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Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020

Vitamin D Insufficiency is Prevalent in Severe COVID-19 News-Medical.net

By Dr. Tomislav Meštrović, MD, Ph.D.Apr 29 2020
 Download the PDF from VitaminDWiki
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A new observational study from the United States indicates that vitamin D insufficiency may play a significant role in the progression of coronavirus disease (COVID-19). The research titled 'Vitamin D Insufficiency is Prevalent in Severe COVID-19' is available on the preprint server medRxiv.

A highly transmittable viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current pandemic of potentially fatal COVID-19 disease. The mechanisms underlying the contrasting outcomes of this disease are still unknown.

Although 80-85% of patients present with self-limiting disease or do not present with any symptoms, the remaining need significant hospital resources and may potentially collapse the healthcare system, as evidenced by the situation in Italy.

The US experience sheds some light on different COVID-19 scenarios and outcomes. Even though they represent only 32% of the US population, African Americans account for 70% of COVID-19 deaths; on the other hand, homeless individuals in Boston shelter were 100% asymptomatic.

Risk factors for COVID-19 mortality recognized thus far include male sex, obesity, hypertension, advanced age, and COVID-19 associated coagulopathy. However, vitamin D insufficiency may soon be added to the list of risk factors, according to the researchers from the Louisiana State University Health Sciences Center New Orleans, Tulane School of Medicine, and Texas A&M College of Medicine.

The significance of vitamin D
Vitamin D is a molecule that displays an essential physiological impact and has a pivotal role in modulating both innate and adaptive immune responses. Since the average human diet is not rich in vitamin D of either plant or animal origin, humans depend on endogenous production after ultraviolet B (UVB) exposure.

Furthermore, vitamin D-dependent antimicrobial pathways are known to respond to double-stranded RNA, which is readily produced during SARS-CoV-2 viral replication. These pathways subsequently up-regulate the removal of damaged cells (autophagy), as well as various antimicrobial and antiviral peptides.

Consequently, vitamin D insufficiency hampers the host's ability to activate the aforementioned defensive pathways but also been influences lymphocyte and macrophage migration. Since such deranged immune response predisposes the host to viral respiratory infections, is the same valid for COVID-19?

To better define the link between the vitamin D insufficiency and COVID-19, the US research group (headed by Dr. Frank H. Lau from the Department of Surgery of the Louisiana State University Health Sciences Center New Orleans) aimed to determine the prevalence of vitamin D insufficiency among our COVID-19 intensive care unit (ICU) patients.

The study was performed at a tertiary care academic medical center by retrospectively reviewing medical records of COVID-19 patients and analyzing serum 25-hydroxycholecalciferol (25OHD) levels, which represent the major circulating form of vitamin D. The insufficiency was defined as 25OHD serum levels lower than 30 nanograms per milliliter.

The baseline prevalence of vitamin D insufficiency amongst ICU patients was 30-40%; furthermore, 84.6% of ICU patients had the insufficiency (compared to 57.1% of floor patients). The most striking finding was that 100% of ICU patients younger than 75 had vitamin D insufficiency.

"Given these data, we hypothesize that vitamin D insufficiency enhances COVID-19 severity via

  • 1) its prothrombotic effects and
  • 2) its derangement of the immune response",

say study authors.


COVID-19 treated by Vitamin D - studies, reports, videos


Vitamin D is being used to fight COVID-19

Intervention Clinical Trials
Intervention Trial Summary June 29
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Observational Clinical Trials

Vitamin D Dosing Recommendations for COVID-19

  • Portion of image from June 5 video (below)
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  • Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic Metabolism, June 2, FREE PDF, peer-reviewed publication
    • "Preventive doses of vitamin D3 of 10,000 IU/day for 4 weeks followed by 5000 IU/day to reach a target 25(OH)D level of 100–150 nmol/L [24], and treatment doses >6000 IU/day in deficient individuals to reach a similar level and reduce disease progression [48], are suggested. ""
    • Comment: Strange that the treatment dose is less than the prevention dose. Note treatment dose will take > 3 months to help
      • Perhaps they meant the treatment dose to be 60,000 IU, not 6,000 IU
  • Perspective: improving vitamin D status in the management of COVID-19 May 22 free PDF
    • If low: 50,000 IU twice a week at the diagnosis (100,000 IU total)., then 50,000 IU taken once a week for the 2nd and 3rd weeks.
      • Note: VitaminDWiki believes that this dosing is not large enough for prevention, much less treatment
  • COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020
  • for people who have not been taking any vitamin D BusinessWorld May 22 - by Dr Renu Mahtani in videos below
    • Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
    • or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
    • Thus 480,000 IU total, No Vitamin D testing needed

Some people wanted improved immune systems, so took more vitamin D

COVID-19 associated with Low Vitamin D

Vitamin D levels are lower in those who test positive for COVID-19 -[doi:10.3390/nu12051359| Nutrients] May 09

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  • [https://articles.mercola.com/sites/articles/archive/2020/05/08/vitamin-d-level-correlated-to-covid19-outcomes.aspx?cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20200508Z1&et_cid=DM527863&et_rid=867359477 |Vitamin D Level Is Directly Correlated to COVID-19 Outcome] Mercola May 8
    • Overview of many studies and video by Ivor Cummins
  • [https://www.sciencedaily.com/releases/2020/05/200507131012.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fvitamin_d+%28Vitamin+D+News+--+ScienceDaily%29 |Vitamin D linked to low virus death rate in 20 countries in Europe] Science Daily May 7
  • [https://doi.org/10.1101/2020.05.01.20087965 |Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes] May 6 preprint
    • Excellent extensive use of Causal Influence AI to discover associations.
    • I have suspected that Causal Influence could be much better, far lower cost, and faster than the use of RCTs
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3586555|Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 deaths] preprint May 7
    • "permanent unit increase in UVI is associated with a 2.2 % decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01]
    • as well as a 1.9 % decline in the daily growth rates of CFR [p < 0.05]
    • 64 countries, 78 days, 6 UVI models
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3593258#.XrE0oF1wSjU.twitter |Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report] May 5
    • 176 seniors in S. Asia - published in India
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  • Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020
  • COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
  • COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 Philippines
    • The raw data has strange gaps in the vitamin D levels
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  • Research Suggests a Link Between Vitamin D Deficiency and COVID-19 Deaths May 5
  • Indonesia preprint 13X if vitamin D insufficient,19X for patients who are vitamin D deficient.
    • VitaminDWiki has requested but has not yet access to the raw data
  • COVID-19 infections associated with very low vitamin D – Turin Italy – March 2020

Speculation

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Higher levels of vitamin D result in fewer COVID-19 problems

VIDEOS and PODCASTS


Search Google Scholar for "COVID-19" "Vitamin D"
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13779 April 29 T3.jpg admin 30 Apr, 2020 00:01 78.21 Kb 545
13778 April 29.jpg admin 30 Apr, 2020 00:00 63.82 Kb 563
13777 Vitamin D Insufficiency is Prevalent in Severe COVID-19.pdf PDF 2020 admin 30 Apr, 2020 00:00 274.84 Kb 133
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