 2021 18 Apr, 2021
6X less risk of COVID-19 ICU if Vitamin D and Vit B12 and Mg – Jan 2021 16 Apr, 2021
All COVID-19 in ICU had low vitamin D, no difference in outcome if low vs very low – Feb 2021 24 Feb, 2021
5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021 13 Feb, 2021
COVID-19 plus pneumonia in ICU with low vitamin D equaled Death - Dec 2020 04 Jan, 2021
Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020 04 Dec, 2020
Admission to COVID-19 ICU 1.7X more likely to have less than 20 ng of vitamin D – Sept 2020 17 Sep, 2020
ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020 06 Jul, 2020
Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020 30 Apr, 2020

VitaminDWiki - Meta-analysis of VIRUS

Attached files

ID Name Comment Uploaded Size Downloads
16829 ICU 3X full.jpg admin 30 Dec, 2021 464.41 Kb 378
16828 ICU 3X.jpg admin 30 Dec, 2021 84.51 Kb 424
16827 ICU 3X trimmed.jpg admin 30 Dec, 2021 96.86 Kb 330
16826 COVID ICU 3X vitamin D_compressed.pdf admin 30 Dec, 2021 494.58 Kb 252