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2.9 X less risk of COVID ICU if seniors had supplemented with Vitamin D (any amount) – April 2022

Vitamin D and COVID-19 Severity in Hospitalized Older Patients -Potential Benefit of Prehospital Vitamin D Supplementation

François Parant 1, Justin Bouloy 2,* , Julie Haesebaert 3,4 , Lamia Bendim’red 5, Karine Goldet 5,
Philippe Vanhems 6,7, Laetitia Henaff 6,7, Thomas Gilbert 2,4 , Charlotte Cuerq 1, Emilie Blond 1, Muriel Bost 1
and Marc Bonnefoy 2

ICU Average for any dosing interval: 1,000 IU daily up to 100,000 IU very 3 months

Studies involving the associations between vitamin D supplementation taken before the onset of COVID-19 infection and the clinical outcomes are still scarce and this issue remains controversial. This study aimed to assess the relationships between vitamin D (VitD) status and supplementation and coronavirus disease 2019 (COVID-19) severity in older adults (average age of 78 years) hospitalized for COVID-19. We conducted an observational retrospective cohort study with 228 older hospitalized patients during the first wave of the COVID-19 pandemic. The outcomes were in-hospital mortality secondary to COVID-19 or critically severe COVID-19. A logistic regression analysis was conducted to test whether pre-hospital VitD supplementation was independently associated with severity. In this study, 46% of patients developed a severe form and the overall in-hospital mortality was 15%.

Sixty-six (29%) patients received a VitD supplement during the 3 months preceding the infection onset. Additionally, a VitD supplement was associated with fewer severe COVID-19 forms (OR = 0.426, p = 0.0135) and intensive care unit (ICU) admissions (OR = 0.341, p = 0.0076). As expected, age > 70 years, male gender and BMI ≥ 35 kg/m2 were independent risk factors for severe forms of COVID-19. No relationship between serum 25(OH)D levels and the severity of the COVID-19 was identified. VitD supplementation taken during the 3 months preceding the infection onset may have a protective effect on the development of severe COVID-19 forms in older adults. Randomized controlled trials and large-scale cohort studies are necessary to strengthen this observation.
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Study Observations by VitaminDWiki

  • Study is based on data from early 2020.
    • Wonder why they took so long to publish it?
  • Study only reports on those seniors who went to the hospital.
  • Suspect that many seniors who supplemented never went to the hospital.
  • Study did not compute ICU risk vs dose size nor dose interval
    • which ranged from as much as 80,000 IU every 3 months to as little as 1,000 IU daily.
  • Vitamin D levels measured in the hospital were not statistically significantly related to any COVID variable
  • Vitamin D may not have been the reason for the benefit. Might have just tried many ways to improve health.
    • Other possible reasons include: take Magnesium, take Omega-3, take Vitamin K2, eat better, exercise more

VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

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VitaminDWiki – Only a single supplement taken before infection decreased COVID severity (vitamin D) – Feb 2022

Created by admin. Last Modification: Saturday April 23, 2022 18:17:37 GMT-0000 by admin. (Version 11)

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17411 COVID with pre-hosptial supplementation.pdf admin 14 Apr, 2022 621.45 Kb 132